{
  "dataset": "PeptaHub Peptide Research Volume Dataset",
  "description": "Annual PubMed publication counts for 156 peptide compounds, 2000-2026, derived from NCBI E-utilities esearch title/abstract queries.",
  "version": "2026-07-23",
  "pulled_at": "2026-07-23",
  "source": "NCBI PubMed E-utilities (esearch.fcgi)",
  "source_url": "https://www.ncbi.nlm.nih.gov/books/NBK25501/",
  "license": "CC BY 4.0",
  "license_url": "https://creativecommons.org/licenses/by/4.0/",
  "attribution": "PeptaHub (peptahub.com)",
  "canonical_url": "https://peptahub.com/research-trends",
  "citation": "PeptaHub. \"Peptide Research Volume Dataset (2000-2026).\" peptahub.com, 2026-07-23. https://peptahub.com/research-trends. Licensed CC BY 4.0.",
  "years": [
    2000,
    2001,
    2002,
    2003,
    2004,
    2005,
    2006,
    2007,
    2008,
    2009,
    2010,
    2011,
    2012,
    2013,
    2014,
    2015,
    2016,
    2017,
    2018,
    2019,
    2020,
    2021,
    2022,
    2023,
    2024,
    2025,
    2026
  ],
  "methodology": [
    {
      "heading": "Query shape",
      "body": "For each compound the query is an OR of quoted terms restricted to the title/abstract field, for example: \"BPC-157\"[tiab] OR \"Bepecin\"[tiab]. Terms are the canonical compound name plus the compound-specific synonyms carried on that peptide's profile. The exact query used for every compound is included in the download."
    },
    {
      "heading": "Year binning",
      "body": "Yearly counts use publication date (datetype=pdat) with mindate=YYYY/01/01 and maxdate=YYYY/12/31. The unbounded total can exceed the sum of the yearly counts because it includes records published before 2000."
    },
    {
      "heading": "Synonym handling",
      "body": "PubMed term matching is case-insensitive, so MOTS-c and MOTS-C resolve to one term and are never double counted. Synonyms that name a compound class, a preparation, or a bare acronym under five characters are excluded, because a term like SP or Type I Collagen would pull in thousands of unrelated records. Every excluded term and the reason for excluding it ships in the download."
    },
    {
      "heading": "Diagnostics",
      "body": "Each record also carries a name-only count, so you can see how much the synonym list contributes, and an applied-context count that intersects the primary query with administration and therapy vocabulary. Both are reported for transparency; neither adjusts the headline numbers."
    }
  ],
  "limitations": [
    "Publication volume measures research attention, not efficacy, safety, or evidence quality. A compound with more papers is not a better or safer compound.",
    "Title/abstract matching misses records that carry a compound only as a MeSH term, and catches records that mention a compound in passing.",
    "PubMed indexing lags publication. The most recent year is always undercounted and should never be read as a decline.",
    "Endogenous and structural molecules such as oxytocin, glutathione, and collagen carry decades of basic-biology literature that is not research into administering them. Those rows are marked context-dependent.",
    "Some compounds share a name or acronym with unrelated biology. Those rows are marked low reliability and their counts should be treated as upper bounds.",
    "Counts are a snapshot. PubMed is continuously revised, so the same query run later returns slightly different numbers."
  ],
  "record_count": 156,
  "records": [
    {
      "slug": "glutathione",
      "name": "Glutathione",
      "category": "longevity",
      "url": "https://peptahub.com/peptides/glutathione",
      "query": "\"Glutathione\"[tiab] OR \"L-Glutathione\"[tiab] OR \"Reduced Glutathione\"[tiab]",
      "query_terms": [
        "Glutathione",
        "L-Glutathione",
        "Reduced Glutathione"
      ],
      "excluded_terms": [
        {
          "term": "GSH",
          "reason": "too-short"
        },
        {
          "term": "Gly-Cys-Glu",
          "reason": "residue-sequence"
        }
      ],
      "total_all_years": 177616,
      "total_in_window": 162435,
      "name_only_total": 177616,
      "synonym_contribution": 0,
      "applied_context_total": 73663,
      "applied_context_share": 0.415,
      "first_year_in_window": 2000,
      "publications_2016_2020": 35512,
      "publications_2021_2025": 45751,
      "growth_ratio_5y": 1.29,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 2986,
        "2001": 3026,
        "2002": 3130,
        "2003": 3427,
        "2004": 3603,
        "2005": 4235,
        "2006": 4274,
        "2007": 4478,
        "2008": 4538,
        "2009": 4773,
        "2010": 5275,
        "2011": 5534,
        "2012": 5992,
        "2013": 6357,
        "2014": 6435,
        "2015": 6480,
        "2016": 6385,
        "2017": 6542,
        "2018": 6978,
        "2019": 7343,
        "2020": 8264,
        "2021": 8617,
        "2022": 9016,
        "2023": 8528,
        "2024": 9181,
        "2025": 10409,
        "2026": 6629
      }
    },
    {
      "slug": "angiotensin-ii",
      "name": "Angiotensin II",
      "category": "other",
      "url": "https://peptahub.com/peptides/angiotensin-ii",
      "query": "\"Angiotensin II\"[tiab] OR \"Ang II\"[tiab] OR \"Giapreza\"[tiab] OR \"Angiotensin-II human\"[tiab]",
      "query_terms": [
        "Angiotensin II",
        "Ang II",
        "Giapreza",
        "Angiotensin-II human"
      ],
      "excluded_terms": [],
      "total_all_years": 61490,
      "total_in_window": 46077,
      "name_only_total": 58011,
      "synonym_contribution": 0.057,
      "applied_context_total": 27212,
      "applied_context_share": 0.443,
      "first_year_in_window": 2000,
      "publications_2016_2020": 8620,
      "publications_2021_2025": 8369,
      "growth_ratio_5y": 0.97,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 1463,
        "2001": 1574,
        "2002": 1620,
        "2003": 1650,
        "2004": 1683,
        "2005": 1808,
        "2006": 1688,
        "2007": 1739,
        "2008": 1842,
        "2009": 1706,
        "2010": 1864,
        "2011": 1813,
        "2012": 1981,
        "2013": 1966,
        "2014": 1884,
        "2015": 1873,
        "2016": 1642,
        "2017": 1683,
        "2018": 1607,
        "2019": 1625,
        "2020": 2063,
        "2021": 2055,
        "2022": 1740,
        "2023": 1533,
        "2024": 1480,
        "2025": 1561,
        "2026": 934
      }
    },
    {
      "slug": "glucagon",
      "name": "Glucagon",
      "category": "other",
      "url": "https://peptahub.com/peptides/glucagon",
      "query": "\"Glucagon\"[tiab] OR \"GlucaGen\"[tiab] OR \"glucagon rDNA origin\"[tiab] OR \"glucagon HCl\"[tiab]",
      "query_terms": [
        "Glucagon",
        "GlucaGen",
        "glucagon rDNA origin",
        "glucagon HCl"
      ],
      "excluded_terms": [],
      "total_all_years": 55232,
      "total_in_window": 41290,
      "name_only_total": 55223,
      "synonym_contribution": 0,
      "applied_context_total": 26415,
      "applied_context_share": 0.478,
      "first_year_in_window": 2000,
      "publications_2016_2020": 9186,
      "publications_2021_2025": 14438,
      "growth_ratio_5y": 1.57,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 499,
        "2001": 485,
        "2002": 547,
        "2003": 518,
        "2004": 626,
        "2005": 600,
        "2006": 637,
        "2007": 698,
        "2008": 786,
        "2009": 887,
        "2010": 935,
        "2011": 1089,
        "2012": 1261,
        "2013": 1400,
        "2014": 1592,
        "2015": 1635,
        "2016": 1686,
        "2017": 1721,
        "2018": 1855,
        "2019": 1896,
        "2020": 2028,
        "2021": 2233,
        "2022": 2220,
        "2023": 2300,
        "2024": 3200,
        "2025": 4485,
        "2026": 3471
      }
    },
    {
      "slug": "vasopressin",
      "name": "Vasopressin",
      "category": "other",
      "url": "https://peptahub.com/peptides/vasopressin",
      "query": "\"Vasopressin\"[tiab] OR \"Vasostrict\"[tiab] OR \"arginine vasopressin\"[tiab]",
      "query_terms": [
        "Vasopressin",
        "Vasostrict",
        "arginine vasopressin"
      ],
      "excluded_terms": [
        {
          "term": "ADH",
          "reason": "too-short"
        },
        {
          "term": "AVP",
          "reason": "too-short"
        },
        {
          "term": "antidiuretic hormone",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 37906,
      "total_in_window": 18334,
      "name_only_total": 37906,
      "synonym_contribution": 0,
      "applied_context_total": 13370,
      "applied_context_share": 0.353,
      "first_year_in_window": 2000,
      "publications_2016_2020": 3425,
      "publications_2021_2025": 3247,
      "growth_ratio_5y": 0.95,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 667,
        "2001": 637,
        "2002": 643,
        "2003": 655,
        "2004": 723,
        "2005": 711,
        "2006": 759,
        "2007": 691,
        "2008": 800,
        "2009": 678,
        "2010": 713,
        "2011": 677,
        "2012": 694,
        "2013": 671,
        "2014": 726,
        "2015": 727,
        "2016": 726,
        "2017": 681,
        "2018": 648,
        "2019": 701,
        "2020": 669,
        "2021": 693,
        "2022": 635,
        "2023": 599,
        "2024": 594,
        "2025": 726,
        "2026": 490
      }
    },
    {
      "slug": "somatostatin",
      "name": "Somatostatin",
      "category": "other",
      "url": "https://peptahub.com/peptides/somatostatin",
      "query": "\"Somatostatin\"[tiab] OR \"Somatotropin Release-Inhibiting Factor\"[tiab] OR \"SST-14\"[tiab] OR \"SST-28\"[tiab]",
      "query_terms": [
        "Somatostatin",
        "Somatotropin Release-Inhibiting Factor",
        "SST-14",
        "SST-28"
      ],
      "excluded_terms": [
        {
          "term": "SRIF",
          "reason": "too-short"
        },
        {
          "term": "Growth Hormone-Inhibiting Hormone",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 35126,
      "total_in_window": 20718,
      "name_only_total": 35098,
      "synonym_contribution": 0.001,
      "applied_context_total": 15352,
      "applied_context_share": 0.437,
      "first_year_in_window": 2000,
      "publications_2016_2020": 4210,
      "publications_2021_2025": 4733,
      "growth_ratio_5y": 1.12,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 673,
        "2001": 687,
        "2002": 639,
        "2003": 650,
        "2004": 733,
        "2005": 670,
        "2006": 626,
        "2007": 643,
        "2008": 714,
        "2009": 626,
        "2010": 709,
        "2011": 674,
        "2012": 769,
        "2013": 740,
        "2014": 771,
        "2015": 768,
        "2016": 816,
        "2017": 783,
        "2018": 807,
        "2019": 890,
        "2020": 914,
        "2021": 984,
        "2022": 930,
        "2023": 848,
        "2024": 921,
        "2025": 1050,
        "2026": 683
      }
    },
    {
      "slug": "calcitonin",
      "name": "Calcitonin",
      "category": "other",
      "url": "https://peptahub.com/peptides/calcitonin",
      "query": "\"Calcitonin\"[tiab] OR \"Miacalcin\"[tiab] OR \"Fortical\"[tiab] OR \"salmon calcitonin\"[tiab] OR \"calcitonin salmon\"[tiab]",
      "query_terms": [
        "Calcitonin",
        "Miacalcin",
        "Fortical",
        "salmon calcitonin",
        "calcitonin salmon"
      ],
      "excluded_terms": [],
      "total_all_years": 29697,
      "total_in_window": 18399,
      "name_only_total": 29694,
      "synonym_contribution": 0,
      "applied_context_total": 11927,
      "applied_context_share": 0.402,
      "first_year_in_window": 2000,
      "publications_2016_2020": 3406,
      "publications_2021_2025": 4471,
      "growth_ratio_5y": 1.31,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 604,
        "2001": 655,
        "2002": 592,
        "2003": 609,
        "2004": 637,
        "2005": 626,
        "2006": 650,
        "2007": 585,
        "2008": 577,
        "2009": 565,
        "2010": 623,
        "2011": 624,
        "2012": 628,
        "2013": 668,
        "2014": 592,
        "2015": 610,
        "2016": 585,
        "2017": 645,
        "2018": 647,
        "2019": 711,
        "2020": 818,
        "2021": 887,
        "2022": 818,
        "2023": 817,
        "2024": 935,
        "2025": 1014,
        "2026": 677
      }
    },
    {
      "slug": "oxytocin",
      "name": "Oxytocin",
      "category": "sexual-health",
      "url": "https://peptahub.com/peptides/oxytocin",
      "query": "\"Oxytocin\"[tiab] OR \"Pitocin\"[tiab] OR \"Syntocinon\"[tiab]",
      "query_terms": [
        "Oxytocin",
        "Pitocin",
        "Syntocinon"
      ],
      "excluded_terms": [
        {
          "term": "Love Hormone",
          "reason": "class-descriptor"
        },
        {
          "term": "Bonding Hormone",
          "reason": "class-descriptor"
        },
        {
          "term": "OXT",
          "reason": "too-short"
        }
      ],
      "total_all_years": 29436,
      "total_in_window": 20272,
      "name_only_total": 29170,
      "synonym_contribution": 0.009,
      "applied_context_total": 10861,
      "applied_context_share": 0.369,
      "first_year_in_window": 2000,
      "publications_2016_2020": 5226,
      "publications_2021_2025": 5402,
      "growth_ratio_5y": 1.03,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 421,
        "2001": 439,
        "2002": 391,
        "2003": 407,
        "2004": 422,
        "2005": 423,
        "2006": 425,
        "2007": 445,
        "2008": 490,
        "2009": 505,
        "2010": 587,
        "2011": 595,
        "2012": 703,
        "2013": 807,
        "2014": 888,
        "2015": 944,
        "2016": 969,
        "2017": 1027,
        "2018": 1067,
        "2019": 1062,
        "2020": 1101,
        "2021": 1146,
        "2022": 1086,
        "2023": 1006,
        "2024": 1027,
        "2025": 1137,
        "2026": 752
      }
    },
    {
      "slug": "vip",
      "name": "VIP",
      "category": "immune",
      "url": "https://peptahub.com/peptides/vip",
      "query": "\"VIP\"[tiab] OR \"Vasoactive Intestinal Peptide\"[tiab] OR \"Vasoactive Intestinal Polypeptide\"[tiab] OR \"Aviptadil\"[tiab] OR \"PHM-27\"[tiab]",
      "query_terms": [
        "VIP",
        "Vasoactive Intestinal Peptide",
        "Vasoactive Intestinal Polypeptide",
        "Aviptadil",
        "PHM-27"
      ],
      "excluded_terms": [],
      "total_all_years": 29025,
      "total_in_window": 21288,
      "name_only_total": 24915,
      "synonym_contribution": 0.142,
      "applied_context_total": 9693,
      "applied_context_share": 0.334,
      "first_year_in_window": 2000,
      "publications_2016_2020": 4403,
      "publications_2021_2025": 8944,
      "growth_ratio_5y": 2.03,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound. The query also leans on a short acronym, so treat the count as an upper bound.",
      "by_year": {
        "2000": 428,
        "2001": 368,
        "2002": 383,
        "2003": 366,
        "2004": 366,
        "2005": 291,
        "2006": 382,
        "2007": 366,
        "2008": 362,
        "2009": 324,
        "2010": 368,
        "2011": 389,
        "2012": 426,
        "2013": 533,
        "2014": 563,
        "2015": 571,
        "2016": 598,
        "2017": 624,
        "2018": 792,
        "2019": 994,
        "2020": 1395,
        "2021": 1497,
        "2022": 1736,
        "2023": 1649,
        "2024": 1849,
        "2025": 2213,
        "2026": 1455
      }
    },
    {
      "slug": "substance-p",
      "name": "Substance P",
      "category": "other",
      "url": "https://peptahub.com/peptides/substance-p",
      "query": "\"Substance P\"[tiab]",
      "query_terms": [
        "Substance P"
      ],
      "excluded_terms": [
        {
          "term": "SP",
          "reason": "too-short"
        },
        {
          "term": "Neurokinin P",
          "reason": "class-descriptor"
        },
        {
          "term": "substance P undecapeptide",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 24280,
      "total_in_window": 11617,
      "name_only_total": 24280,
      "synonym_contribution": 0,
      "applied_context_total": 6903,
      "applied_context_share": 0.284,
      "first_year_in_window": 2000,
      "publications_2016_2020": 1919,
      "publications_2021_2025": 1780,
      "growth_ratio_5y": 0.93,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 604,
        "2001": 593,
        "2002": 543,
        "2003": 536,
        "2004": 503,
        "2005": 501,
        "2006": 504,
        "2007": 516,
        "2008": 505,
        "2009": 458,
        "2010": 457,
        "2011": 395,
        "2012": 385,
        "2013": 394,
        "2014": 424,
        "2015": 359,
        "2016": 331,
        "2017": 375,
        "2018": 398,
        "2019": 403,
        "2020": 412,
        "2021": 363,
        "2022": 341,
        "2023": 378,
        "2024": 350,
        "2025": 348,
        "2026": 241
      }
    },
    {
      "slug": "atrial-natriuretic-peptide",
      "name": "Atrial Natriuretic Peptide",
      "category": "other",
      "url": "https://peptahub.com/peptides/atrial-natriuretic-peptide",
      "query": "\"Atrial Natriuretic Peptide\"[tiab] OR \"Nesiritide\"[tiab] OR \"Natrecor\"[tiab] OR \"BNP-32\"[tiab] OR \"brain natriuretic peptide\"[tiab]",
      "query_terms": [
        "Atrial Natriuretic Peptide",
        "Nesiritide",
        "Natrecor",
        "BNP-32",
        "brain natriuretic peptide"
      ],
      "excluded_terms": [
        {
          "term": "ANP",
          "reason": "too-short"
        }
      ],
      "total_all_years": 23415,
      "total_in_window": 19556,
      "name_only_total": 11113,
      "synonym_contribution": 0.525,
      "applied_context_total": 9005,
      "applied_context_share": 0.385,
      "first_year_in_window": 2000,
      "publications_2016_2020": 4249,
      "publications_2021_2025": 4580,
      "growth_ratio_5y": 1.08,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 367,
        "2001": 408,
        "2002": 440,
        "2003": 466,
        "2004": 518,
        "2005": 647,
        "2006": 638,
        "2007": 703,
        "2008": 708,
        "2009": 693,
        "2010": 728,
        "2011": 754,
        "2012": 738,
        "2013": 817,
        "2014": 836,
        "2015": 854,
        "2016": 826,
        "2017": 795,
        "2018": 820,
        "2019": 814,
        "2020": 994,
        "2021": 1027,
        "2022": 1010,
        "2023": 872,
        "2024": 842,
        "2025": 829,
        "2026": 412
      }
    },
    {
      "slug": "endothelin-1",
      "name": "Endothelin-1",
      "category": "other",
      "url": "https://peptahub.com/peptides/endothelin-1",
      "query": "\"Endothelin-1\"[tiab] OR \"Big Endothelin-1\"[tiab] OR \"Preproendothelin-1 (mature)\"[tiab]",
      "query_terms": [
        "Endothelin-1",
        "Big Endothelin-1",
        "Preproendothelin-1 (mature)"
