Overview
Heptapeptide-7 is a synthetic seven-amino-acid peptide fragment derived from HB-107, a wound-healing peptide with EGF-like (epidermal growth factor) activity. It is used in cosmetic formulations targeting dermal regeneration, stretch mark improvement, and age-related skin thinning. The peptide stimulates both keratinocyte and fibroblast activity, making it a dual-action skin-signaling compound.
Mechanism of action
Heptapeptide-7 exerts EGF-mimetic activity by binding to signaling pathways that regulate keratinocyte proliferation and migration. Microarray analysis of HP-7-treated dermal keratinocytes shows upregulation of cell division, growth factor expression, and extracellular matrix genes. The peptide also stimulates fibroblast proliferation and collagen synthesis, and enhances cell-to-cell communication pathways involved in wound healing and dermal regeneration. These combined effects support skin thickness, elasticity, and repair following environmental damage or stretch-related stress.
Dosing protocols
| Purpose | Route | Dosage | Frequency | Notes |
|---|---|---|---|---|
| dermal regeneration / stretch mark reduction | topical | 1–5 % | once or twice daily | Applied to areas of concern such as abdomen, thighs, or periorbital skin. Consistent daily use recommended. |
Dosing information is for educational purposes only. Consult a qualified healthcare professional before using any peptide.
Research summary
Ex vivo studies demonstrate that Heptapeptide-7 promotes keratinocyte proliferation and migration and enhances fibroblast collagen production. Microarray data show upregulation of ECM and growth factor gene networks. Clinical and in vivo studies are limited; most evidence is from in vitro cosmetic ingredient research. Marketed primarily for stretch mark prevention and menopausal skin improvement. No published RCTs as of 2026.
Side effects
Side effects vary by individual. This is not an exhaustive list. Report unusual symptoms to a healthcare professional.
Common stacks
Peptides commonly paired with Heptapeptide-7 for synergistic effects.
Legal status
OTC cosmetic ingredient. Used in topical serums and body creams. No regulatory restrictions in EU, US, or major markets.
Where to get it
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