Overview
Deltorphin is a family of heptapeptides isolated from the skin of South American Phyllomedusa frogs. These opioid peptides show exceptional selectivity for delta-opioid receptors, with affinity several orders of magnitude greater than for mu-opioid receptors, making them invaluable research tools for studying pain modulation and opioid receptor pharmacology.
Mechanism of action
Deltorphins bind with high selectivity to delta-opioid receptors (DOR), acting as potent agonists. Activation of DOR inhibits adenylyl cyclase via Gi/Go proteins, reduces neuronal excitability, and modulates neurotransmitter release. Unlike mu-opioid receptor agonists, delta-selective compounds may produce analgesia with reduced respiratory depression, tolerance, and physical dependence, making them subjects of interest for analgesic drug development.
Dosing protocols
| Purpose | Route | Dosage | Frequency | Notes |
|---|---|---|---|---|
| receptor binding research | intravenous | 1–10 mcg/kg | single dose per experiment |
Dosing information is for educational purposes only. Consult a qualified healthcare professional before using any peptide.
Research summary
Preclinical studies confirm Deltorphin's role as a delta-opioid receptor agonist with nanomolar affinity. Research has explored its analgesic, cardioprotective, and neuroprotective properties in rodent models. Deltorphin II has been used extensively to characterize DOR pharmacology. No human clinical trials have been conducted due to its research-only status.
Side effects
Side effects vary by individual. This is not an exhaustive list. Report unusual symptoms to a healthcare professional.
Legal status
Deltorphins are not approved for human use and are available for research purposes only. They are not scheduled substances in most jurisdictions but require appropriate laboratory handling protocols.
Where to get it
Verified directory — coming soon
PeptaHub is building a verified supplier directory with third-party testing data, compliance status, and reader ratings.