      ],
      "excluded_terms": [
        {
          "term": "ET-1",
          "reason": "too-short"
        }
      ],
      "total_all_years": 19900,
      "total_in_window": 15460,
      "name_only_total": 19900,
      "synonym_contribution": 0,
      "applied_context_total": 7332,
      "applied_context_share": 0.368,
      "first_year_in_window": 2000,
      "publications_2016_2020": 2669,
      "publications_2021_2025": 2106,
      "growth_ratio_5y": 0.79,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 806,
        "2001": 719,
        "2002": 668,
        "2003": 620,
        "2004": 711,
        "2005": 660,
        "2006": 655,
        "2007": 625,
        "2008": 660,
        "2009": 598,
        "2010": 632,
        "2011": 608,
        "2012": 600,
        "2013": 634,
        "2014": 659,
        "2015": 589,
        "2016": 601,
        "2017": 526,
        "2018": 502,
        "2019": 506,
        "2020": 534,
        "2021": 487,
        "2022": 436,
        "2023": 370,
        "2024": 390,
        "2025": 423,
        "2026": 241
      }
    },
    {
      "slug": "bradykinin",
      "name": "Bradykinin",
      "category": "other",
      "url": "https://peptahub.com/peptides/bradykinin",
      "query": "\"Bradykinin\"[tiab] OR \"Kallidin-9\"[tiab] OR \"Bradykinin (1-9)\"[tiab]",
      "query_terms": [
        "Bradykinin",
        "Kallidin-9",
        "Bradykinin (1-9)"
      ],
      "excluded_terms": [
        {
          "term": "BK",
          "reason": "too-short"
        }
      ],
      "total_all_years": 19306,
      "total_in_window": 9578,
      "name_only_total": 19306,
      "synonym_contribution": 0,
      "applied_context_total": 6066,
      "applied_context_share": 0.314,
      "first_year_in_window": 2000,
      "publications_2016_2020": 1471,
      "publications_2021_2025": 1231,
      "growth_ratio_5y": 0.84,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 566,
        "2001": 576,
        "2002": 544,
        "2003": 530,
        "2004": 447,
        "2005": 451,
        "2006": 443,
        "2007": 417,
        "2008": 393,
        "2009": 347,
        "2010": 377,
        "2011": 348,
        "2012": 298,
        "2013": 342,
        "2014": 347,
        "2015": 321,
        "2016": 328,
        "2017": 273,
        "2018": 274,
        "2019": 283,
        "2020": 313,
        "2021": 325,
        "2022": 255,
        "2023": 219,
        "2024": 219,
        "2025": 213,
        "2026": 129
      }
    },
    {
      "slug": "cgrp",
      "name": "CGRP",
      "category": "other",
      "url": "https://peptahub.com/peptides/cgrp",
      "query": "\"CGRP\"[tiab] OR \"Calcitonin Gene-Related Peptide\"[tiab] OR \"α-CGRP\"[tiab] OR \"CGRP-I\"[tiab] OR \"Human CGRP\"[tiab]",
      "query_terms": [
        "CGRP",
        "Calcitonin Gene-Related Peptide",
        "α-CGRP",
        "CGRP-I",
        "Human CGRP"
      ],
      "excluded_terms": [],
      "total_all_years": 17242,
      "total_in_window": 13113,
      "name_only_total": 13363,
      "synonym_contribution": 0.225,
      "applied_context_total": 6797,
      "applied_context_share": 0.394,
      "first_year_in_window": 2000,
      "publications_2016_2020": 2518,
      "publications_2021_2025": 3871,
      "growth_ratio_5y": 1.54,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound. The query also leans on a short acronym, so treat the count as an upper bound.",
      "by_year": {
        "2000": 354,
        "2001": 397,
        "2002": 347,
        "2003": 357,
        "2004": 384,
        "2005": 384,
        "2006": 378,
        "2007": 385,
        "2008": 385,
        "2009": 363,
        "2010": 396,
        "2011": 385,
        "2012": 372,
        "2013": 411,
        "2014": 386,
        "2015": 380,
        "2016": 402,
        "2017": 452,
        "2018": 474,
        "2019": 532,
        "2020": 658,
        "2021": 736,
        "2022": 693,
        "2023": 705,
        "2024": 820,
        "2025": 917,
        "2026": 660
      }
    },
    {
      "slug": "npy",
      "name": "NPY",
      "category": "other",
      "url": "https://peptahub.com/peptides/npy",
      "query": "\"NPY\"[tiab] OR \"Neuropeptide Y\"[tiab] OR \"NPY (human, rat)\"[tiab] OR \"neuropeptide tyrosine\"[tiab]",
      "query_terms": [
        "NPY",
        "Neuropeptide Y",
        "NPY (human, rat)",
        "neuropeptide tyrosine"
      ],
      "excluded_terms": [],
      "total_all_years": 17177,
      "total_in_window": 12169,
      "name_only_total": 12262,
      "synonym_contribution": 0.286,
      "applied_context_total": 5038,
      "applied_context_share": 0.293,
      "first_year_in_window": 2000,
      "publications_2016_2020": 2163,
      "publications_2021_2025": 2002,
      "growth_ratio_5y": 0.93,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound. The query also leans on a short acronym, so treat the count as an upper bound.",
      "by_year": {
        "2000": 521,
        "2001": 467,
        "2002": 474,
        "2003": 461,
        "2004": 486,
        "2005": 475,
        "2006": 483,
        "2007": 491,
        "2008": 485,
        "2009": 449,
        "2010": 499,
        "2011": 494,
        "2012": 489,
        "2013": 540,
        "2014": 475,
        "2015": 451,
        "2016": 445,
        "2017": 453,
        "2018": 445,
        "2019": 395,
        "2020": 425,
        "2021": 441,
        "2022": 417,
        "2023": 329,
        "2024": 384,
        "2025": 431,
        "2026": 264
      }
    },
    {
      "slug": "ghrelin",
      "name": "Ghrelin",
      "category": "muscle",
      "url": "https://peptahub.com/peptides/ghrelin",
      "query": "\"Ghrelin\"[tiab] OR \"acyl-ghrelin\"[tiab] OR \"ghrelin (1-28)\"[tiab]",
      "query_terms": [
        "Ghrelin",
        "acyl-ghrelin",
        "ghrelin (1-28)"
      ],
      "excluded_terms": [
        {
          "term": "growth hormone secretagogue endogenous",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 13007,
      "total_in_window": 15000,
      "name_only_total": 13007,
      "synonym_contribution": 0,
      "applied_context_total": 5607,
      "applied_context_share": 0.431,
      "first_year_in_window": 2000,
      "publications_2016_2020": 3375,
      "publications_2021_2025": 2774,
      "growth_ratio_5y": 0.82,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 24,
        "2001": 87,
        "2002": 181,
        "2003": 266,
        "2004": 398,
        "2005": 465,
        "2006": 580,
        "2007": 649,
        "2008": 689,
        "2009": 694,
        "2010": 711,
        "2011": 718,
        "2012": 771,
        "2013": 823,
        "2014": 730,
        "2015": 749,
        "2016": 676,
        "2017": 714,
        "2018": 682,
        "2019": 675,
        "2020": 628,
        "2021": 656,
        "2022": 606,
        "2023": 497,
        "2024": 488,
        "2025": 527,
        "2026": 316
      }
    },
    {
      "slug": "bortezomib",
      "name": "Bortezomib",
      "category": "other",
      "url": "https://peptahub.com/peptides/bortezomib",
      "query": "\"Bortezomib\"[tiab] OR \"Velcade\"[tiab] OR \"PS-341\"[tiab]",
      "query_terms": [
        "Bortezomib",
        "Velcade",
        "PS-341"
      ],
      "excluded_terms": [],
      "total_all_years": 11936,
      "total_in_window": 13533,
      "name_only_total": 11668,
      "synonym_contribution": 0.022,
      "applied_context_total": 9411,
      "applied_context_share": 0.788,
      "first_year_in_window": 2000,
      "publications_2016_2020": 3584,
      "publications_2021_2025": 3274,
      "growth_ratio_5y": 0.91,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 5,
        "2001": 18,
        "2002": 33,
        "2003": 74,
        "2004": 115,
        "2005": 218,
        "2006": 289,
        "2007": 375,
        "2008": 447,
        "2009": 509,
        "2010": 605,
        "2011": 621,
        "2012": 723,
        "2013": 739,
        "2014": 740,
        "2015": 756,
        "2016": 721,
        "2017": 709,
        "2018": 679,
        "2019": 717,
        "2020": 758,
        "2021": 730,
        "2022": 679,
        "2023": 614,
        "2024": 591,
        "2025": 660,
        "2026": 408
      }
    },
    {
      "slug": "octreotide",
      "name": "Octreotide",
      "category": "other",
      "url": "https://peptahub.com/peptides/octreotide",
      "query": "\"Octreotide\"[tiab] OR \"Sandostatin\"[tiab] OR \"SMS 201-995\"[tiab] OR \"octreotide acetate\"[tiab]",
      "query_terms": [
        "Octreotide",
        "Sandostatin",
        "SMS 201-995",
        "octreotide acetate"
      ],
      "excluded_terms": [],
      "total_all_years": 10170,
      "total_in_window": 7766,
      "name_only_total": 9296,
      "synonym_contribution": 0.086,
      "applied_context_total": 7273,
      "applied_context_share": 0.715,
      "first_year_in_window": 2000,
      "publications_2016_2020": 1445,
      "publications_2021_2025": 1352,
      "growth_ratio_5y": 0.94,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 288,
        "2001": 311,
        "2002": 302,
        "2003": 255,
        "2004": 325,
        "2005": 324,
        "2006": 283,
        "2007": 259,
        "2008": 299,
        "2009": 286,
        "2010": 297,
        "2011": 308,
        "2012": 326,
        "2013": 299,
        "2014": 274,
        "2015": 338,
        "2016": 326,
        "2017": 307,
        "2018": 264,
        "2019": 278,
        "2020": 270,
        "2021": 285,
        "2022": 262,
        "2023": 261,
        "2024": 264,
        "2025": 280,
        "2026": 195
      }
    },
    {
      "slug": "collagen-type-i",
      "name": "Collagen Type I",
      "category": "skin",
      "url": "https://peptahub.com/peptides/collagen-type-i",
      "query": "\"Collagen Type I\"[tiab]",
      "query_terms": [
        "Collagen Type I"
      ],
      "excluded_terms": [
        {
          "term": "Type I Collagen",
          "reason": "class-descriptor"
        },
        {
          "term": "Hydrolyzed Collagen I",
          "reason": "class-descriptor"
        },
        {
          "term": "Collagen Peptides (Type I)",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 10041,
      "total_in_window": 10005,
      "name_only_total": 10041,
      "synonym_contribution": 0,
      "applied_context_total": 3303,
      "applied_context_share": 0.329,
      "first_year_in_window": 2000,
      "publications_2016_2020": 2369,
      "publications_2021_2025": 2219,
      "growth_ratio_5y": 0.94,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 163,
        "2001": 172,
        "2002": 183,
        "2003": 199,
        "2004": 240,
        "2005": 303,
        "2006": 283,
        "2007": 336,
        "2008": 358,
        "2009": 334,
        "2010": 407,
        "2011": 354,
        "2012": 405,
        "2013": 461,
        "2014": 472,
        "2015": 450,
        "2016": 474,
        "2017": 488,
        "2018": 495,
        "2019": 460,
        "2020": 452,
        "2021": 477,
        "2022": 445,
        "2023": 407,
        "2024": 438,
        "2025": 452,
        "2026": 297
      }
    },
    {
      "slug": "secretin",
      "name": "Secretin",
      "category": "other",
      "url": "https://peptahub.com/peptides/secretin",
      "query": "\"Secretin\"[tiab] OR \"ChiRhoStim\"[tiab] OR \"Human Secretin\"[tiab] OR \"Synthetic Human Secretin\"[tiab]",
      "query_terms": [
        "Secretin",
        "ChiRhoStim",
        "Human Secretin",
        "Synthetic Human Secretin"
      ],
      "excluded_terms": [],
      "total_all_years": 7331,
      "total_in_window": 2232,
      "name_only_total": 7331,
      "synonym_contribution": 0,
      "applied_context_total": 1649,
      "applied_context_share": 0.225,
      "first_year_in_window": 2000,
      "publications_2016_2020": 341,
      "publications_2021_2025": 261,
      "growth_ratio_5y": 0.77,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 133,
        "2001": 120,
        "2002": 139,
        "2003": 107,
        "2004": 109,
        "2005": 98,
        "2006": 105,
        "2007": 85,
        "2008": 90,
        "2009": 82,
        "2010": 76,
        "2011": 91,
        "2012": 103,
        "2013": 103,
        "2014": 87,
        "2015": 69,
        "2016": 66,
        "2017": 78,
        "2018": 68,
        "2019": 59,
        "2020": 70,
        "2021": 60,
        "2022": 59,
        "2023": 60,
        "2024": 39,
        "2025": 43,
        "2026": 33
      }
    },
    {
      "slug": "polymyxin-b",
      "name": "Polymyxin B",
      "category": "other",
      "url": "https://peptahub.com/peptides/polymyxin-b",
      "query": "\"Polymyxin B\"[tiab] OR \"Polymyxin B sulfate\"[tiab] OR \"Aerosporin\"[tiab]",
      "query_terms": [
        "Polymyxin B",
        "Polymyxin B sulfate",
        "Aerosporin"
      ],
      "excluded_terms": [
        {
          "term": "PMB",
          "reason": "too-short"
        }
      ],
      "total_all_years": 7204,
      "total_in_window": 5296,
      "name_only_total": 7186,
      "synonym_contribution": 0.002,
      "applied_context_total": 3039,
      "applied_context_share": 0.422,
      "first_year_in_window": 2000,
      "publications_2016_2020": 1249,
      "publications_2021_2025": 1673,
      "growth_ratio_5y": 1.34,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 113,
        "2001": 79,
        "2002": 93,
        "2003": 91,
        "2004": 96,
        "2005": 115,
        "2006": 114,
        "2007": 116,
        "2008": 128,
        "2009": 139,
        "2010": 158,
        "2011": 171,
        "2012": 143,
        "2013": 180,
        "2014": 172,
        "2015": 204,
        "2016": 211,
        "2017": 231,
        "2018": 236,
        "2019": 259,
        "2020": 312,
        "2021": 316,
        "2022": 343,
        "2023": 291,
        "2024": 346,
        "2025": 377,
        "2026": 262
      }
    },
    {
      "slug": "gip",
      "name": "GIP",
      "category": "weight-loss",
      "url": "https://peptahub.com/peptides/gip",
      "query": "\"GIP\"[tiab] OR \"Glucose-dependent Insulinotropic Polypeptide\"[tiab] OR \"Gastric Inhibitory Polypeptide\"[tiab] OR \"GIP(1-42)\"[tiab]",
      "query_terms": [
        "GIP",
        "Glucose-dependent Insulinotropic Polypeptide",
        "Gastric Inhibitory Polypeptide",
        "GIP(1-42)"
      ],
      "excluded_terms": [],
      "total_all_years": 6873,
      "total_in_window": 6280,
      "name_only_total": 5757,
      "synonym_contribution": 0.162,
      "applied_context_total": 3445,
      "applied_context_share": 0.501,
      "first_year_in_window": 2000,
      "publications_2016_2020": 1266,
      "publications_2021_2025": 2336,
      "growth_ratio_5y": 1.85,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound. The query also leans on a short acronym, so treat the count as an upper bound.",
      "by_year": {
        "2000": 62,
        "2001": 66,
        "2002": 50,
        "2003": 67,
        "2004": 90,
        "2005": 67,
        "2006": 79,
        "2007": 115,
        "2008": 124,
        "2009": 135,
        "2010": 160,
        "2011": 194,
        "2012": 182,
        "2013": 202,
        "2014": 228,
        "2015": 236,
        "2016": 251,
        "2017": 227,
        "2018": 225,
        "2019": 257,
        "2020": 306,
        "2021": 294,
        "2022": 344,
        "2023": 372,
        "2024": 516,
        "2025": 810,
        "2026": 621
      }
    },
    {
      "slug": "desmopressin",
      "name": "Desmopressin",
      "category": "other",
      "url": "https://peptahub.com/peptides/desmopressin",
      "query": "\"Desmopressin\"[tiab] OR \"DDAVP\"[tiab] OR \"1-desamino-8-D-arginine vasopressin\"[tiab] OR \"Noctiva\"[tiab] OR \"Stimate\"[tiab] OR \"Nocdurna\"[tiab]",
      "query_terms": [
        "Desmopressin",
        "DDAVP",
        "1-desamino-8-D-arginine vasopressin",
        "Noctiva",
        "Stimate",
        "Nocdurna"
      ],
      "excluded_terms": [],
      "total_all_years": 5911,
      "total_in_window": 4353,
      "name_only_total": 4237,
      "synonym_contribution": 0.283,
      "applied_context_total": 3964,
      "applied_context_share": 0.671,
      "first_year_in_window": 2000,
      "publications_2016_2020": 921,
      "publications_2021_2025": 964,
      "growth_ratio_5y": 1.05,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 117,
        "2001": 136,
        "2002": 123,
        "2003": 123,
        "2004": 134,
        "2005": 127,
        "2006": 131,
        "2007": 153,
        "2008": 128,
        "2009": 145,
        "2010": 160,
        "2011": 182,
        "2012": 149,
        "2013": 184,
        "2014": 174,
        "2015": 152,
        "2016": 199,
        "2017": 171,
        "2018": 192,
        "2019": 170,
        "2020": 189,
        "2021": 199,
        "2022": 193,
        "2023": 174,
        "2024": 181,
        "2025": 217,
        "2026": 150
      }
    },
    {
      "slug": "alpha-msh",
      "name": "Alpha-MSH",
      "category": "skin",
      "url": "https://peptahub.com/peptides/alpha-msh",
      "query": "\"Alpha-MSH\"[tiab] OR \"α-MSH\"[tiab] OR \"α-Melanocyte-Stimulating Hormone\"[tiab] OR \"Melanotropin Alpha\"[tiab] OR \"Ac-ACTH(1-13)-NH2\"[tiab]",
      "query_terms": [
        "Alpha-MSH",
        "α-MSH",
        "α-Melanocyte-Stimulating Hormone",
        "Melanotropin Alpha",
        "Ac-ACTH(1-13)-NH2"
      ],
      "excluded_terms": [],
      "total_all_years": 5532,
      "total_in_window": 3721,
      "name_only_total": 4405,
      "synonym_contribution": 0.204,
      "applied_context_total": 1838,
      "applied_context_share": 0.332,
      "first_year_in_window": 2000,
      "publications_2016_2020": 662,
      "publications_2021_2025": 651,
      "growth_ratio_5y": 0.98,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 138,
        "2001": 112,
        "2002": 120,
        "2003": 173,
        "2004": 160,
        "2005": 136,
        "2006": 145,
        "2007": 141,
        "2008": 122,
        "2009": 152,
        "2010": 174,
        "2011": 162,
        "2012": 158,
        "2013": 161,
        "2014": 152,
        "2015": 129,
        "2016": 117,
        "2017": 129,
        "2018": 135,
        "2019": 138,
        "2020": 143,
        "2021": 145,
        "2022": 147,
        "2023": 120,
        "2024": 121,
        "2025": 118,
        "2026": 73
      }
    },
    {
      "slug": "liraglutide",
      "name": "Liraglutide",
      "category": "weight-loss",
      "url": "https://peptahub.com/peptides/liraglutide",
      "query": "\"Liraglutide\"[tiab] OR \"Victoza\"[tiab] OR \"Saxenda\"[tiab]",
      "query_terms": [
        "Liraglutide",
        "Victoza",
        "Saxenda"
      ],
      "excluded_terms": [],
      "total_all_years": 5526,
      "total_in_window": 6260,
      "name_only_total": 5502,
      "synonym_contribution": 0.004,
      "applied_context_total": 4237,
      "applied_context_share": 0.767,
      "first_year_in_window": 2003,
