Overview
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural peptide epithalamin, which is produced by the pineal gland. It was discovered by Russian gerontologist Professor Vladimir Khavinson, who spent over 35 years researching peptide bioregulators. Epithalon is the most studied peptide in the field of aging, specifically for its ability to activate telomerase and extend telomere length.
Mechanism of action
Epithalon activates telomerase, the enzyme that adds telomeric repeats (TTAGGG) to the ends of chromosomes, counteracting the telomere shortening that occurs with each cell division and is associated with aging. It also stimulates melatonin production by the pineal gland, regulates the neuroendocrine system, and normalizes anterior pituitary function. Khavinson's research suggests it acts as a peptide bioregulator at the gene expression level.
Dosing protocols
| Purpose | Route | Dosage | Frequency | Notes |
|---|---|---|---|---|
| anti-aging / telomerase activation | subcutaneous | 5–10 mg | daily | Typical protocol: 5-10mg daily for 10-20 days, repeated every 4-6 months. Based on Khavinson's clinical protocols. |
Dosing information is for educational purposes only. Consult a qualified healthcare professional before using any peptide.
Research summary
Khavinson's research spans 35+ years and over 100 publications. Key findings: telomerase activation in human somatic cells in vitro, increased telomere length, extended lifespan in animal models (mice: 13.3% increase). A 15-year human observational study on elderly patients showed reduced mortality (1.6-1.8x) in the epithalamin group. Pineal gland function restoration and melatonin normalization demonstrated in aged patients. Limitations: most human data is from Russian studies with limited Western peer review.
Side effects
Side effects vary by individual. This is not an exhaustive list. Report unusual symptoms to a healthcare professional.
Common stacks
Peptides commonly paired with Epithalon for synergistic effects.
Legal status
Not FDA-approved. Available as a research peptide. Epithalamin (the natural extract) is approved in Russia as a pharmaceutical. The synthetic version (Epithalon) is sold as a research chemical internationally.
Where to get it
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