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Desmopressin dose calculator

Reported study range for central diabetes insipidus (oral): 0.050.4 mg two to three times daily (oral). Convert it below, including draw volume and syringe units.

Convert your Desmopressin dose
Vial
Result
Converted amount0.05 mg
Dose mass50 mcg
Concentration2,500 mcg/mL
Draw volume0.02 mL
U-100 syringe2 units
Reported study ranges
PurposeRouteReported rangeFrequency
central diabetes insipidus (oral)oral0.050.4 mgtwo to three times daily
primary nocturnal enuresis (oral tablet)oral0.20.6 mgonce at bedtime
hemophilia A / von Willebrand disease (IV/SC)subcutaneous0.30.3 mcg/kgsingle dose pre-procedure
hemophilia A / von Willebrand disease (IV)intravenous0.30.3 mcg/kgsingle dose pre-procedure

Ranges are reported from the literature for research context only. They are not a protocol and not a recommendation.

Concentration by vial and diluent
Vial1 mL diluent2 mL diluent3 mL diluent
2 mg2,000 mcg/mL1,000 mcg/mL667 mcg/mL
5 mg5,000 mcg/mL2,500 mcg/mL1,667 mcg/mL
10 mg10,000 mcg/mL5,000 mcg/mL3,333 mcg/mL

Concentration is vial mass divided by diluent volume. Reconstitution volume changes what you draw, never the dose itself.

What to draw for 50 mcg
VialDiluentDraw volumeU-100 unitsDoses per vial
2 mg1 mL0.025 mL2.5 units40
2 mg2 mL0.05 mL5 units40
2 mg3 mL0.075 mL7.5 units40
5 mg1 mL0.01 mL1 units100
5 mg2 mL0.02 mL2 units100
5 mg3 mL0.03 mL3 units100
10 mg1 mL0.005 mL0.5 units200
10 mg2 mL0.01 mL1 units200
10 mg3 mL0.015 mL1.5 units200

Calculated for the low end of the reported central diabetes insipidus (oral) range. Change the dose in the calculator above for any other amount.

Desmopressin at a glance
~1.5–2.5 hours (nasal/IV); ~2–3 hours (oral)
Half-life
1,069.22 Da
Molecular weight
oral, nasal, subcutaneous, intravenous
Routes
prescription
Legal status
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