      "publications_2016_2020": 2023,
      "publications_2021_2025": 2529,
      "growth_ratio_5y": 1.25,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 4,
        "2004": 7,
        "2005": 9,
        "2006": 8,
        "2007": 16,
        "2008": 28,
        "2009": 69,
        "2010": 96,
        "2011": 117,
        "2012": 149,
        "2013": 161,
        "2014": 241,
        "2015": 332,
        "2016": 378,
        "2017": 397,
        "2018": 401,
        "2019": 433,
        "2020": 414,
        "2021": 445,
        "2022": 400,
        "2023": 432,
        "2024": 558,
        "2025": 694,
        "2026": 471
      }
    },
    {
      "slug": "semaglutide",
      "name": "Semaglutide",
      "category": "weight-loss",
      "url": "https://peptahub.com/peptides/semaglutide",
      "query": "\"Semaglutide\"[tiab] OR \"Ozempic\"[tiab] OR \"Wegovy\"[tiab] OR \"Rybelsus\"[tiab]",
      "query_terms": [
        "Semaglutide",
        "Ozempic",
        "Wegovy",
        "Rybelsus"
      ],
      "excluded_terms": [],
      "total_all_years": 5220,
      "total_in_window": 5786,
      "name_only_total": 5114,
      "synonym_contribution": 0.02,
      "applied_context_total": 3329,
      "applied_context_share": 0.638,
      "first_year_in_window": 2006,
      "publications_2016_2020": 482,
      "publications_2021_2025": 3855,
      "growth_ratio_5y": 8,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 1,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 4,
        "2013": 1,
        "2014": 2,
        "2015": 7,
        "2016": 18,
        "2017": 76,
        "2018": 116,
        "2019": 117,
        "2020": 155,
        "2021": 232,
        "2022": 328,
        "2023": 521,
        "2024": 1055,
        "2025": 1719,
        "2026": 1434
      }
    },
    {
      "slug": "cathelicidins",
      "name": "Cathelicidins",
      "category": "immune",
      "url": "https://peptahub.com/peptides/cathelicidins",
      "query": "\"Cathelicidins\"[tiab] OR \"LL-37\"[tiab] OR \"CRAMP\"[tiab] OR \"hCAP-18\"[tiab]",
      "query_terms": [
        "Cathelicidins",
        "LL-37",
        "CRAMP",
        "hCAP-18"
      ],
      "excluded_terms": [
        {
          "term": "Cathelicidin antimicrobial peptides",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 5073,
      "total_in_window": 4928,
      "name_only_total": 805,
      "synonym_contribution": 0.841,
      "applied_context_total": 1774,
      "applied_context_share": 0.35,
      "first_year_in_window": 2000,
      "publications_2016_2020": 1237,
      "publications_2021_2025": 1259,
      "growth_ratio_5y": 1.02,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 38,
        "2001": 47,
        "2002": 65,
        "2003": 73,
        "2004": 71,
        "2005": 120,
        "2006": 151,
        "2007": 121,
        "2008": 144,
        "2009": 168,
        "2010": 163,
        "2011": 198,
        "2012": 199,
        "2013": 203,
        "2014": 219,
        "2015": 252,
        "2016": 225,
        "2017": 247,
        "2018": 236,
        "2019": 246,
        "2020": 283,
        "2021": 280,
        "2022": 266,
        "2023": 207,
        "2024": 242,
        "2025": 264,
        "2026": 200
      }
    },
    {
      "slug": "defensins",
      "name": "Defensins",
      "category": "immune",
      "url": "https://peptahub.com/peptides/defensins",
      "query": "\"Defensins\"[tiab]",
      "query_terms": [
        "Defensins"
      ],
      "excluded_terms": [
        {
          "term": "Alpha-defensins",
          "reason": "class-descriptor"
        },
        {
          "term": "Beta-defensins",
          "reason": "class-descriptor"
        },
        {
          "term": "Human neutrophil peptides",
          "reason": "class-descriptor"
        },
        {
          "term": "HNPs",
          "reason": "too-short"
        },
        {
          "term": "HBDs",
          "reason": "too-short"
        }
      ],
      "total_all_years": 4517,
      "total_in_window": 4610,
      "name_only_total": 4517,
      "synonym_contribution": 0,
      "applied_context_total": 852,
      "applied_context_share": 0.189,
      "first_year_in_window": 2000,
      "publications_2016_2020": 942,
      "publications_2021_2025": 813,
      "growth_ratio_5y": 0.86,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 70,
        "2001": 80,
        "2002": 105,
        "2003": 129,
        "2004": 147,
        "2005": 183,
        "2006": 189,
        "2007": 188,
        "2008": 197,
        "2009": 196,
        "2010": 219,
        "2011": 197,
        "2012": 222,
        "2013": 213,
        "2014": 214,
        "2015": 211,
        "2016": 175,
        "2017": 195,
        "2018": 172,
        "2019": 209,
        "2020": 191,
        "2021": 169,
        "2022": 180,
        "2023": 162,
        "2024": 161,
        "2025": 141,
        "2026": 95
      }
    },
    {
      "slug": "teriparatide",
      "name": "Teriparatide",
      "category": "other",
      "url": "https://peptahub.com/peptides/teriparatide",
      "query": "\"Teriparatide\"[tiab] OR \"Forteo\"[tiab] OR \"Bonsity\"[tiab] OR \"PTH(1-34)\"[tiab] OR \"rhPTH(1-34)\"[tiab] OR \"Movymia\"[tiab]",
      "query_terms": [
        "Teriparatide",
        "Forteo",
        "Bonsity",
        "PTH(1-34)",
        "rhPTH(1-34)",
        "Movymia"
      ],
      "excluded_terms": [],
      "total_all_years": 4411,
      "total_in_window": 4363,
      "name_only_total": 2999,
      "synonym_contribution": 0.32,
      "applied_context_total": 3324,
      "applied_context_share": 0.754,
      "first_year_in_window": 2000,
      "publications_2016_2020": 1156,
      "publications_2021_2025": 1166,
      "growth_ratio_5y": 1.01,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 42,
        "2001": 49,
        "2002": 37,
        "2003": 64,
        "2004": 77,
        "2005": 90,
        "2006": 112,
        "2007": 90,
        "2008": 96,
        "2009": 120,
        "2010": 141,
        "2011": 186,
        "2012": 173,
        "2013": 174,
        "2014": 177,
        "2015": 224,
        "2016": 227,
        "2017": 239,
        "2018": 213,
        "2019": 231,
        "2020": 246,
        "2021": 253,
        "2022": 226,
        "2023": 198,
        "2024": 208,
        "2025": 281,
        "2026": 189
      }
    },
    {
      "slug": "ll-37",
      "name": "LL-37",
      "category": "immune",
      "url": "https://peptahub.com/peptides/ll-37",
      "query": "\"LL-37\"[tiab] OR \"Cathelicidin\"[tiab] OR \"hCAP-18 fragment\"[tiab]",
      "query_terms": [
        "LL-37",
        "Cathelicidin",
        "hCAP-18 fragment"
      ],
      "excluded_terms": [],
      "total_all_years": 4312,
      "total_in_window": 4856,
      "name_only_total": 2507,
      "synonym_contribution": 0.419,
      "applied_context_total": 1454,
      "applied_context_share": 0.337,
      "first_year_in_window": 2000,
      "publications_2016_2020": 1323,
      "publications_2021_2025": 1323,
      "growth_ratio_5y": 1,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 18,
        "2001": 22,
        "2002": 37,
        "2003": 42,
        "2004": 44,
        "2005": 80,
        "2006": 103,
        "2007": 93,
        "2008": 131,
        "2009": 163,
        "2010": 156,
        "2011": 222,
        "2012": 199,
        "2013": 213,
        "2014": 225,
        "2015": 252,
        "2016": 245,
        "2017": 271,
        "2018": 255,
        "2019": 255,
        "2020": 297,
        "2021": 287,
        "2022": 290,
        "2023": 236,
        "2024": 245,
        "2025": 265,
        "2026": 210
      }
    },
    {
      "slug": "pacap",
      "name": "PACAP",
      "category": "other",
      "url": "https://peptahub.com/peptides/pacap",
      "query": "\"PACAP\"[tiab] OR \"PACAP-38\"[tiab] OR \"PACAP-27\"[tiab] OR \"Pituitary Adenylate Cyclase-Activating Polypeptide\"[tiab]",
      "query_terms": [
        "PACAP",
        "PACAP-38",
        "PACAP-27",
        "Pituitary Adenylate Cyclase-Activating Polypeptide"
      ],
      "excluded_terms": [],
      "total_all_years": 4306,
      "total_in_window": 3646,
      "name_only_total": 3995,
      "synonym_contribution": 0.072,
      "applied_context_total": 1310,
      "applied_context_share": 0.304,
      "first_year_in_window": 2000,
      "publications_2016_2020": 592,
      "publications_2021_2025": 639,
      "growth_ratio_5y": 1.08,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 183,
        "2001": 154,
        "2002": 177,
        "2003": 140,
        "2004": 153,
        "2005": 117,
        "2006": 185,
        "2007": 152,
        "2008": 152,
        "2009": 116,
        "2010": 165,
        "2011": 131,
        "2012": 128,
        "2013": 129,
        "2014": 129,
        "2015": 118,
        "2016": 113,
        "2017": 105,
        "2018": 131,
        "2019": 135,
        "2020": 108,
        "2021": 151,
        "2022": 125,
        "2023": 130,
        "2024": 104,
        "2025": 129,
        "2026": 86
      }
    },
    {
      "slug": "galanin",
      "name": "Galanin",
      "category": "other",
      "url": "https://peptahub.com/peptides/galanin",
      "query": "\"Galanin\"[tiab] OR \"Galanin Neuropeptide\"[tiab] OR \"GAL1-29\"[tiab]",
      "query_terms": [
        "Galanin",
        "Galanin Neuropeptide",
        "GAL1-29"
      ],
      "excluded_terms": [
        {
          "term": "GAL",
          "reason": "too-short"
        }
      ],
      "total_all_years": 4267,
      "total_in_window": 2751,
      "name_only_total": 4267,
      "synonym_contribution": 0,
      "applied_context_total": 1210,
      "applied_context_share": 0.284,
      "first_year_in_window": 2000,
      "publications_2016_2020": 454,
      "publications_2021_2025": 372,
      "growth_ratio_5y": 0.82,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 150,
        "2001": 126,
        "2002": 106,
        "2003": 129,
        "2004": 132,
        "2005": 154,
        "2006": 113,
        "2007": 115,
        "2008": 113,
        "2009": 89,
        "2010": 120,
        "2011": 108,
        "2012": 105,
        "2013": 114,
        "2014": 111,
        "2015": 99,
        "2016": 103,
        "2017": 97,
        "2018": 76,
        "2019": 95,
        "2020": 83,
        "2021": 83,
        "2022": 102,
        "2023": 57,
        "2024": 59,
        "2025": 71,
        "2026": 41
      }
    },
    {
      "slug": "amylin",
      "name": "Amylin",
      "category": "weight-loss",
      "url": "https://peptahub.com/peptides/amylin",
      "query": "\"Amylin\"[tiab] OR \"Islet Amyloid Polypeptide\"[tiab] OR \"Amylin (1-37)\"[tiab]",
      "query_terms": [
        "Amylin",
        "Islet Amyloid Polypeptide",
        "Amylin (1-37)"
      ],
      "excluded_terms": [
        {
          "term": "IAPP",
          "reason": "too-short"
        }
      ],
      "total_all_years": 4245,
      "total_in_window": 3840,
      "name_only_total": 2809,
      "synonym_contribution": 0.338,
      "applied_context_total": 1325,
      "applied_context_share": 0.312,
      "first_year_in_window": 2000,
      "publications_2016_2020": 919,
      "publications_2021_2025": 945,
      "growth_ratio_5y": 1.03,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 86,
        "2001": 82,
        "2002": 72,
        "2003": 84,
        "2004": 81,
        "2005": 94,
        "2006": 95,
        "2007": 93,
        "2008": 103,
        "2009": 115,
        "2010": 155,
        "2011": 150,
        "2012": 153,
        "2013": 159,
        "2014": 153,
        "2015": 163,
        "2016": 163,
        "2017": 195,
        "2018": 196,
        "2019": 156,
        "2020": 209,
        "2021": 211,
        "2022": 185,
        "2023": 170,
        "2024": 173,
        "2025": 206,
        "2026": 138
      }
    },
    {
      "slug": "ghrh",
      "name": "GHRH",
      "category": "muscle",
      "url": "https://peptahub.com/peptides/ghrh",
      "query": "\"GHRH\"[tiab] OR \"Somatocrinin\"[tiab]",
      "query_terms": [
        "GHRH",
        "Somatocrinin"
      ],
      "excluded_terms": [
        {
          "term": "Growth Hormone-Releasing Hormone",
          "reason": "class-descriptor"
        },
        {
          "term": "GRF",
          "reason": "too-short"
        },
        {
          "term": "Growth Hormone-Releasing Factor",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 3916,
      "total_in_window": 2337,
      "name_only_total": 3862,
      "synonym_contribution": 0.014,
      "applied_context_total": 2072,
      "applied_context_share": 0.529,
      "first_year_in_window": 2000,
      "publications_2016_2020": 299,
      "publications_2021_2025": 294,
      "growth_ratio_5y": 0.98,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound. The query also leans on a short acronym, so treat the count as an upper bound.",
      "by_year": {
        "2000": 128,
        "2001": 131,
        "2002": 136,
        "2003": 131,
        "2004": 125,
        "2005": 129,
        "2006": 124,
        "2007": 100,
        "2008": 102,
        "2009": 102,
        "2010": 102,
        "2011": 88,
        "2012": 96,
        "2013": 90,
        "2014": 66,
        "2015": 57,
        "2016": 61,
        "2017": 57,
        "2018": 67,
        "2019": 56,
        "2020": 58,
        "2021": 67,
        "2022": 46,
        "2023": 43,
        "2024": 67,
        "2025": 71,
        "2026": 37
      }
    },
    {
      "slug": "gramicidin",
      "name": "Gramicidin",
      "category": "other",
      "url": "https://peptahub.com/peptides/gramicidin",
      "query": "\"Gramicidin\"[tiab] OR \"Gramicidin D\"[tiab] OR \"Gramicidin A/B/C\"[tiab] OR \"Gramicidin S (cyclic variant)\"[tiab]",
      "query_terms": [
        "Gramicidin",
        "Gramicidin D",
        "Gramicidin A/B/C",
        "Gramicidin S (cyclic variant)"
      ],
      "excluded_terms": [
        {
          "term": "Tyrothricin component",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 3734,
      "total_in_window": 1777,
      "name_only_total": 3734,
      "synonym_contribution": 0,
      "applied_context_total": 315,
      "applied_context_share": 0.084,
      "first_year_in_window": 2000,
      "publications_2016_2020": 272,
      "publications_2021_2025": 201,
      "growth_ratio_5y": 0.74,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 68,
        "2001": 82,
        "2002": 76,
        "2003": 88,
        "2004": 86,
        "2005": 106,
        "2006": 102,
        "2007": 91,
        "2008": 72,
        "2009": 87,
        "2010": 85,
        "2011": 72,
        "2012": 71,
        "2013": 68,
        "2014": 60,
        "2015": 55,
        "2016": 62,
        "2017": 61,
        "2018": 45,
        "2019": 46,
        "2020": 58,
        "2021": 43,
        "2022": 29,
        "2023": 34,
        "2024": 49,
        "2025": 46,
        "2026": 35
      }
    },
    {
      "slug": "peptide-yy",
      "name": "Peptide YY",
      "category": "weight-loss",
      "url": "https://peptahub.com/peptides/peptide-yy",
      "query": "\"Peptide YY\"[tiab] OR \"PYY 3-36\"[tiab] OR \"Peptide Tyrosine Tyrosine\"[tiab] OR \"PYY1-36\"[tiab] OR \"PYY3-36\"[tiab]",
      "query_terms": [
        "Peptide YY",
        "PYY 3-36",
        "Peptide Tyrosine Tyrosine",
        "PYY1-36",
        "PYY3-36"
      ],
      "excluded_terms": [
        {
          "term": "PYY",
          "reason": "too-short"
        }
      ],
      "total_all_years": 3633,
      "total_in_window": 3148,
      "name_only_total": 3115,
      "synonym_contribution": 0.143,
      "applied_context_total": 1462,
      "applied_context_share": 0.402,
      "first_year_in_window": 2000,
      "publications_2016_2020": 727,
      "publications_2021_2025": 656,
      "growth_ratio_5y": 0.9,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 77,
        "2001": 48,
        "2002": 42,
        "2003": 43,
        "2004": 75,
        "2005": 101,
        "2006": 103,
        "2007": 108,
        "2008": 116,
        "2009": 112,
        "2010": 126,
        "2011": 124,
        "2012": 139,
        "2013": 156,
        "2014": 149,
        "2015": 173,
        "2016": 147,
        "2017": 148,
        "2018": 142,
        "2019": 148,
        "2020": 142,
        "2021": 149,
        "2022": 152,
        "2023": 114,
        "2024": 115,
        "2025": 126,
        "2026": 73
      }
    },
    {
      "slug": "collagen-type-ii",
      "name": "Collagen Type II",
      "category": "other",
      "url": "https://peptahub.com/peptides/collagen-type-ii",
      "query": "\"Collagen Type II\"[tiab] OR \"Undenatured Type II Collagen\"[tiab] OR \"UC-II\"[tiab]",
      "query_terms": [
        "Collagen Type II",
        "Undenatured Type II Collagen",
        "UC-II"
      ],
      "excluded_terms": [
        {
          "term": "Type II Collagen",
          "reason": "class-descriptor"
        },
        {
          "term": "Cartilage Collagen",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 3448,
      "total_in_window": 3545,
      "name_only_total": 3367,
      "synonym_contribution": 0.023,
      "applied_context_total": 1253,
      "applied_context_share": 0.363,
      "first_year_in_window": 2000,
      "publications_2016_2020": 816,
      "publications_2021_2025": 652,
      "growth_ratio_5y": 0.8,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 36,
        "2001": 49,
        "2002": 57,
        "2003": 73,
        "2004": 79,
        "2005": 111,
        "2006": 116,
        "2007": 129,
        "2008": 124,
        "2009": 131,
        "2010": 173,
        "2011": 169,
        "2012": 179,
        "2013": 208,
        "2014": 185,
        "2015": 178,
        "2016": 188,
        "2017": 168,
        "2018": 166,
        "2019": 144,
        "2020": 150,
        "2021": 148,
        "2022": 124,
        "2023": 127,
        "2024": 123,
        "2025": 130,
        "2026": 80
      }
    },
    {
      "slug": "angiotensin-1-7",
      "name": "Angiotensin 1-7",
      "category": "other",
      "url": "https://peptahub.com/peptides/angiotensin-1-7",
      "query": "\"Angiotensin 1-7\"[tiab] OR \"Ang-(1-7)\"[tiab] OR \"Angiotensin-(1-7)\"[tiab] OR \"ANG 1-7\"[tiab]",
      "query_terms": [
        "Angiotensin 1-7",
        "Ang-(1-7)",
        "Angiotensin-(1-7)",
        "ANG 1-7"
      ],
      "excluded_terms": [],
      "total_all_years": 3429,
      "total_in_window": 3701,
      "name_only_total": 2420,
      "synonym_contribution": 0.294,
      "applied_context_total": 1574,
      "applied_context_share": 0.459,
      "first_year_in_window": 2000,
      "publications_2016_2020": 994,
      "publications_2021_2025": 1011,
      "growth_ratio_5y": 1.02,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 33,
        "2001": 32,
        "2002": 42,
        "2003": 44,
        "2004": 45,
        "2005": 61,
        "2006": 65,
        "2007": 77,
        "2008": 100,
        "2009": 81,
        "2010": 114,
        "2011": 131,
        "2012": 191,
