Overview
Semax is a synthetic peptide derived from adrenocorticotropic hormone (ACTH) fragment 4-10, developed at the Institute of Molecular Genetics in Moscow. It is approved in Russia and Ukraine as a prescription nootropic for cognitive enhancement, stroke recovery, and neuroprotection. It enhances memory, attention, and learning without stimulant-like side effects.
Mechanism of action
Semax increases BDNF and NGF (nerve growth factor) expression in the hippocampus and cortex, promoting neuronal survival and plasticity. It modulates the dopaminergic and serotonergic systems, enhances the expression of TrkB receptors, and activates the MAPK/ERK signaling pathway involved in long-term memory formation. It also has antioxidant properties protecting neurons from oxidative stress.
Dosing protocols
| Purpose | Route | Dosage | Frequency | Notes |
|---|---|---|---|---|
| cognitive enhancement | nasal | 200–600 mcg | 2-3x daily | Nasal spray is standard. Start at 200mcg. Available in 0.1% and 1% solutions in Russia. Cycles of 10-20 days. |
Dosing information is for educational purposes only. Consult a qualified healthcare professional before using any peptide.
Research summary
Extensive Russian clinical research demonstrates cognitive enhancement in healthy subjects and significant neuroprotective effects in stroke patients (reduced infarct volume, improved recovery). A key study showed 1.5-2x increases in BDNF after 7 days of administration. Approved in Russia for: acute ischemic stroke, cognitive disorders, peptic ulcer, and optic nerve disease. Well-tolerated with minimal side effects. No reported addiction or tolerance.
Side effects
Side effects vary by individual. This is not an exhaustive list. Report unusual symptoms to a healthcare professional.
Common stacks
Peptides commonly paired with Semax for synergistic effects.
Legal status
Approved as a prescription drug in Russia and Ukraine. Not FDA-approved. Available as a research peptide in the US. Not scheduled.
Where to get it
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