        "2013": 189,
        "2014": 188,
        "2015": 204,
        "2016": 171,
        "2017": 184,
        "2018": 155,
        "2019": 173,
        "2020": 311,
        "2021": 263,
        "2022": 226,
        "2023": 178,
        "2024": 176,
        "2025": 168,
        "2026": 99
      }
    },
    {
      "slug": "carnosine",
      "name": "Carnosine",
      "category": "longevity",
      "url": "https://peptahub.com/peptides/carnosine",
      "query": "\"Carnosine\"[tiab] OR \"Beta-alanyl-L-histidine\"[tiab] OR \"L-Carnosine\"[tiab] OR \"β-alanyl-L-histidine\"[tiab]",
      "query_terms": [
        "Carnosine",
        "Beta-alanyl-L-histidine",
        "L-Carnosine",
        "β-alanyl-L-histidine"
      ],
      "excluded_terms": [],
      "total_all_years": 3198,
      "total_in_window": 2833,
      "name_only_total": 3182,
      "synonym_contribution": 0.005,
      "applied_context_total": 1226,
      "applied_context_share": 0.383,
      "first_year_in_window": 2000,
      "publications_2016_2020": 693,
      "publications_2021_2025": 856,
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      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
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        "2000": 56,
        "2001": 28,
        "2002": 54,
        "2003": 40,
        "2004": 47,
        "2005": 54,
        "2006": 56,
        "2007": 68,
        "2008": 65,
        "2009": 80,
        "2010": 98,
        "2011": 90,
        "2012": 100,
        "2013": 93,
        "2014": 118,
        "2015": 109,
        "2016": 117,
        "2017": 127,
        "2018": 134,
        "2019": 136,
        "2020": 179,
        "2021": 189,
        "2022": 165,
        "2023": 156,
        "2024": 174,
        "2025": 172,
        "2026": 128
      }
    },
    {
      "slug": "leuprolide",
      "name": "Leuprolide",
      "category": "other",
      "url": "https://peptahub.com/peptides/leuprolide",
      "query": "\"Leuprolide\"[tiab] OR \"Lupron\"[tiab] OR \"Lupron Depot\"[tiab] OR \"Leuprorelin\"[tiab] OR \"Eligard\"[tiab] OR \"Fensolvi\"[tiab]",
      "query_terms": [
        "Leuprolide",
        "Lupron",
        "Lupron Depot",
        "Leuprorelin",
        "Eligard",
        "Fensolvi"
      ],
      "excluded_terms": [],
      "total_all_years": 3061,
      "total_in_window": 2468,
      "name_only_total": 2340,
      "synonym_contribution": 0.236,
      "applied_context_total": 2504,
      "applied_context_share": 0.818,
      "first_year_in_window": 2000,
      "publications_2016_2020": 446,
      "publications_2021_2025": 590,
      "growth_ratio_5y": 1.32,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 81,
        "2001": 76,
        "2002": 82,
        "2003": 77,
        "2004": 77,
        "2005": 88,
        "2006": 80,
        "2007": 81,
        "2008": 72,
        "2009": 82,
        "2010": 88,
        "2011": 77,
        "2012": 93,
        "2013": 91,
        "2014": 104,
        "2015": 100,
        "2016": 83,
        "2017": 80,
        "2018": 78,
        "2019": 103,
        "2020": 102,
        "2021": 131,
        "2022": 107,
        "2023": 104,
        "2024": 111,
        "2025": 137,
        "2026": 83
      }
    },
    {
      "slug": "neurotrophin-3",
      "name": "Neurotrophin-3",
      "category": "cognitive",
      "url": "https://peptahub.com/peptides/neurotrophin-3",
      "query": "\"Neurotrophin-3\"[tiab] OR \"Neurotrophin 3\"[tiab]",
      "query_terms": [
        "Neurotrophin-3",
        "Neurotrophin 3"
      ],
      "excluded_terms": [
        {
          "term": "NT-3",
          "reason": "too-short"
        },
        {
          "term": "NT3",
          "reason": "too-short"
        }
      ],
      "total_all_years": 2916,
      "total_in_window": 2271,
      "name_only_total": 2916,
      "synonym_contribution": 0,
      "applied_context_total": 980,
      "applied_context_share": 0.336,
      "first_year_in_window": 2000,
      "publications_2016_2020": 353,
      "publications_2021_2025": 325,
      "growth_ratio_5y": 0.92,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 136,
        "2001": 104,
        "2002": 103,
        "2003": 105,
        "2004": 82,
        "2005": 103,
        "2006": 87,
        "2007": 106,
        "2008": 87,
        "2009": 96,
        "2010": 100,
        "2011": 91,
        "2012": 86,
        "2013": 97,
        "2014": 92,
        "2015": 82,
        "2016": 80,
        "2017": 66,
        "2018": 70,
        "2019": 65,
        "2020": 72,
        "2021": 72,
        "2022": 60,
        "2023": 60,
        "2024": 72,
        "2025": 61,
        "2026": 36
      }
    },
    {
      "slug": "exenatide",
      "name": "Exenatide",
      "category": "weight-loss",
      "url": "https://peptahub.com/peptides/exenatide",
      "query": "\"Exenatide\"[tiab] OR \"Byetta\"[tiab] OR \"Bydureon\"[tiab] OR \"AC-2993\"[tiab]",
      "query_terms": [
        "Exenatide",
        "Byetta",
        "Bydureon",
        "AC-2993"
      ],
      "excluded_terms": [
        {
          "term": "Exendin-4 synthetic",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 2845,
      "total_in_window": 3191,
      "name_only_total": 2819,
      "synonym_contribution": 0.009,
      "applied_context_total": 2206,
      "applied_context_share": 0.775,
      "first_year_in_window": 2002,
      "publications_2016_2020": 880,
      "publications_2021_2025": 751,
      "growth_ratio_5y": 0.85,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
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        "2001": 0,
        "2002": 1,
        "2003": 12,
        "2004": 22,
        "2005": 35,
        "2006": 59,
        "2007": 65,
        "2008": 91,
        "2009": 109,
        "2010": 132,
        "2011": 146,
        "2012": 206,
        "2013": 182,
        "2014": 190,
        "2015": 158,
        "2016": 189,
        "2017": 188,
        "2018": 169,
        "2019": 179,
        "2020": 155,
        "2021": 159,
        "2022": 119,
        "2023": 132,
        "2024": 146,
        "2025": 195,
        "2026": 152
      }
    },
    {
      "slug": "tirzepatide",
      "name": "Tirzepatide",
      "category": "weight-loss",
      "url": "https://peptahub.com/peptides/tirzepatide",
      "query": "\"Tirzepatide\"[tiab] OR \"Mounjaro\"[tiab] OR \"Zepbound\"[tiab]",
      "query_terms": [
        "Tirzepatide",
        "Mounjaro",
        "Zepbound"
      ],
      "excluded_terms": [],
      "total_all_years": 2300,
      "total_in_window": 2532,
      "name_only_total": 2266,
      "synonym_contribution": 0.015,
      "applied_context_total": 1474,
      "applied_context_share": 0.641,
      "first_year_in_window": 2006,
      "publications_2016_2020": 10,
      "publications_2021_2025": 1697,
      "growth_ratio_5y": 169.7,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 1,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 2,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 10,
        "2021": 36,
        "2022": 112,
        "2023": 224,
        "2024": 404,
        "2025": 921,
        "2026": 822
      }
    },
    {
      "slug": "motilin",
      "name": "Motilin",
      "category": "other",
      "url": "https://peptahub.com/peptides/motilin",
      "query": "\"Motilin\"[tiab] OR \"Porcine Motilin\"[tiab] OR \"Human Motilin\"[tiab] OR \"Gastrointestinal Motilin\"[tiab]",
      "query_terms": [
        "Motilin",
        "Porcine Motilin",
        "Human Motilin",
        "Gastrointestinal Motilin"
      ],
      "excluded_terms": [],
      "total_all_years": 2155,
      "total_in_window": 1166,
      "name_only_total": 2155,
      "synonym_contribution": 0,
      "applied_context_total": 865,
      "applied_context_share": 0.401,
      "first_year_in_window": 2000,
      "publications_2016_2020": 193,
      "publications_2021_2025": 312,
      "growth_ratio_5y": 1.62,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
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        "2000": 45,
        "2001": 51,
        "2002": 43,
        "2003": 32,
        "2004": 30,
        "2005": 38,
        "2006": 43,
        "2007": 42,
        "2008": 51,
        "2009": 33,
        "2010": 35,
        "2011": 32,
        "2012": 36,
        "2013": 44,
        "2014": 28,
        "2015": 44,
        "2016": 31,
        "2017": 37,
        "2018": 32,
        "2019": 40,
        "2020": 53,
        "2021": 64,
        "2022": 50,
        "2023": 63,
        "2024": 64,
        "2025": 71,
        "2026": 34
      }
    },
    {
      "slug": "nociceptin",
      "name": "Nociceptin",
      "category": "other",
      "url": "https://peptahub.com/peptides/nociceptin",
      "query": "\"Nociceptin\"[tiab] OR \"Orphanin FQ\"[tiab] OR \"N/OFQ\"[tiab] OR \"Nociceptin/Orphanin FQ\"[tiab]",
      "query_terms": [
        "Nociceptin",
        "Orphanin FQ",
        "N/OFQ",
        "Nociceptin/Orphanin FQ"
      ],
      "excluded_terms": [
        {
          "term": "OFQ",
          "reason": "too-short"
        }
      ],
      "total_all_years": 2115,
      "total_in_window": 1993,
      "name_only_total": 1972,
      "synonym_contribution": 0.068,
      "applied_context_total": 817,
      "applied_context_share": 0.386,
      "first_year_in_window": 2000,
      "publications_2016_2020": 305,
      "publications_2021_2025": 228,
      "growth_ratio_5y": 0.75,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 146,
        "2001": 113,
        "2002": 126,
        "2003": 89,
        "2004": 90,
        "2005": 84,
        "2006": 87,
        "2007": 92,
        "2008": 85,
        "2009": 93,
        "2010": 77,
        "2011": 68,
        "2012": 55,
        "2013": 70,
        "2014": 65,
        "2015": 84,
        "2016": 69,
        "2017": 44,
        "2018": 61,
        "2019": 78,
        "2020": 53,
        "2021": 54,
        "2022": 56,
        "2023": 40,
        "2024": 36,
        "2025": 42,
        "2026": 36
      }
    },
    {
      "slug": "bivalirudin",
      "name": "Bivalirudin",
      "category": "other",
      "url": "https://peptahub.com/peptides/bivalirudin",
      "query": "\"Bivalirudin\"[tiab] OR \"Angiomax\"[tiab] OR \"Angiox\"[tiab] OR \"Bivalirudin TFA\"[tiab]",
      "query_terms": [
        "Bivalirudin",
        "Angiomax",
        "Angiox",
        "Bivalirudin TFA"
      ],
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      "total_all_years": 1949,
      "total_in_window": 2192,
      "name_only_total": 1914,
      "synonym_contribution": 0.018,
      "applied_context_total": 1171,
      "applied_context_share": 0.601,
      "first_year_in_window": 2000,
      "publications_2016_2020": 524,
      "publications_2021_2025": 431,
      "growth_ratio_5y": 0.82,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
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        "2000": 11,
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        "2002": 34,
        "2003": 41,
        "2004": 60,
        "2005": 59,
        "2006": 66,
        "2007": 70,
        "2008": 76,
        "2009": 76,
        "2010": 101,
        "2011": 98,
        "2012": 104,
        "2013": 108,
        "2014": 117,
        "2015": 145,
        "2016": 132,
        "2017": 121,
        "2018": 94,
        "2019": 82,
        "2020": 95,
        "2021": 107,
        "2022": 78,
        "2023": 91,
        "2024": 77,
        "2025": 78,
        "2026": 60
      }
    },
    {
      "slug": "carfilzomib",
      "name": "Carfilzomib",
      "category": "other",
      "url": "https://peptahub.com/peptides/carfilzomib",
      "query": "\"Carfilzomib\"[tiab] OR \"Kyprolis\"[tiab] OR \"PR-171\"[tiab]",
      "query_terms": [
        "Carfilzomib",
        "Kyprolis",
        "PR-171"
      ],
      "excluded_terms": [],
      "total_all_years": 1836,
      "total_in_window": 2098,
      "name_only_total": 1828,
      "synonym_contribution": 0.004,
      "applied_context_total": 1524,
      "applied_context_share": 0.83,
      "first_year_in_window": 2006,
      "publications_2016_2020": 782,
      "publications_2021_2025": 854,
      "growth_ratio_5y": 1.09,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
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        "2013": 78,
        "2014": 97,
        "2015": 104,
        "2016": 154,
        "2017": 153,
        "2018": 143,
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        "2020": 184,
        "2021": 222,
        "2022": 146,
        "2023": 162,
        "2024": 152,
        "2025": 172,
        "2026": 96
      }
    },
    {
      "slug": "collagen-type-iii",
      "name": "Collagen Type III",
      "category": "skin",
      "url": "https://peptahub.com/peptides/collagen-type-iii",
      "query": "\"Collagen Type III\"[tiab]",
      "query_terms": [
        "Collagen Type III"
      ],
      "excluded_terms": [
        {
          "term": "Type III Collagen",
          "reason": "class-descriptor"
        },
        {
          "term": "Reticular Collagen",
          "reason": "class-descriptor"
        },
        {
          "term": "Fetal Collagen",
          "reason": "class-descriptor"
        }
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      "total_in_window": 1435,
      "name_only_total": 1693,
      "synonym_contribution": 0,
      "applied_context_total": 570,
      "applied_context_share": 0.337,
      "first_year_in_window": 2000,
      "publications_2016_2020": 330,
      "publications_2021_2025": 352,
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      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
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        "2001": 27,
        "2002": 29,
        "2003": 38,
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        "2005": 33,
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        "2007": 44,
        "2008": 53,
        "2009": 35,
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        "2011": 48,
        "2012": 54,
        "2013": 56,
        "2014": 77,
        "2015": 67,
        "2016": 52,
        "2017": 70,
        "2018": 67,
        "2019": 69,
        "2020": 72,
        "2021": 83,
        "2022": 70,
        "2023": 64,
        "2024": 70,
        "2025": 65,
        "2026": 54
      }
    },
    {
      "slug": "mgf",
      "name": "MGF",
      "category": "muscle",
      "url": "https://peptahub.com/peptides/mgf",
      "query": "\"MGF\"[tiab] OR \"Mechano Growth Factor\"[tiab] OR \"IGF-1Ec\"[tiab] OR \"IGF-1 Ec\"[tiab] OR \"PEG-MGF\"[tiab]",
      "query_terms": [
        "MGF",
        "Mechano Growth Factor",
        "IGF-1Ec",
        "IGF-1 Ec",
        "PEG-MGF"
      ],
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      "total_in_window": 1423,
      "name_only_total": 1563,
      "synonym_contribution": 0.035,
      "applied_context_total": 303,
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      "publications_2016_2020": 325,
      "publications_2021_2025": 497,
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        "2004": 14,
        "2005": 23,
        "2006": 32,
        "2007": 31,
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        "2017": 71,
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        "2023": 93,
        "2024": 94,
        "2025": 102,
        "2026": 78
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    },
    {
      "slug": "buserelin",
      "name": "Buserelin",
      "category": "other",
      "url": "https://peptahub.com/peptides/buserelin",
      "query": "\"Buserelin\"[tiab] OR \"Suprefact\"[tiab] OR \"Suprecur\"[tiab] OR \"Profact\"[tiab] OR \"Receptal\"[tiab]",
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        "Suprecur",
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      "applied_context_total": 1187,
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        "2004": 21,
        "2005": 29,
        "2006": 24,
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        "2013": 16,
        "2014": 17,
        "2015": 30,
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        "2017": 24,
        "2018": 23,
        "2019": 20,
        "2020": 26,
        "2021": 14,
        "2022": 23,
        "2023": 20,
        "2024": 23,
        "2025": 24,
        "2026": 15
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    },
    {
      "slug": "terlipressin",
      "name": "Terlipressin",
      "category": "other",
      "url": "https://peptahub.com/peptides/terlipressin",
      "query": "\"Terlipressin\"[tiab] OR \"Terlivaz\"[tiab] OR \"triglycyl-lysine-vasopressin\"[tiab] OR \"glypressin\"[tiab]",
      "query_terms": [
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        "Terlivaz",
        "triglycyl-lysine-vasopressin",
        "glypressin"
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      "total_in_window": 1223,
      "name_only_total": 1190,
      "synonym_contribution": 0.059,
      "applied_context_total": 978,
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      "first_year_in_window": 2000,
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      "publications_2021_2025": 352,
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        "2015": 46,
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        "2023": 88,
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        "2026": 45
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    },
    {
      "slug": "dulaglutide",
      "name": "Dulaglutide",
      "category": "weight-loss",
      "url": "https://peptahub.com/peptides/dulaglutide",
      "query": "\"Dulaglutide\"[tiab] OR \"Trulicity\"[tiab] OR \"LY2189265\"[tiab]",
      "query_terms": [
        "Dulaglutide",
        "Trulicity",
        "LY2189265"
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      "total_all_years": 1256,
      "total_in_window": 1405,
      "name_only_total": 1250,
      "synonym_contribution": 0.005,
      "applied_context_total": 931,
      "applied_context_share": 0.741,
      "first_year_in_window": 2006,
      "publications_2016_2020": 389,
      "publications_2021_2025": 763,
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        "2026": 175
      }
    },
    {
      "slug": "lanreotide",
      "name": "Lanreotide",
      "category": "other",
      "url": "https://peptahub.com/peptides/lanreotide",
      "query": "\"Lanreotide\"[tiab] OR \"Somatuline\"[tiab] OR \"Somatuline Depot\"[tiab] OR \"Somatuline Autogel\"[tiab] OR \"Lanreotide acetate\"[tiab]",
      "query_terms": [
        "Lanreotide",
        "Somatuline",
        "Somatuline Depot",
        "Somatuline Autogel",
        "Lanreotide acetate"
      ],
      "excluded_terms": [],
      "total_all_years": 1250,
      "total_in_window": 1258,
      "name_only_total": 1227,
      "synonym_contribution": 0.018,
      "applied_context_total": 1066,
      "applied_context_share": 0.853,
      "first_year_in_window": 2000,
      "publications_2016_2020": 299,
      "publications_2021_2025": 327,
      "growth_ratio_5y": 1.09,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 47,
        "2001": 39,
        "2002": 48,
        "2003": 31,
        "2004": 42,
        "2005": 36,
        "2006": 31,
        "2007": 23,
        "2008": 38,
        "2009": 30,
        "2010": 36,
        "2011": 26,
        "2012": 38,
        "2013": 29,
        "2014": 53,
        "2015": 44,
        "2016": 64,
        "2017": 59,
        "2018": 48,
        "2019": 60,
        "2020": 68,
        "2021": 62,
        "2022": 54,
        "2023": 49,
        "2024": 82,
        "2025": 80,
        "2026": 41
      }
    },
    {
      "slug": "rgds",
      "name": "RGDS",
      "category": "other",
      "url": "https://peptahub.com/peptides/rgds",
      "query": "\"RGDS\"[tiab] OR \"Arginylglycylaspartylserine\"[tiab] OR \"RGD-Ser\"[tiab] OR \"RGDS tetrapeptide\"[tiab]",
      "query_terms": [
        "RGDS",
        "Arginylglycylaspartylserine",
        "RGD-Ser",
        "RGDS tetrapeptide"
      ],
      "excluded_terms": [
        {
          "term": "Arg-Gly-Asp-Ser",
          "reason": "residue-sequence"
        }
      ],
      "total_all_years": 1150,
      "total_in_window": 689,
      "name_only_total": 1148,
      "synonym_contribution": 0.002,
      "applied_context_total": 209,
      "applied_context_share": 0.182,
      "first_year_in_window": 2000,
      "publications_2016_2020": 127,
      "publications_2021_2025": 97,
      "growth_ratio_5y": 0.76,
      "reliability": "low",
      "reliability_note": "The compound name is a short acronym or a family term, so title/abstract matching can capture unrelated records.",
      "by_year": {
        "2000": 27,
        "2001": 25,
        "2002": 29,
        "2003": 25,
        "2004": 21,
        "2005": 26,
        "2006": 29,
        "2007": 32,
        "2008": 27,
        "2009": 31,
        "2010": 31,
        "2011": 28,
        "2012": 29,
        "2013": 33,
        "2014": 33,
        "2015": 33,
        "2016": 26,
        "2017": 27,
        "2018": 20,
        "2019": 26,
        "2020": 28,
        "2021": 23,
        "2022": 20,
        "2023": 15,
        "2024": 19,
        "2025": 20,
        "2026": 6
      }
    },
    {
      "slug": "eptifibatide",
      "name": "Eptifibatide",
      "category": "other",
      "url": "https://peptahub.com/peptides/eptifibatide",
      "query": "\"Eptifibatide\"[tiab] OR \"Integrilin\"[tiab] OR \"L-739758\"[tiab]",
      "query_terms": [
        "Eptifibatide",
        "Integrilin",
        "L-739758"
      ],
      "excluded_terms": [
        {
          "term": "cyclic RGD peptide",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 1126,
      "total_in_window": 1147,
      "name_only_total": 1070,
      "synonym_contribution": 0.05,
      "applied_context_total": 809,
      "applied_context_share": 0.718,
      "first_year_in_window": 2000,
      "publications_2016_2020": 125,
      "publications_2021_2025": 143,
      "growth_ratio_5y": 1.14,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 55,
        "2001": 70,
        "2002": 74,
        "2003": 73,
        "2004": 82,
        "2005": 54,
        "2006": 51,
        "2007": 40,
        "2008": 40,
        "2009": 56,
        "2010": 53,
        "2011": 46,
        "2012": 47,
        "2013": 45,
        "2014": 43,
        "2015": 30,
        "2016": 30,
        "2017": 25,
        "2018": 22,
        "2019": 29,
        "2020": 19,
        "2021": 36,
        "2022": 31,
        "2023": 26,
        "2024": 23,
        "2025": 27,
        "2026": 20
      }
    },
    {
      "slug": "thymosin-beta-4",
      "name": "Thymosin Beta-4",
      "category": "recovery",
      "url": "https://peptahub.com/peptides/thymosin-beta-4",
      "query": "\"Thymosin Beta-4\"[tiab] OR \"Timbetasin\"[tiab] OR \"Thymosin β4\"[tiab] OR \"TMSB4X protein\"[tiab]",
      "query_terms": [
        "Thymosin Beta-4",
        "Timbetasin",
        "Thymosin β4",
        "TMSB4X protein"
      ],
      "excluded_terms": [
        {
          "term": "TB4",
          "reason": "too-short"
        }
      ],
      "total_all_years": 1126,
      "total_in_window": 1011,
      "name_only_total": 599,
      "synonym_contribution": 0.468,
      "applied_context_total": 397,
      "applied_context_share": 0.353,
      "first_year_in_window": 2000,
      "publications_2016_2020": 224,
      "publications_2021_2025": 191,
      "growth_ratio_5y": 0.85,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 14,
        "2001": 18,
        "2002": 17,
        "2003": 26,
        "2004": 25,
        "2005": 21,
        "2006": 27,
        "2007": 54,
        "2008": 23,
        "2009": 28,
        "2010": 51,
        "2011": 47,
        "2012": 69,
        "2013": 60,
        "2014": 44,
        "2015": 52,
        "2016": 52,
        "2017": 48,
        "2018": 58,
        "2019": 36,
        "2020": 30,
        "2021": 51,
        "2022": 41,
        "2023": 44,
        "2024": 18,
        "2025": 37,
        "2026": 20
      }
    },
    {
      "slug": "cecropin",
      "name": "Cecropin",
      "category": "immune",
      "url": "https://peptahub.com/peptides/cecropin",
      "query": "\"Cecropin\"[tiab] OR \"Cecropin A\"[tiab] OR \"Cecropin B\"[tiab] OR \"Cecropin P1\"[tiab]",
      "query_terms": [
        "Cecropin",
        "Cecropin A",
        "Cecropin B",
        "Cecropin P1"
      ],
      "excluded_terms": [
        {
          "term": "Insect cecropins",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 1100,
      "total_in_window": 970,
      "name_only_total": 1100,
      "synonym_contribution": 0,
      "applied_context_total": 199,
      "applied_context_share": 0.181,
      "first_year_in_window": 2000,
      "publications_2016_2020": 227,
      "publications_2021_2025": 238,
      "growth_ratio_5y": 1.05,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 31,
        "2001": 28,
        "2002": 26,
        "2003": 23,
        "2004": 27,
        "2005": 22,
        "2006": 31,
        "2007": 21,
        "2008": 29,
        "2009": 31,
        "2010": 32,
        "2011": 34,
        "2012": 35,
        "2013": 32,
        "2014": 52,
        "2015": 33,
        "2016": 43,
        "2017": 52,
        "2018": 42,
        "2019": 43,
        "2020": 47,
        "2021": 47,
        "2022": 52,
        "2023": 53,
        "2024": 41,
        "2025": 45,
        "2026": 18
      }
    },
    {
      "slug": "romidepsin",
      "name": "Romidepsin",
      "category": "other",
      "url": "https://peptahub.com/peptides/romidepsin",
      "query": "\"Romidepsin\"[tiab] OR \"Istodax\"[tiab] OR \"FK228\"[tiab] OR \"FR901228\"[tiab] OR \"NSC-630176\"[tiab]",
      "query_terms": [
        "Romidepsin",
        "Istodax",
        "FK228",
        "FR901228",
        "NSC-630176"
      ],
      "excluded_terms": [
        {
          "term": "depsipeptide",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 1081,
      "total_in_window": 1199,
      "name_only_total": 818,
      "synonym_contribution": 0.243,
      "applied_context_total": 768,
      "applied_context_share": 0.71,
      "first_year_in_window": 2000,
      "publications_2016_2020": 340,
      "publications_2021_2025": 309,
      "growth_ratio_5y": 0.91,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 8,
        "2001": 10,
        "2002": 14,
        "2003": 16,
        "2004": 28,
        "2005": 30,
        "2006": 27,
        "2007": 35,
        "2008": 34,
        "2009": 30,
        "2010": 46,
        "2011": 56,
        "2012": 40,
        "2013": 43,
        "2014": 43,
        "2015": 65,
        "2016": 79,
        "2017": 60,
        "2018": 55,
        "2019": 79,
        "2020": 67,
        "2021": 83,
        "2022": 64,
        "2023": 48,
        "2024": 57,
        "2025": 57,
        "2026": 25
      }
    },
    {
      "slug": "nesfatin-1",
      "name": "Nesfatin-1",
      "category": "weight-loss",
      "url": "https://peptahub.com/peptides/nesfatin-1",
      "query": "\"Nesfatin-1\"[tiab] OR \"NUCB2/Nesfatin-1\"[tiab] OR \"NEFA/Nesfatin-1\"[tiab] OR \"Nucleobindin-2 Fragment\"[tiab]",
      "query_terms": [
        "Nesfatin-1",
        "NUCB2/Nesfatin-1",
        "NEFA/Nesfatin-1",
        "Nucleobindin-2 Fragment"
      ],
      "excluded_terms": [],
      "total_all_years": 893,
      "total_in_window": 1022,
      "name_only_total": 893,
      "synonym_contribution": 0,
      "applied_context_total": 334,
      "applied_context_share": 0.374,
      "first_year_in_window": 2006,
      "publications_2016_2020": 337,
      "publications_2021_2025": 309,
      "growth_ratio_5y": 0.92,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 3,
        "2007": 7,
        "2008": 9,
        "2009": 21,
        "2010": 25,
        "2011": 28,
        "2012": 48,
        "2013": 73,
        "2014": 58,
        "2015": 68,
        "2016": 55,
        "2017": 68,
        "2018": 65,
        "2019": 74,
        "2020": 75,
        "2021": 68,
        "2022": 71,
        "2023": 59,
        "2024": 63,
        "2025": 48,
        "2026": 36
      }
    },
    {
      "slug": "enfuvirtide",
      "name": "Enfuvirtide",
      "category": "other",
      "url": "https://peptahub.com/peptides/enfuvirtide",
      "query": "\"Enfuvirtide\"[tiab] OR \"Fuzeon\"[tiab] OR \"DP-178\"[tiab]",
      "query_terms": [
        "Enfuvirtide",
        "Fuzeon",
        "DP-178"
      ],
      "excluded_terms": [
        {
          "term": "T-20",
          "reason": "too-short"
        }
      ],
      "total_all_years": 878,
      "total_in_window": 938,
      "name_only_total": 828,
      "synonym_contribution": 0.057,
      "applied_context_total": 554,
      "applied_context_share": 0.631,
      "first_year_in_window": 2000,
      "publications_2016_2020": 85,
      "publications_2021_2025": 57,
      "growth_ratio_5y": 0.67,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 1,
        "2001": 3,
        "2002": 7,
        "2003": 59,
        "2004": 80,
        "2005": 69,
        "2006": 75,
        "2007": 86,
        "2008": 72,
        "2009": 79,
        "2010": 71,
        "2011": 53,
        "2012": 50,
        "2013": 37,
        "2014": 32,
        "2015": 22,
        "2016": 23,
        "2017": 17,
        "2018": 12,
        "2019": 22,
        "2020": 11,
        "2021": 11,
        "2022": 14,
        "2023": 11,
        "2024": 9,
        "2025": 12,
        "2026": 0
      }
    },
    {
      "slug": "collagen-peptides",
      "name": "Collagen Peptides",
      "category": "skin",
      "url": "https://peptahub.com/peptides/collagen-peptides",
      "query": "\"Collagen Peptides\"[tiab]",
      "query_terms": [
        "Collagen Peptides"
      ],
      "excluded_terms": [
        {
          "term": "Hydrolyzed Collagen",
          "reason": "class-descriptor"
        },
        {
          "term": "Collagen Hydrolysate",
          "reason": "class-descriptor"
        },
        {
          "term": "HC",
          "reason": "too-short"
        },
        {
          "term": "Type I Collagen Peptides",
          "reason": "class-descriptor"
        },
        {
          "term": "Type II Collagen Peptides",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 857,
      "total_in_window": 843,
      "name_only_total": 857,
      "synonym_contribution": 0,
      "applied_context_total": 328,
      "applied_context_share": 0.383,
      "first_year_in_window": 2000,
      "publications_2016_2020": 200,
      "publications_2021_2025": 397,
      "growth_ratio_5y": 1.99,
      "reliability": "low",
      "reliability_note": "The compound name is a short acronym or a family term, so title/abstract matching can capture unrelated records.",
      "by_year": {
        "2000": 6,
        "2001": 3,
        "2002": 4,
        "2003": 4,
        "2004": 4,
        "2005": 5,
        "2006": 2,
        "2007": 5,
        "2008": 11,
        "2009": 14,
        "2010": 17,
        "2011": 18,
        "2012": 22,
        "2013": 19,
        "2014": 25,
        "2015": 33,
        "2016": 22,
        "2017": 40,
        "2018": 37,
        "2019": 46,
        "2020": 55,
        "2021": 49,
        "2022": 65,
        "2023": 75,
        "2024": 89,
        "2025": 119,
        "2026": 54
      }
    },
    {
      "slug": "pasireotide",
      "name": "Pasireotide",
      "category": "other",
      "url": "https://peptahub.com/peptides/pasireotide",
      "query": "\"Pasireotide\"[tiab] OR \"Signifor\"[tiab] OR \"SOM230\"[tiab] OR \"Signifor LAR\"[tiab] OR \"Pasireotide diaspartate\"[tiab]",
      "query_terms": [
        "Pasireotide",
        "Signifor",
        "SOM230",
        "Signifor LAR",
        "Pasireotide diaspartate"
      ],
      "excluded_terms": [],
      "total_all_years": 831,
      "total_in_window": 941,
      "name_only_total": 760,
      "synonym_contribution": 0.085,
      "applied_context_total": 705,
      "applied_context_share": 0.848,
      "first_year_in_window": 2002,
      "publications_2016_2020": 300,
      "publications_2021_2025": 251,
      "growth_ratio_5y": 0.84,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 2,
        "2003": 3,
        "2004": 9,
        "2005": 22,
        "2006": 11,
        "2007": 18,
        "2008": 15,
        "2009": 25,
        "2010": 27,
        "2011": 21,
        "2012": 39,
        "2013": 45,
        "2014": 67,
        "2015": 60,
        "2016": 63,
        "2017": 49,
        "2018": 63,
        "2019": 61,
        "2020": 64,
        "2021": 53,
        "2022": 47,
        "2023": 34,
        "2024": 60,
        "2025": 57,
        "2026": 26
      }
    },
    {
      "slug": "magainin",
      "name": "Magainin",
      "category": "immune",
      "url": "https://peptahub.com/peptides/magainin",
      "query": "\"Magainin\"[tiab] OR \"Magainin-2\"[tiab] OR \"Magainin 2a\"[tiab] OR \"MSI-78 (analog)\"[tiab] OR \"Pexiganan (analog)\"[tiab]",
      "query_terms": [
        "Magainin",
        "Magainin-2",
        "Magainin 2a",
        "MSI-78 (analog)",
        "Pexiganan (analog)"
      ],
      "excluded_terms": [],
      "total_all_years": 743,
      "total_in_window": 639,
      "name_only_total": 743,
      "synonym_contribution": 0,
      "applied_context_total": 115,
      "applied_context_share": 0.155,
      "first_year_in_window": 2000,
      "publications_2016_2020": 122,
      "publications_2021_2025": 107,
      "growth_ratio_5y": 0.88,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 25,
        "2001": 28,
        "2002": 23,
        "2003": 22,
        "2004": 22,
        "2005": 21,
        "2006": 31,
        "2007": 23,
        "2008": 23,
        "2009": 27,
        "2010": 25,
        "2011": 30,
        "2012": 21,
        "2013": 23,
        "2014": 33,
        "2015": 27,
        "2016": 22,
        "2017": 20,
        "2018": 27,
        "2019": 26,
        "2020": 27,
        "2021": 25,
        "2022": 28,
        "2023": 17,
        "2024": 16,
        "2025": 21,
        "2026": 6
      }
    },
    {
      "slug": "lixisenatide",
      "name": "Lixisenatide",
      "category": "weight-loss",
      "url": "https://peptahub.com/peptides/lixisenatide",
      "query": "\"Lixisenatide\"[tiab] OR \"Adlyxin\"[tiab] OR \"Lyxumia\"[tiab] OR \"AVE0010\"[tiab]",
      "query_terms": [
        "Lixisenatide",
        "Adlyxin",
        "Lyxumia",
        "AVE0010"
      ],
      "excluded_terms": [],
      "total_all_years": 721,
      "total_in_window": 831,
      "name_only_total": 718,
      "synonym_contribution": 0.004,
      "applied_context_total": 574,
      "applied_context_share": 0.796,
      "first_year_in_window": 2006,
      "publications_2016_2020": 382,
      "publications_2021_2025": 250,
      "growth_ratio_5y": 0.65,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 1,
        "2007": 0,
        "2008": 2,
        "2009": 1,
        "2010": 3,
        "2011": 3,
        "2012": 11,
        "2013": 32,
        "2014": 55,
        "2015": 39,
        "2016": 69,
        "2017": 96,
        "2018": 77,
        "2019": 79,
        "2020": 61,
        "2021": 50,
        "2022": 40,
        "2023": 45,
        "2024": 49,
        "2025": 66,
        "2026": 52
      }
    },
    {
      "slug": "ghrp-6",
      "name": "GHRP-6",
      "category": "muscle",
      "url": "https://peptahub.com/peptides/ghrp-6",
      "query": "\"GHRP-6\"[tiab] OR \"Growth Hormone Releasing Peptide-6\"[tiab] OR \"SK&F 110679\"[tiab]",
      "query_terms": [
        "GHRP-6",
        "Growth Hormone Releasing Peptide-6",
        "SK&F 110679"
      ],
      "excluded_terms": [],
      "total_all_years": 679,
      "total_in_window": 612,
      "name_only_total": 636,
      "synonym_contribution": 0.063,
      "applied_context_total": 422,
      "applied_context_share": 0.622,
      "first_year_in_window": 2000,
      "publications_2016_2020": 118,
      "publications_2021_2025": 68,
      "growth_ratio_5y": 0.58,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 12,
        "2001": 16,
        "2002": 15,
        "2003": 18,
        "2004": 18,
        "2005": 19,
        "2006": 23,
        "2007": 31,
        "2008": 29,
        "2009": 26,
        "2010": 28,
        "2011": 43,
        "2012": 36,
        "2013": 31,
        "2014": 38,
        "2015": 31,
        "2016": 25,
        "2017": 23,
        "2018": 27,
        "2019": 26,
        "2020": 17,
        "2021": 19,
        "2022": 13,
        "2023": 11,
        "2024": 11,
        "2025": 14,
        "2026": 12
      }
    },
    {
      "slug": "deltorphin",
      "name": "Deltorphin",
      "category": "other",
      "url": "https://peptahub.com/peptides/deltorphin",
      "query": "\"Deltorphin\"[tiab] OR \"Deltorphin I\"[tiab] OR \"Deltorphin II\"[tiab] OR \"Deltorphin A\"[tiab] OR \"Dermenkephalin\"[tiab]",
      "query_terms": [
        "Deltorphin",
        "Deltorphin I",
        "Deltorphin II",
        "Deltorphin A",
        "Dermenkephalin"
      ],
      "excluded_terms": [],
      "total_all_years": 653,
      "total_in_window": 349,
      "name_only_total": 633,
      "synonym_contribution": 0.031,
      "applied_context_total": 261,
      "applied_context_share": 0.4,
      "first_year_in_window": 2000,
      "publications_2016_2020": 28,
      "publications_2021_2025": 22,
      "growth_ratio_5y": 0.79,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 36,
        "2001": 28,
        "2002": 20,
        "2003": 28,
        "2004": 21,
        "2005": 20,
        "2006": 19,
        "2007": 17,
        "2008": 23,
        "2009": 15,
        "2010": 11,
        "2011": 15,
        "2012": 11,
        "2013": 9,
        "2014": 13,
        "2015": 13,
        "2016": 5,
        "2017": 8,
        "2018": 5,
        "2019": 1,
        "2020": 9,
        "2021": 4,
        "2022": 3,
        "2023": 6,
        "2024": 7,
        "2025": 2,
        "2026": 0
      }
    },
    {
      "slug": "cetrorelix",
      "name": "Cetrorelix",
      "category": "other",
      "url": "https://peptahub.com/peptides/cetrorelix",
      "query": "\"Cetrorelix\"[tiab] OR \"Cetrotide\"[tiab] OR \"Cetrorelix acetate\"[tiab] OR \"SB-75\"[tiab] OR \"Cetrolix\"[tiab]",
      "query_terms": [
        "Cetrorelix",
        "Cetrotide",
        "Cetrorelix acetate",
        "SB-75",
        "Cetrolix"
      ],
      "excluded_terms": [],
      "total_all_years": 643,
      "total_in_window": 605,
      "name_only_total": 574,
      "synonym_contribution": 0.107,
      "applied_context_total": 494,
      "applied_context_share": 0.768,
      "first_year_in_window": 2000,
      "publications_2016_2020": 80,
      "publications_2021_2025": 77,
      "growth_ratio_5y": 0.96,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 34,
        "2001": 30,
        "2002": 29,
        "2003": 31,
        "2004": 30,
        "2005": 35,
        "2006": 33,
        "2007": 20,
        "2008": 36,
        "2009": 32,
        "2010": 22,
        "2011": 28,
        "2012": 26,
        "2013": 18,
        "2014": 15,
        "2015": 15,
        "2016": 14,
        "2017": 15,
        "2018": 15,
        "2019": 18,
        "2020": 18,
        "2021": 17,
        "2022": 15,
        "2023": 15,
        "2024": 14,
        "2025": 16,
        "2026": 14
      }
    },
    {
      "slug": "cerebrolysin",
      "name": "Cerebrolysin",
      "category": "cognitive",
      "url": "https://peptahub.com/peptides/cerebrolysin",
      "query": "\"Cerebrolysin\"[tiab] OR \"FPE 1070\"[tiab]",
      "query_terms": [
        "Cerebrolysin",
        "FPE 1070"
      ],
      "excluded_terms": [],
      "total_all_years": 629,
      "total_in_window": 587,
      "name_only_total": 629,
      "synonym_contribution": 0,
      "applied_context_total": 496,
      "applied_context_share": 0.789,
      "first_year_in_window": 2000,
      "publications_2016_2020": 151,
      "publications_2021_2025": 179,
      "growth_ratio_5y": 1.19,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 21,
        "2001": 9,
        "2002": 11,
        "2003": 8,
        "2004": 7,
        "2005": 12,
        "2006": 14,
        "2007": 11,
        "2008": 12,
        "2009": 11,
        "2010": 18,
        "2011": 19,
        "2012": 16,
        "2013": 22,
        "2014": 23,
        "2015": 24,
        "2016": 30,
        "2017": 31,
        "2018": 24,
        "2019": 36,
        "2020": 30,
        "2021": 32,
        "2022": 22,
        "2023": 43,
        "2024": 35,
        "2025": 47,
        "2026": 19
      }
    },
    {
      "slug": "thymosin-alpha-1",
      "name": "Thymosin Alpha-1",
      "category": "immune",
      "url": "https://peptahub.com/peptides/thymosin-alpha-1",
      "query": "\"Thymosin Alpha-1\"[tiab] OR \"Thymalfasin\"[tiab] OR \"Zadaxin\"[tiab]",
      "query_terms": [
        "Thymosin Alpha-1",
        "Thymalfasin",
        "Zadaxin"
      ],
      "excluded_terms": [
        {
          "term": "Tα1",
          "reason": "too-short"
        },
        {
          "term": "TA-1",
          "reason": "too-short"
        }
      ],
      "total_all_years": 626,
      "total_in_window": 296,
      "name_only_total": 578,
      "synonym_contribution": 0.077,
      "applied_context_total": 325,
      "applied_context_share": 0.519,
      "first_year_in_window": 2000,
      "publications_2016_2020": 63,
      "publications_2021_2025": 63,
      "growth_ratio_5y": 1,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 11,
        "2001": 3,
        "2002": 9,
        "2003": 13,
        "2004": 17,
        "2005": 10,
        "2006": 5,
        "2007": 16,
        "2008": 12,
        "2009": 13,
        "2010": 13,
        "2011": 12,
        "2012": 7,
        "2013": 7,
        "2014": 1,
        "2015": 12,
        "2016": 5,
        "2017": 10,
        "2018": 16,
        "2019": 13,
        "2020": 19,
        "2021": 14,
        "2022": 8,
        "2023": 19,
        "2024": 13,
        "2025": 9,
        "2026": 9
      }
    },
    {
      "slug": "melanotan-ii",
      "name": "Melanotan II",
      "category": "skin",
      "url": "https://peptahub.com/peptides/melanotan-ii",
      "query": "\"Melanotan II\"[tiab] OR \"MT-II\"[tiab] OR \"Melanotan 2\"[tiab]",
      "query_terms": [
        "Melanotan II",
        "MT-II",
        "Melanotan 2"
      ],
      "excluded_terms": [
        {
          "term": "MT-2",
          "reason": "too-short"
        }
      ],
      "total_all_years": 623,
      "total_in_window": 501,
      "name_only_total": 194,
      "synonym_contribution": 0.689,
      "applied_context_total": 242,
      "applied_context_share": 0.388,
      "first_year_in_window": 2000,
      "publications_2016_2020": 65,
      "publications_2021_2025": 52,
      "growth_ratio_5y": 0.8,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 26,
        "2001": 16,
        "2002": 25,
        "2003": 31,
        "2004": 21,
        "2005": 41,
        "2006": 28,
        "2007": 34,
        "2008": 26,
        "2009": 19,
        "2010": 22,
        "2011": 14,
        "2012": 17,
        "2013": 23,
        "2014": 19,
        "2015": 17,
        "2016": 11,
        "2017": 11,
        "2018": 18,
        "2019": 7,
        "2020": 18,
        "2021": 18,
        "2022": 12,
        "2023": 9,
        "2024": 9,
        "2025": 4,
        "2026": 5
      }
    },
    {
      "slug": "tb-500",
      "name": "TB-500",
      "category": "recovery",
      "url": "https://peptahub.com/peptides/tb-500",
      "query": "\"TB-500\"[tiab] OR \"Thymosin Beta-4\"[tiab]",
      "query_terms": [
        "TB-500",
        "Thymosin Beta-4"
      ],
      "excluded_terms": [
        {
          "term": "Tβ4",
          "reason": "too-short"
        }
      ],
      "total_all_years": 612,
      "total_in_window": 463,
      "name_only_total": 16,
      "synonym_contribution": 0.974,
      "applied_context_total": 208,
      "applied_context_share": 0.34,
      "first_year_in_window": 2000,
      "publications_2016_2020": 109,
      "publications_2021_2025": 86,
      "growth_ratio_5y": 0.79,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 6,
        "2001": 9,
        "2002": 6,
        "2003": 14,
        "2004": 11,
        "2005": 10,
        "2006": 10,
        "2007": 35,
        "2008": 9,
        "2009": 11,
        "2010": 25,
        "2011": 18,
        "2012": 24,
        "2013": 22,
        "2014": 20,
        "2015": 25,
        "2016": 28,
        "2017": 25,
        "2018": 20,
        "2019": 20,
        "2020": 16,
        "2021": 27,
        "2022": 12,
        "2023": 17,
        "2024": 12,
        "2025": 18,
        "2026": 13
      }
    },
    {
      "slug": "obestatin",
      "name": "Obestatin",
      "category": "weight-loss",
      "url": "https://peptahub.com/peptides/obestatin",
      "query": "\"Obestatin\"[tiab] OR \"Obestatin-23\"[tiab] OR \"Ghrelin Gene Product\"[tiab] OR \"GPR39 Ligand\"[tiab]",
      "query_terms": [
        "Obestatin",
        "Obestatin-23",
        "Ghrelin Gene Product",
        "GPR39 Ligand"
      ],
      "excluded_terms": [],
      "total_all_years": 609,
      "total_in_window": 722,
      "name_only_total": 607,
      "synonym_contribution": 0.003,
      "applied_context_total": 228,
      "applied_context_share": 0.374,
      "first_year_in_window": 2002,
      "publications_2016_2020": 173,
      "publications_2021_2025": 62,
      "growth_ratio_5y": 0.36,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 1,
        "2003": 0,
        "2004": 0,
        "2005": 1,
        "2006": 30,
        "2007": 55,
        "2008": 63,
        "2009": 60,
        "2010": 57,
        "2011": 50,
        "2012": 43,
        "2013": 50,
        "2014": 40,
        "2015": 33,
        "2016": 39,
        "2017": 51,
        "2018": 37,
        "2019": 26,
        "2020": 20,
        "2021": 19,
        "2022": 20,
        "2023": 10,
        "2024": 8,
        "2025": 5,
        "2026": 4
      }
    },
    {
      "slug": "vilon",
      "name": "Vilon",
      "category": "immune",
      "url": "https://peptahub.com/peptides/vilon",
      "query": "\"Vilon\"[tiab] OR \"Lys-Glu\"[tiab] OR \"KE dipeptide\"[tiab] OR \"Vilon dipeptide\"[tiab]",
      "query_terms": [
        "Vilon",
        "Lys-Glu",
        "KE dipeptide",
        "Vilon dipeptide"
      ],
      "excluded_terms": [],
      "total_all_years": 593,
      "total_in_window": 383,
      "name_only_total": 62,
      "synonym_contribution": 0.895,
      "applied_context_total": 104,
      "applied_context_share": 0.175,
      "first_year_in_window": 2000,
      "publications_2016_2020": 70,
      "publications_2021_2025": 57,
      "growth_ratio_5y": 0.81,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 12,
        "2001": 18,
        "2002": 22,
        "2003": 16,
        "2004": 16,
        "2005": 18,
        "2006": 13,
        "2007": 12,
        "2008": 22,
        "2009": 8,
        "2010": 11,
        "2011": 18,
        "2012": 16,
        "2013": 17,
        "2014": 20,
        "2015": 13,
        "2016": 17,
        "2017": 12,
        "2018": 13,
        "2019": 10,
        "2020": 18,
        "2021": 10,
        "2022": 14,
        "2023": 14,
        "2024": 11,
        "2025": 8,
        "2026": 4
      }
    },
    {
      "slug": "ziconotide",
      "name": "Ziconotide",
      "category": "other",
      "url": "https://peptahub.com/peptides/ziconotide",
      "query": "\"Ziconotide\"[tiab] OR \"Prialt\"[tiab] OR \"SNX-111\"[tiab] OR \"omega-conotoxin MVIIA\"[tiab] OR \"MVIIA\"[tiab]",
      "query_terms": [
        "Ziconotide",
        "Prialt",
        "SNX-111",
        "omega-conotoxin MVIIA",
        "MVIIA"
      ],
      "excluded_terms": [],
      "total_all_years": 578,
      "total_in_window": 527,
      "name_only_total": 337,
      "synonym_contribution": 0.417,
      "applied_context_total": 322,
      "applied_context_share": 0.557,
      "first_year_in_window": 2000,
      "publications_2016_2020": 100,
      "publications_2021_2025": 85,
      "growth_ratio_5y": 0.85,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 25,
        "2001": 15,
        "2002": 17,
        "2003": 10,
        "2004": 12,
        "2005": 17,
        "2006": 25,
        "2007": 19,
        "2008": 27,
        "2009": 22,
        "2010": 21,
        "2011": 26,
        "2012": 22,
        "2013": 21,
        "2014": 20,
        "2015": 29,
        "2016": 15,
        "2017": 23,
        "2018": 20,
        "2019": 20,
        "2020": 22,
        "2021": 21,
        "2022": 12,
        "2023": 14,
        "2024": 19,
        "2025": 19,
        "2026": 14
      }
    },
    {
      "slug": "thymulin",
      "name": "Thymulin",
      "category": "immune",
      "url": "https://peptahub.com/peptides/thymulin",
      "query": "\"Thymulin\"[tiab] OR \"Facteur Thymique Sérique\"[tiab] OR \"serum thymic factor\"[tiab]",
      "query_terms": [
        "Thymulin",
        "Facteur Thymique Sérique",
        "serum thymic factor"
      ],
      "excluded_terms": [
        {
          "term": "FTS",
          "reason": "too-short"
        }
      ],
      "total_all_years": 547,
      "total_in_window": 161,
      "name_only_total": 374,
      "synonym_contribution": 0.316,
      "applied_context_total": 222,
      "applied_context_share": 0.406,
      "first_year_in_window": 2000,
      "publications_2016_2020": 19,
      "publications_2021_2025": 8,
      "growth_ratio_5y": 0.42,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 16,
        "2001": 9,
        "2002": 12,
        "2003": 10,
        "2004": 9,
        "2005": 12,
        "2006": 11,
        "2007": 7,
        "2008": 5,
        "2009": 6,
        "2010": 5,
        "2011": 7,
        "2012": 5,
        "2013": 6,
        "2014": 7,
        "2015": 6,
        "2016": 3,
        "2017": 2,
        "2018": 3,
        "2019": 6,
        "2020": 5,
        "2021": 2,
        "2022": 2,
        "2023": 4,
        "2024": 0,
        "2025": 0,
        "2026": 1
      }
    },
    {
      "slug": "kyotorphin",
      "name": "Kyotorphin",
      "category": "other",
      "url": "https://peptahub.com/peptides/kyotorphin",
      "query": "\"Kyotorphin\"[tiab] OR \"Tyr-Arg\"[tiab] OR \"L-Tyrosyl-L-Arginine\"[tiab]",
      "query_terms": [
        "Kyotorphin",
        "Tyr-Arg",
        "L-Tyrosyl-L-Arginine"
      ],
      "excluded_terms": [
        {
          "term": "KTP",
          "reason": "too-short"
        }
      ],
      "total_all_years": 536,
      "total_in_window": 275,
      "name_only_total": 210,
      "synonym_contribution": 0.608,
      "applied_context_total": 104,
      "applied_context_share": 0.194,
      "first_year_in_window": 2000,
      "publications_2016_2020": 44,
      "publications_2021_2025": 45,
      "growth_ratio_5y": 1.02,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 18,
        "2001": 6,
        "2002": 10,
        "2003": 15,
        "2004": 18,
        "2005": 8,
        "2006": 18,
        "2007": 13,
        "2008": 11,
        "2009": 9,
        "2010": 11,
        "2011": 9,
        "2012": 11,
        "2013": 12,
        "2014": 4,
        "2015": 9,
        "2016": 12,
        "2017": 13,
        "2018": 7,
        "2019": 5,
        "2020": 7,
        "2021": 7,
        "2022": 6,
        "2023": 9,
        "2024": 13,
        "2025": 10,
        "2026": 4
      }
    },
    {
      "slug": "dermorphin",
      "name": "Dermorphin",
      "category": "other",
      "url": "https://peptahub.com/peptides/dermorphin",
      "query": "\"Dermorphin\"[tiab] OR \"H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2\"[tiab] OR \"Frog Skin Opioid Peptide\"[tiab]",
      "query_terms": [
        "Dermorphin",
        "H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2",
        "Frog Skin Opioid Peptide"
      ],
      "excluded_terms": [],
      "total_all_years": 535,
      "total_in_window": 217,
      "name_only_total": 535,
      "synonym_contribution": 0,
      "applied_context_total": 189,
      "applied_context_share": 0.353,
      "first_year_in_window": 2000,
      "publications_2016_2020": 36,
      "publications_2021_2025": 25,
      "growth_ratio_5y": 0.69,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 9,
        "2001": 9,
        "2002": 14,
        "2003": 15,
        "2004": 5,
        "2005": 14,
        "2006": 9,
        "2007": 13,
        "2008": 8,
        "2009": 9,
        "2010": 5,
        "2011": 9,
        "2012": 5,
        "2013": 13,
        "2014": 11,
        "2015": 6,
        "2016": 13,
        "2017": 4,
        "2018": 5,
        "2019": 7,
        "2020": 7,
        "2021": 4,
        "2022": 5,
        "2023": 4,
        "2024": 6,
        "2025": 6,
        "2026": 2
      }
    },
    {
      "slug": "humanin",
      "name": "Humanin",
      "category": "longevity",
      "url": "https://peptahub.com/peptides/humanin",
      "query": "\"Humanin\"[tiab]",
      "query_terms": [
        "Humanin"
      ],
      "excluded_terms": [
        {
          "term": "HN",
          "reason": "too-short"
        },
        {
          "term": "HNG",
          "reason": "too-short"
        },
        {
          "term": "Mitochondrial Derived Peptide",
          "reason": "class-descriptor"
        },
        {
          "term": "MDP",
          "reason": "too-short"
        },
        {
          "term": "MOTS-c family",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 533,
      "total_in_window": 604,
      "name_only_total": 533,
      "synonym_contribution": 0,
      "applied_context_total": 236,
      "applied_context_share": 0.443,
      "first_year_in_window": 2001,
      "publications_2016_2020": 159,
      "publications_2021_2025": 203,
      "growth_ratio_5y": 1.28,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 0,
        "2001": 4,
        "2002": 6,
        "2003": 12,
        "2004": 15,
        "2005": 13,
        "2006": 15,
        "2007": 7,
        "2008": 13,
        "2009": 17,
        "2010": 14,
        "2011": 13,
        "2012": 13,
        "2013": 21,
        "2014": 21,
        "2015": 20,
        "2016": 21,
        "2017": 30,
        "2018": 31,
        "2019": 36,
        "2020": 41,
        "2021": 44,
        "2022": 40,
        "2023": 41,
        "2024": 41,
        "2025": 37,
        "2026": 38
      }
    },
    {
      "slug": "collagen-dipeptide",
      "name": "Collagen Dipeptide",
      "category": "skin",
      "url": "https://peptahub.com/peptides/collagen-dipeptide",
      "query": "\"Collagen Dipeptide\"[tiab] OR \"Pro-Hyp\"[tiab] OR \"Hyp-Gly\"[tiab] OR \"Prolyl-Hydroxyproline\"[tiab] OR \"Hydroxyproline-Glycine\"[tiab]",
      "query_terms": [
        "Collagen Dipeptide",
        "Pro-Hyp",
        "Hyp-Gly",
        "Prolyl-Hydroxyproline",
        "Hydroxyproline-Glycine"
      ],
      "excluded_terms": [
        {
          "term": "Collagen hydrolysate fragments",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 499,
      "total_in_window": 393,
      "name_only_total": 0,
      "synonym_contribution": 1,
      "applied_context_total": 106,
      "applied_context_share": 0.212,
      "first_year_in_window": 2000,
      "publications_2016_2020": 81,
      "publications_2021_2025": 80,
      "growth_ratio_5y": 0.99,
      "reliability": "low",
      "reliability_note": "The compound name is a short acronym or a family term, so title/abstract matching can capture unrelated records.",
      "by_year": {
        "2000": 16,
        "2001": 11,
        "2002": 14,
        "2003": 12,
        "2004": 14,
        "2005": 15,
        "2006": 11,
        "2007": 14,
        "2008": 17,
        "2009": 13,
        "2010": 15,
        "2011": 18,
        "2012": 15,
        "2013": 9,
        "2014": 11,
        "2015": 16,
        "2016": 14,
        "2017": 19,
        "2018": 16,
        "2019": 17,
        "2020": 15,
        "2021": 17,
        "2022": 16,
        "2023": 22,
        "2024": 13,
        "2025": 12,
        "2026": 11
      }
    },
    {
      "slug": "thymus-extract",
      "name": "Thymus Extract",
      "category": "immune",
      "url": "https://peptahub.com/peptides/thymus-extract",
      "query": "\"Thymus Extract\"[tiab] OR \"Thymostimulin\"[tiab]",
      "query_terms": [
        "Thymus Extract",
        "Thymostimulin"
      ],
      "excluded_terms": [
        {
          "term": "thymic extract",
          "reason": "class-descriptor"
        },
        {
          "term": "thymic polypeptides",
          "reason": "class-descriptor"
        },
        {
          "term": "calf thymus extract",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 483,
      "total_in_window": 38,
      "name_only_total": 296,
      "synonym_contribution": 0.387,
      "applied_context_total": 218,
      "applied_context_share": 0.451,
      "first_year_in_window": 2000,
      "publications_2016_2020": 1,
      "publications_2021_2025": 5,
      "growth_ratio_5y": 5,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 2,
        "2001": 2,
        "2002": 6,
        "2003": 3,
        "2004": 1,
        "2005": 1,
        "2006": 3,
        "2007": 0,
        "2008": 2,
        "2009": 0,
        "2010": 4,
        "2011": 1,
        "2012": 1,
        "2013": 1,
        "2014": 2,
        "2015": 1,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 1,
        "2021": 2,
        "2022": 1,
        "2023": 1,
        "2024": 1,
        "2025": 0,
        "2026": 2
      }
    },
    {
      "slug": "dsip",
      "name": "DSIP",
      "category": "sleep",
      "url": "https://peptahub.com/peptides/dsip",
      "query": "\"DSIP\"[tiab] OR \"Delta Sleep-Inducing Peptide\"[tiab]",
      "query_terms": [
        "DSIP",
        "Delta Sleep-Inducing Peptide"
      ],
      "excluded_terms": [],
      "total_all_years": 462,
      "total_in_window": 113,
      "name_only_total": 346,
      "synonym_contribution": 0.251,
      "applied_context_total": 178,
      "applied_context_share": 0.385,
      "first_year_in_window": 2000,
      "publications_2016_2020": 6,
      "publications_2021_2025": 7,
      "growth_ratio_5y": 1.17,
      "reliability": "low",
      "reliability_note": "The compound name is a short acronym or a family term, so title/abstract matching can capture unrelated records.",
      "by_year": {
        "2000": 4,
        "2001": 11,
        "2002": 7,
        "2003": 15,
        "2004": 10,
        "2005": 2,
        "2006": 7,
        "2007": 4,
        "2008": 6,
        "2009": 5,
        "2010": 2,
        "2011": 4,
        "2012": 5,
        "2013": 5,
        "2014": 9,
        "2015": 3,
        "2016": 2,
        "2017": 2,
        "2018": 1,
        "2019": 0,
        "2020": 1,
        "2021": 3,
        "2022": 0,
        "2023": 1,
        "2024": 2,
        "2025": 1,
        "2026": 1
      }
    },
    {
      "slug": "ss-31",
      "name": "SS-31",
      "category": "longevity",
      "url": "https://peptahub.com/peptides/ss-31",
      "query": "\"SS-31\"[tiab] OR \"Elamipretide\"[tiab] OR \"Bendavia\"[tiab] OR \"MTP-131\"[tiab]",
      "query_terms": [
        "SS-31",
        "Elamipretide",
        "Bendavia",
        "MTP-131"
      ],
      "excluded_terms": [],
      "total_all_years": 458,
      "total_in_window": 514,
      "name_only_total": 280,
      "synonym_contribution": 0.389,
      "applied_context_total": 311,
      "applied_context_share": 0.679,
      "first_year_in_window": 2000,
      "publications_2016_2020": 136,
      "publications_2021_2025": 243,
      "growth_ratio_5y": 1.79,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 1,
        "2001": 0,
        "2002": 0,
        "2003": 1,
        "2004": 1,
        "2005": 1,
        "2006": 2,
        "2007": 2,
        "2008": 2,
        "2009": 3,
        "2010": 2,
        "2011": 8,
        "2012": 5,
        "2013": 10,
        "2014": 20,
        "2015": 18,
        "2016": 18,
        "2017": 26,
        "2018": 31,
        "2019": 30,
        "2020": 31,
        "2021": 40,
        "2022": 40,
        "2023": 32,
        "2024": 59,
        "2025": 72,
        "2026": 59
      }
    },
    {
      "slug": "pramlintide",
      "name": "Pramlintide",
      "category": "weight-loss",
      "url": "https://peptahub.com/peptides/pramlintide",
      "query": "\"Pramlintide\"[tiab] OR \"Symlin\"[tiab] OR \"AC137\"[tiab] OR \"Pramlintide acetate\"[tiab]",
      "query_terms": [
        "Pramlintide",
        "Symlin",
        "AC137",
        "Pramlintide acetate"
      ],
      "excluded_terms": [],
      "total_all_years": 453,
      "total_in_window": 457,
      "name_only_total": 443,
      "synonym_contribution": 0.022,
      "applied_context_total": 343,
      "applied_context_share": 0.757,
      "first_year_in_window": 2000,
      "publications_2016_2020": 93,
      "publications_2021_2025": 87,
      "growth_ratio_5y": 0.94,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 5,
        "2001": 6,
        "2002": 13,
        "2003": 15,
        "2004": 14,
        "2005": 22,
        "2006": 25,
        "2007": 24,
        "2008": 25,
        "2009": 21,
        "2010": 16,
        "2011": 12,
        "2012": 8,
        "2013": 16,
        "2014": 26,
        "2015": 17,
        "2016": 16,
        "2017": 23,
        "2018": 24,
        "2019": 12,
        "2020": 18,
        "2021": 26,
        "2022": 14,
        "2023": 9,
        "2024": 22,
        "2025": 16,
        "2026": 12
      }
    },
    {
      "slug": "thymopentin",
      "name": "Thymopentin",
      "category": "immune",
      "url": "https://peptahub.com/peptides/thymopentin",
      "query": "\"Thymopentin\"[tiab] OR \"Timopentina\"[tiab] OR \"Thymopentin (32-36)\"[tiab]",
      "query_terms": [
        "Thymopentin",
        "Timopentina",
        "Thymopentin (32-36)"
      ],
      "excluded_terms": [
        {
          "term": "TP-5",
          "reason": "too-short"
        },
        {
          "term": "Arg-Lys-Asp-Val-Tyr",
          "reason": "residue-sequence"
        }
      ],
      "total_all_years": 445,
      "total_in_window": 178,
      "name_only_total": 445,
      "synonym_contribution": 0,
      "applied_context_total": 254,
      "applied_context_share": 0.571,
      "first_year_in_window": 2000,
      "publications_2016_2020": 35,
      "publications_2021_2025": 44,
      "growth_ratio_5y": 1.26,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 3,
        "2001": 2,
        "2002": 1,
        "2003": 5,
        "2004": 2,
        "2005": 3,
        "2006": 8,
        "2007": 6,
        "2008": 10,
        "2009": 4,
        "2010": 6,
        "2011": 7,
        "2012": 6,
        "2013": 6,
        "2014": 13,
        "2015": 13,
        "2016": 10,
        "2017": 5,
        "2018": 5,
        "2019": 8,
        "2020": 7,
        "2021": 12,
        "2022": 6,
        "2023": 8,
        "2024": 7,
        "2025": 11,
        "2026": 4
      }
    },
    {
      "slug": "thymopoietin",
      "name": "Thymopoietin",
      "category": "immune",
      "url": "https://peptahub.com/peptides/thymopoietin",
      "query": "\"Thymopoietin\"[tiab] OR \"Thymopoietin II\"[tiab] OR \"Thymopoietin III\"[tiab] OR \"Lamina-associated polypeptide 2\"[tiab]",
      "query_terms": [
        "Thymopoietin",
        "Thymopoietin II",
        "Thymopoietin III",
        "Lamina-associated polypeptide 2"
      ],
      "excluded_terms": [
        {
          "term": "TMPO",
          "reason": "too-short"
        }
      ],
      "total_all_years": 411,
      "total_in_window": 118,
      "name_only_total": 354,
      "synonym_contribution": 0.139,
      "applied_context_total": 102,
      "applied_context_share": 0.248,
      "first_year_in_window": 2000,
      "publications_2016_2020": 26,
      "publications_2021_2025": 29,
      "growth_ratio_5y": 1.12,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 9,
        "2001": 2,
        "2002": 4,
        "2003": 6,
        "2004": 4,
        "2005": 2,
        "2006": 4,
        "2007": 6,
        "2008": 2,
        "2009": 3,
        "2010": 3,
        "2011": 3,
        "2012": 0,
        "2013": 4,
        "2014": 4,
        "2015": 4,
        "2016": 4,
        "2017": 6,
        "2018": 4,
        "2019": 8,
        "2020": 4,
        "2021": 10,
        "2022": 4,
        "2023": 2,
        "2024": 7,
        "2025": 6,
        "2026": 3
      }
    },
    {
      "slug": "kisspeptin-10",
      "name": "Kisspeptin-10",
      "category": "sexual-health",
      "url": "https://peptahub.com/peptides/kisspeptin-10",
      "query": "\"Kisspeptin-10\"[tiab] OR \"KP-10\"[tiab] OR \"Metastin 45-54\"[tiab]",
      "query_terms": [
        "Kisspeptin-10",
        "KP-10",
        "Metastin 45-54"
      ],
      "excluded_terms": [],
      "total_all_years": 410,
      "total_in_window": 472,
      "name_only_total": 310,
      "synonym_contribution": 0.244,
      "applied_context_total": 217,
      "applied_context_share": 0.529,
      "first_year_in_window": 2000,
      "publications_2016_2020": 118,
      "publications_2021_2025": 108,
      "growth_ratio_5y": 0.92,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 1,
        "2001": 2,
        "2002": 0,
        "2003": 0,
        "2004": 4,
        "2005": 9,
        "2006": 15,
        "2007": 13,
        "2008": 18,
        "2009": 28,
        "2010": 28,
        "2011": 24,
        "2012": 21,
        "2013": 19,
        "2014": 24,
        "2015": 20,
        "2016": 18,
        "2017": 32,
        "2018": 27,
        "2019": 19,
        "2020": 22,
        "2021": 19,
        "2022": 25,
        "2023": 18,
        "2024": 17,
        "2025": 29,
        "2026": 20
      }
    },
    {
      "slug": "abaloparatide",
      "name": "Abaloparatide",
      "category": "other",
      "url": "https://peptahub.com/peptides/abaloparatide",
      "query": "\"Abaloparatide\"[tiab] OR \"Tymlos\"[tiab] OR \"BA-058\"[tiab] OR \"ITM-058\"[tiab] OR \"BIM-44058\"[tiab]",
      "query_terms": [
        "Abaloparatide",
        "Tymlos",
        "BA-058",
        "ITM-058",
        "BIM-44058"
      ],
      "excluded_terms": [],
      "total_all_years": 385,
      "total_in_window": 447,
      "name_only_total": 385,
      "synonym_contribution": 0,
      "applied_context_total": 317,
      "applied_context_share": 0.823,
      "first_year_in_window": 2000,
      "publications_2016_2020": 171,
      "publications_2021_2025": 234,
      "growth_ratio_5y": 1.37,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 1,
        "2001": 0,
        "2002": 1,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 4,
        "2015": 6,
        "2016": 18,
        "2017": 33,
        "2018": 35,
        "2019": 44,
        "2020": 41,
        "2021": 39,
        "2022": 42,
        "2023": 49,
        "2024": 48,
        "2025": 56,
        "2026": 30
      }
    },
    {
      "slug": "cortistatin",
      "name": "Cortistatin",
      "category": "immune",
      "url": "https://peptahub.com/peptides/cortistatin",
      "query": "\"Cortistatin\"[tiab] OR \"CST-14\"[tiab] OR \"CST-17\"[tiab] OR \"CST-29\"[tiab] OR \"Cortistatin-14\"[tiab] OR \"Cortistatin-29\"[tiab]",
      "query_terms": [
        "Cortistatin",
        "CST-14",
        "CST-17",
        "CST-29",
        "Cortistatin-14",
        "Cortistatin-29"
      ],
      "excluded_terms": [],
      "total_all_years": 384,
      "total_in_window": 405,
      "name_only_total": 367,
      "synonym_contribution": 0.044,
      "applied_context_total": 124,
      "applied_context_share": 0.323,
      "first_year_in_window": 2000,
      "publications_2016_2020": 82,
      "publications_2021_2025": 75,
      "growth_ratio_5y": 0.91,
      "reliability": "context-dependent",
      "reliability_note": "Endogenous or structural molecule. Most of this literature studies its normal biology, not its use as an administered compound.",
      "by_year": {
        "2000": 5,
        "2001": 7,
        "2002": 7,
        "2003": 15,
        "2004": 11,
        "2005": 18,
        "2006": 22,
        "2007": 20,
        "2008": 27,
        "2009": 16,
        "2010": 14,
        "2011": 15,
        "2012": 17,
        "2013": 14,
        "2014": 11,
        "2015": 18,
        "2016": 12,
        "2017": 17,
        "2018": 14,
        "2019": 22,
        "2020": 17,
        "2021": 11,
        "2022": 14,
        "2023": 13,
        "2024": 19,
        "2025": 18,
        "2026": 11
      }
    },
    {
      "slug": "gonadorelin",
      "name": "Gonadorelin",
      "category": "sexual-health",
      "url": "https://peptahub.com/peptides/gonadorelin",
      "query": "\"Gonadorelin\"[tiab]",
      "query_terms": [
        "Gonadorelin"
      ],
      "excluded_terms": [
        {
          "term": "GnRH",
          "reason": "too-short"
        },
        {
          "term": "LHRH",
          "reason": "too-short"
        },
        {
          "term": "Gonadotropin-Releasing Hormone",
          "reason": "class-descriptor"
        },
        {
          "term": "Luteinizing Hormone-Releasing Hormone",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 295,
      "total_in_window": 251,
      "name_only_total": 295,
      "synonym_contribution": 0,
      "applied_context_total": 218,
      "applied_context_share": 0.739,
      "first_year_in_window": 2000,
      "publications_2016_2020": 56,
      "publications_2021_2025": 76,
      "growth_ratio_5y": 1.36,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 4,
        "2001": 7,
        "2002": 4,
        "2003": 5,
        "2004": 6,
        "2005": 3,
        "2006": 1,
        "2007": 12,
        "2008": 7,
        "2009": 9,
        "2010": 6,
        "2011": 9,
        "2012": 9,
        "2013": 7,
        "2014": 9,
        "2015": 12,
        "2016": 11,
        "2017": 12,
        "2018": 6,
        "2019": 14,
        "2020": 13,
        "2021": 13,
        "2022": 10,
        "2023": 21,
        "2024": 16,
        "2025": 16,
        "2026": 9
      }
    },
    {
      "slug": "hexarelin",
      "name": "Hexarelin",
      "category": "muscle",
      "url": "https://peptahub.com/peptides/hexarelin",
      "query": "\"Hexarelin\"[tiab] OR \"Examorelin\"[tiab]",
      "query_terms": [
        "Hexarelin",
        "Examorelin"
      ],
      "excluded_terms": [
        {
          "term": "HEX",
          "reason": "too-short"
        }
      ],
      "total_all_years": 291,
      "total_in_window": 194,
      "name_only_total": 289,
      "synonym_contribution": 0.007,
      "applied_context_total": 194,
      "applied_context_share": 0.667,
      "first_year_in_window": 2000,
      "publications_2016_2020": 26,
      "publications_2021_2025": 14,
      "growth_ratio_5y": 0.54,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 22,
        "2001": 18,
        "2002": 15,
        "2003": 14,
        "2004": 11,
        "2005": 8,
        "2006": 8,
        "2007": 6,
        "2008": 8,
        "2009": 5,
        "2010": 8,
        "2011": 6,
        "2012": 7,
        "2013": 5,
        "2014": 7,
        "2015": 4,
        "2016": 4,
        "2017": 7,
        "2018": 7,
        "2019": 4,
        "2020": 4,
        "2021": 7,
        "2022": 2,
        "2023": 3,
        "2024": 1,
        "2025": 1,
        "2026": 2
      }
    },
    {
      "slug": "ghk",
      "name": "GHK",
      "category": "skin",
      "url": "https://peptahub.com/peptides/ghk",
      "query": "\"GHK\"[tiab] OR \"Glycyl-L-histidyl-L-lysine\"[tiab] OR \"GHK tripeptide\"[tiab]",
      "query_terms": [
        "GHK",
        "Glycyl-L-histidyl-L-lysine",
        "GHK tripeptide"
      ],
      "excluded_terms": [
        {
          "term": "Gly-His-Lys",
          "reason": "residue-sequence"
        }
      ],
      "total_all_years": 282,
      "total_in_window": 248,
      "name_only_total": 257,
      "synonym_contribution": 0.089,
      "applied_context_total": 67,
      "applied_context_share": 0.238,
      "first_year_in_window": 2000,
      "publications_2016_2020": 45,
      "publications_2021_2025": 99,
      "growth_ratio_5y": 2.2,
      "reliability": "low",
      "reliability_note": "The compound name is a short acronym or a family term, so title/abstract matching can capture unrelated records.",
      "by_year": {
        "2000": 4,
        "2001": 4,
        "2002": 3,
        "2003": 4,
        "2004": 2,
        "2005": 5,
        "2006": 7,
        "2007": 9,
        "2008": 4,
        "2009": 5,
        "2010": 4,
        "2011": 4,
        "2012": 6,
        "2013": 5,
        "2014": 6,
        "2015": 4,
        "2016": 7,
        "2017": 8,
        "2018": 6,
        "2019": 8,
        "2020": 16,
        "2021": 17,
        "2022": 11,
        "2023": 23,
        "2024": 17,
        "2025": 31,
        "2026": 28
      }
    },
    {
      "slug": "mif-1",
      "name": "MIF-1",
      "category": "other",
      "url": "https://peptahub.com/peptides/mif-1",
      "query": "\"MIF-1\"[tiab] OR \"Melanocyte Inhibiting Factor 1\"[tiab]",
      "query_terms": [
        "MIF-1",
        "Melanocyte Inhibiting Factor 1"
      ],
      "excluded_terms": [
        {
          "term": "Pro-Leu-Gly-NH2",
          "reason": "residue-sequence"
        },
        {
          "term": "PLG",
          "reason": "too-short"
        },
        {
          "term": "MSH release-inhibiting factor",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 277,
      "total_in_window": 88,
      "name_only_total": 277,
      "synonym_contribution": 0,
      "applied_context_total": 90,
      "applied_context_share": 0.325,
      "first_year_in_window": 2000,
      "publications_2016_2020": 13,
      "publications_2021_2025": 13,
      "growth_ratio_5y": 1,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 4,
        "2001": 6,
        "2002": 3,
        "2003": 3,
        "2004": 3,
        "2005": 4,
        "2006": 3,
        "2007": 5,
        "2008": 3,
        "2009": 5,
        "2010": 4,
        "2011": 1,
        "2012": 2,
        "2013": 3,
        "2014": 3,
        "2015": 5,
        "2016": 2,
        "2017": 1,
        "2018": 2,
        "2019": 2,
        "2020": 6,
        "2021": 4,
        "2022": 2,
        "2023": 4,
        "2024": 1,
        "2025": 2,
        "2026": 5
      }
    },
    {
      "slug": "nafarelin",
      "name": "Nafarelin",
      "category": "other",
      "url": "https://peptahub.com/peptides/nafarelin",
      "query": "\"Nafarelin\"[tiab] OR \"Synarel\"[tiab] OR \"Nafarelin acetate\"[tiab]",
      "query_terms": [
        "Nafarelin",
        "Synarel",
        "Nafarelin acetate"
      ],
      "excluded_terms": [],
      "total_all_years": 273,
      "total_in_window": 86,
      "name_only_total": 270,
      "synonym_contribution": 0.011,
      "applied_context_total": 210,
      "applied_context_share": 0.769,
      "first_year_in_window": 2000,
      "publications_2016_2020": 9,
      "publications_2021_2025": 8,
      "growth_ratio_5y": 0.89,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 15,
        "2001": 9,
        "2002": 6,
        "2003": 7,
        "2004": 3,
        "2005": 2,
        "2006": 3,
        "2007": 2,
        "2008": 2,
        "2009": 4,
        "2010": 2,
        "2011": 2,
        "2012": 6,
        "2013": 2,
        "2014": 1,
        "2015": 3,
        "2016": 1,
        "2017": 1,
        "2018": 2,
        "2019": 0,
        "2020": 5,
        "2021": 1,
        "2022": 1,
        "2023": 3,
        "2024": 2,
        "2025": 1,
        "2026": 0
      }
    },
    {
      "slug": "mots-c",
      "name": "MOTS-c",
      "category": "longevity",
      "url": "https://peptahub.com/peptides/mots-c",
      "query": "\"MOTS-c\"[tiab] OR \"Mitochondrial ORF of the Twelve S rRNA c\"[tiab]",
      "query_terms": [
        "MOTS-c",
        "Mitochondrial ORF of the Twelve S rRNA c"
      ],
      "excluded_terms": [],
      "total_all_years": 246,
      "total_in_window": 273,
      "name_only_total": 246,
      "synonym_contribution": 0,
      "applied_context_total": 133,
      "applied_context_share": 0.541,
      "first_year_in_window": 2015,
      "publications_2016_2020": 52,
      "publications_2021_2025": 179,
      "growth_ratio_5y": 3.44,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 4,
        "2016": 3,
        "2017": 4,
        "2018": 10,
        "2019": 19,
        "2020": 16,
        "2021": 35,
        "2022": 25,
        "2023": 36,
        "2024": 36,
        "2025": 47,
        "2026": 38
      }
    },
    {
      "slug": "thymalin",
      "name": "Thymalin",
      "category": "immune",
      "url": "https://peptahub.com/peptides/thymalin",
      "query": "\"Thymalin\"[tiab] OR \"Thymalin peptide bioregulator\"[tiab]",
      "query_terms": [
        "Thymalin",
        "Thymalin peptide bioregulator"
      ],
      "excluded_terms": [
        {
          "term": "Thymus extract",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 234,
      "total_in_window": 46,
      "name_only_total": 234,
      "synonym_contribution": 0,
      "applied_context_total": 136,
      "applied_context_share": 0.581,
      "first_year_in_window": 2000,
      "publications_2016_2020": 5,
      "publications_2021_2025": 6,
      "growth_ratio_5y": 1.2,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 5,
        "2001": 7,
        "2002": 5,
        "2003": 2,
        "2004": 6,
        "2005": 0,
        "2006": 1,
        "2007": 1,
        "2008": 1,
        "2009": 1,
        "2010": 1,
        "2011": 2,
        "2012": 0,
        "2013": 1,
        "2014": 0,
        "2015": 2,
        "2016": 1,
        "2017": 0,
        "2018": 1,
        "2019": 1,
        "2020": 2,
        "2021": 1,
        "2022": 2,
        "2023": 1,
        "2024": 2,
        "2025": 0,
        "2026": 0
      }
    },
    {
      "slug": "ghrp-2",
      "name": "GHRP-2",
      "category": "muscle",
      "url": "https://peptahub.com/peptides/ghrp-2",
      "query": "\"GHRP-2\"[tiab] OR \"Pralmorelin\"[tiab] OR \"GPA 748\"[tiab] OR \"Growth Hormone Releasing Peptide-2\"[tiab]",
      "query_terms": [
        "GHRP-2",
        "Pralmorelin",
        "GPA 748",
        "Growth Hormone Releasing Peptide-2"
      ],
      "excluded_terms": [],
      "total_all_years": 221,
      "total_in_window": 197,
      "name_only_total": 204,
      "synonym_contribution": 0.077,
      "applied_context_total": 162,
      "applied_context_share": 0.733,
      "first_year_in_window": 2000,
      "publications_2016_2020": 30,
      "publications_2021_2025": 14,
      "growth_ratio_5y": 0.47,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 11,
        "2001": 11,
        "2002": 9,
        "2003": 5,
        "2004": 14,
        "2005": 14,
        "2006": 5,
        "2007": 9,
        "2008": 9,
        "2009": 15,
        "2010": 13,
        "2011": 8,
        "2012": 7,
        "2013": 5,
        "2014": 8,
        "2015": 7,
        "2016": 7,
        "2017": 5,
        "2018": 6,
        "2019": 6,
        "2020": 6,
        "2021": 5,
        "2022": 3,
        "2023": 2,
        "2024": 1,
        "2025": 3,
        "2026": 3
      }
    },
    {
      "slug": "bpc-157",
      "name": "BPC-157",
      "category": "recovery",
      "url": "https://peptahub.com/peptides/bpc-157",
      "query": "\"BPC-157\"[tiab] OR \"Body Protection Compound-157\"[tiab] OR \"PL 14736\"[tiab] OR \"Bepecin\"[tiab]",
      "query_terms": [
        "BPC-157",
        "Body Protection Compound-157",
        "PL 14736",
        "Bepecin"
      ],
      "excluded_terms": [],
      "total_all_years": 214,
      "total_in_window": 206,
      "name_only_total": 211,
      "synonym_contribution": 0.014,
      "applied_context_total": 164,
      "applied_context_share": 0.766,
      "first_year_in_window": 2000,
      "publications_2016_2020": 45,
      "publications_2021_2025": 65,
      "growth_ratio_5y": 1.44,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 2,
        "2001": 9,
        "2002": 1,
        "2003": 3,
        "2004": 3,
        "2005": 4,
        "2006": 6,
        "2007": 3,
        "2008": 5,
        "2009": 10,
        "2010": 7,
        "2011": 6,
        "2012": 3,
        "2013": 5,
        "2014": 4,
        "2015": 6,
        "2016": 9,
        "2017": 11,
        "2018": 8,
        "2019": 5,
        "2020": 12,
        "2021": 19,
        "2022": 13,
        "2023": 10,
        "2024": 7,
        "2025": 16,
        "2026": 19
      }
    },
    {
      "slug": "semax",
      "name": "Semax",
      "category": "cognitive",
      "url": "https://peptahub.com/peptides/semax",
      "query": "\"Semax\"[tiab] OR \"ACTH 4-10 Pro-Gly-Pro\"[tiab]",
      "query_terms": [
        "Semax",
        "ACTH 4-10 Pro-Gly-Pro"
      ],
      "excluded_terms": [],
      "total_all_years": 206,
      "total_in_window": 196,
      "name_only_total": 206,
      "synonym_contribution": 0,
      "applied_context_total": 92,
      "applied_context_share": 0.447,
      "first_year_in_window": 2000,
      "publications_2016_2020": 28,
      "publications_2021_2025": 28,
      "growth_ratio_5y": 1,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 6,
        "2001": 10,
        "2002": 5,
        "2003": 11,
        "2004": 10,
        "2005": 8,
        "2006": 15,
        "2007": 7,
        "2008": 8,
        "2009": 9,
        "2010": 9,
        "2011": 5,
        "2012": 7,
        "2013": 11,
        "2014": 7,
        "2015": 7,
        "2016": 5,
        "2017": 9,
        "2018": 4,
        "2019": 3,
        "2020": 7,
        "2021": 9,
        "2022": 4,
        "2023": 3,
        "2024": 4,
        "2025": 8,
        "2026": 5
      }
    },
    {
      "slug": "ganirelix",
      "name": "Ganirelix",
      "category": "other",
      "url": "https://peptahub.com/peptides/ganirelix",
      "query": "\"Ganirelix\"[tiab] OR \"Antagon\"[tiab] OR \"Orgalutran\"[tiab] OR \"Ganirelix acetate\"[tiab]",
      "query_terms": [
        "Ganirelix",
        "Antagon",
        "Orgalutran",
        "Ganirelix acetate"
      ],
      "excluded_terms": [],
      "total_all_years": 204,
      "total_in_window": 207,
      "name_only_total": 189,
      "synonym_contribution": 0.074,
      "applied_context_total": 155,
      "applied_context_share": 0.76,
      "first_year_in_window": 2000,
      "publications_2016_2020": 11,
      "publications_2021_2025": 43,
      "growth_ratio_5y": 3.91,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 7,
        "2001": 15,
        "2002": 12,
        "2003": 9,
        "2004": 14,
        "2005": 20,
        "2006": 10,
        "2007": 7,
        "2008": 7,
        "2009": 8,
        "2010": 12,
        "2011": 11,
        "2012": 7,
        "2013": 4,
        "2014": 4,
        "2015": 4,
        "2016": 2,
        "2017": 0,
        "2018": 0,
        "2019": 5,
        "2020": 4,
        "2021": 8,
        "2022": 9,
        "2023": 10,
        "2024": 9,
        "2025": 7,
        "2026": 2
      }
    },
    {
      "slug": "cortexin",
      "name": "Cortexin",
      "category": "cognitive",
      "url": "https://peptahub.com/peptides/cortexin",
      "query": "\"Cortexin\"[tiab]",
      "query_terms": [
        "Cortexin"
      ],
      "excluded_terms": [
        {
          "term": "brain polypeptide complex",
          "reason": "class-descriptor"
        },
        {
          "term": "cortical polypeptides",
          "reason": "class-descriptor"
        },
        {
          "term": "cerebral cortex extract",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 202,
      "total_in_window": 192,
      "name_only_total": 202,
      "synonym_contribution": 0,
      "applied_context_total": 128,
      "applied_context_share": 0.634,
      "first_year_in_window": 2000,
      "publications_2016_2020": 48,
      "publications_2021_2025": 55,
      "growth_ratio_5y": 1.15,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 4,
        "2001": 0,
        "2002": 1,
        "2003": 0,
        "2004": 4,
        "2005": 0,
        "2006": 4,
        "2007": 7,
        "2008": 2,
        "2009": 5,
        "2010": 5,
        "2011": 12,
        "2012": 6,
        "2013": 11,
        "2014": 11,
        "2015": 7,
        "2016": 7,
        "2017": 7,
        "2018": 11,
        "2019": 11,
        "2020": 12,
        "2021": 12,
        "2022": 14,
        "2023": 11,
        "2024": 6,
        "2025": 12,
        "2026": 10
      }
    },
    {
      "slug": "sermorelin",
      "name": "Sermorelin",
      "category": "muscle",
      "url": "https://peptahub.com/peptides/sermorelin",
      "query": "\"Sermorelin\"[tiab] OR \"GRF 1-29\"[tiab] OR \"Geref\"[tiab]",
      "query_terms": [
        "Sermorelin",
        "GRF 1-29",
        "Geref"
      ],
      "excluded_terms": [],
      "total_all_years": 201,
      "total_in_window": 45,
      "name_only_total": 24,
      "synonym_contribution": 0.881,
      "applied_context_total": 89,
      "applied_context_share": 0.443,
      "first_year_in_window": 2000,
      "publications_2016_2020": 9,
      "publications_2021_2025": 9,
      "growth_ratio_5y": 1,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 3,
        "2001": 2,
        "2002": 3,
        "2003": 1,
        "2004": 3,
        "2005": 1,
        "2006": 1,
        "2007": 1,
        "2008": 0,
        "2009": 2,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 1,
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        "2015": 2,
        "2016": 2,
        "2017": 1,
        "2018": 2,
        "2019": 2,
        "2020": 2,
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        "2022": 2,
        "2023": 3,
        "2024": 1,
        "2025": 1,
        "2026": 6
      }
    },
    {
      "slug": "epithalon",
      "name": "Epithalon",
      "category": "longevity",
      "url": "https://peptahub.com/peptides/epithalon",
      "query": "\"Epithalon\"[tiab] OR \"Epitalon\"[tiab] OR \"Epithalamin\"[tiab] OR \"AEDG peptide\"[tiab]",
      "query_terms": [
        "Epithalon",
        "Epitalon",
        "Epithalamin",
        "AEDG peptide"
      ],
      "excluded_terms": [],
      "total_all_years": 166,
      "total_in_window": 137,
      "name_only_total": 56,
      "synonym_contribution": 0.663,
      "applied_context_total": 72,
      "applied_context_share": 0.434,
      "first_year_in_window": 2000,
      "publications_2016_2020": 7,
      "publications_2021_2025": 9,
      "growth_ratio_5y": 1.29,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
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        "2000": 6,
        "2001": 12,
        "2002": 21,
        "2003": 14,
        "2004": 14,
        "2005": 6,
        "2006": 8,
        "2007": 10,
        "2008": 8,
        "2009": 1,
        "2010": 1,
        "2011": 5,
        "2012": 3,
        "2013": 4,
        "2014": 3,
        "2015": 2,
        "2016": 0,
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        "2020": 5,
        "2021": 0,
        "2022": 2,
        "2023": 1,
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        "2025": 5,
        "2026": 3
      }
    },
    {
      "slug": "retatrutide",
      "name": "Retatrutide",
      "category": "weight-loss",
      "url": "https://peptahub.com/peptides/retatrutide",
      "query": "\"Retatrutide\"[tiab] OR \"LY3437943\"[tiab]",
      "query_terms": [
        "Retatrutide",
        "LY3437943"
      ],
      "excluded_terms": [
        {
          "term": "Triple G agonist",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 158,
      "total_in_window": 172,
      "name_only_total": 153,
      "synonym_contribution": 0.032,
      "applied_context_total": 102,
      "applied_context_share": 0.646,
      "first_year_in_window": 2022,
      "publications_2016_2020": 0,
      "publications_2021_2025": 123,
      "growth_ratio_5y": null,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
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        "2023": 17,
        "2024": 45,
        "2025": 59,
        "2026": 49
      }
    },
    {
      "slug": "orforglipron",
      "name": "Orforglipron",
      "category": "weight-loss",
      "url": "https://peptahub.com/peptides/orforglipron",
      "query": "\"Orforglipron\"[tiab] OR \"LY3502970\"[tiab] OR \"Foundayo\"[tiab]",
      "query_terms": [
        "Orforglipron",
        "LY3502970",
        "Foundayo"
      ],
      "excluded_terms": [
        {
          "term": "oral GLP-1 pill",
          "reason": "class-descriptor"
        },
        {
          "term": "GLP-1 pill",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 120,
      "total_in_window": 129,
      "name_only_total": 115,
      "synonym_contribution": 0.042,
      "applied_context_total": 78,
      "applied_context_share": 0.65,
      "first_year_in_window": 2006,
      "publications_2016_2020": 1,
      "publications_2021_2025": 68,
      "growth_ratio_5y": 68,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 1,
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        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
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        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
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        "2020": 1,
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        "2023": 14,
        "2024": 17,
        "2025": 33,
        "2026": 58
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    },
    {
      "slug": "mk-677",
      "name": "MK-677",
      "category": "muscle",
      "url": "https://peptahub.com/peptides/mk-677",
      "query": "\"MK-677\"[tiab] OR \"Ibutamoren\"[tiab] OR \"Ibutamoren Mesylate\"[tiab] OR \"MK-0677\"[tiab] OR \"L-163,191\"[tiab]",
      "query_terms": [
        "MK-677",
        "Ibutamoren",
        "Ibutamoren Mesylate",
        "MK-0677",
        "L-163,191"
      ],
      "excluded_terms": [],
      "total_all_years": 117,
      "total_in_window": 91,
      "name_only_total": 38,
      "synonym_contribution": 0.675,
      "applied_context_total": 68,
      "applied_context_share": 0.581,
      "first_year_in_window": 2000,
      "publications_2016_2020": 12,
      "publications_2021_2025": 22,
      "growth_ratio_5y": 1.83,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 8,
        "2001": 11,
        "2002": 3,
        "2003": 3,
        "2004": 3,
        "2005": 2,
        "2006": 3,
        "2007": 4,
        "2008": 5,
        "2009": 4,
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        "2011": 1,
        "2012": 1,
        "2013": 2,
        "2014": 1,
        "2015": 0,
        "2016": 0,
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        "2018": 5,
        "2019": 1,
        "2020": 4,
        "2021": 6,
        "2022": 6,
        "2023": 1,
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        "2025": 8,
        "2026": 5
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    },
    {
      "slug": "pt-141",
      "name": "PT-141",
      "category": "sexual-health",
      "url": "https://peptahub.com/peptides/pt-141",
      "query": "\"PT-141\"[tiab] OR \"Bremelanotide\"[tiab] OR \"Vyleesi\"[tiab]",
      "query_terms": [
        "PT-141",
        "Bremelanotide",
        "Vyleesi"
      ],
      "excluded_terms": [],
      "total_all_years": 112,
      "total_in_window": 126,
      "name_only_total": 21,
      "synonym_contribution": 0.813,
      "applied_context_total": 79,
      "applied_context_share": 0.705,
      "first_year_in_window": 2003,
      "publications_2016_2020": 24,
      "publications_2021_2025": 53,
      "growth_ratio_5y": 2.21,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 0,
        "2001": 0,
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        "2003": 2,
        "2004": 7,
        "2005": 4,
        "2006": 5,
        "2007": 7,
        "2008": 7,
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        "2010": 0,
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        "2012": 2,
        "2013": 0,
        "2014": 2,
        "2015": 2,
        "2016": 2,
        "2017": 5,
        "2018": 4,
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        "2020": 7,
        "2021": 10,
        "2022": 14,
        "2023": 8,
        "2024": 8,
        "2025": 13,
        "2026": 10
      }
    },
    {
      "slug": "cagrilintide",
      "name": "Cagrilintide",
      "category": "weight-loss",
      "url": "https://peptahub.com/peptides/cagrilintide",
      "query": "\"Cagrilintide\"[tiab] OR \"AM833\"[tiab] OR \"NN9838\"[tiab]",
      "query_terms": [
        "Cagrilintide",
        "AM833",
        "NN9838"
      ],
      "excluded_terms": [
        {
          "term": "CagriSema component",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 109,
      "total_in_window": 95,
      "name_only_total": 88,
      "synonym_contribution": 0.193,
      "applied_context_total": 73,
      "applied_context_share": 0.67,
      "first_year_in_window": 2021,
      "publications_2016_2020": 0,
      "publications_2021_2025": 63,
      "growth_ratio_5y": null,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 0,
        "2021": 8,
        "2022": 6,
        "2023": 5,
        "2024": 14,
        "2025": 30,
        "2026": 32
      }
    },
    {
      "slug": "aviptadil",
      "name": "Aviptadil",
      "category": "immune",
      "url": "https://peptahub.com/peptides/aviptadil",
      "query": "\"Aviptadil\"[tiab] OR \"RLF-100\"[tiab] OR \"Vasoactive Intestinal Peptide (synthetic)\"[tiab] OR \"Human VIP\"[tiab]",
      "query_terms": [
        "Aviptadil",
        "RLF-100",
        "Vasoactive Intestinal Peptide (synthetic)",
        "Human VIP"
      ],
      "excluded_terms": [
        {
          "term": "VIP",
          "reason": "too-short"
        }
      ],
      "total_all_years": 108,
      "total_in_window": 69,
      "name_only_total": 30,
      "synonym_contribution": 0.722,
      "applied_context_total": 30,
      "applied_context_share": 0.278,
      "first_year_in_window": 2000,
      "publications_2016_2020": 4,
      "publications_2021_2025": 29,
      "growth_ratio_5y": 7.25,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 1,
        "2001": 4,
        "2002": 0,
        "2003": 1,
        "2004": 1,
        "2005": 4,
        "2006": 4,
        "2007": 4,
        "2008": 4,
        "2009": 2,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 3,
        "2014": 2,
        "2015": 1,
        "2016": 0,
        "2017": 1,
        "2018": 1,
        "2019": 2,
        "2020": 0,
        "2021": 2,
        "2022": 6,
        "2023": 4,
        "2024": 6,
        "2025": 11,
        "2026": 5
      }
    },
    {
      "slug": "noopept",
      "name": "Noopept",
      "category": "cognitive",
      "url": "https://peptahub.com/peptides/noopept",
      "query": "\"Noopept\"[tiab] OR \"GVS-111\"[tiab] OR \"Omberacetam\"[tiab] OR \"N-phenylacetyl-L-prolylglycine ethyl ester\"[tiab]",
      "query_terms": [
        "Noopept",
        "GVS-111",
        "Omberacetam",
        "N-phenylacetyl-L-prolylglycine ethyl ester"
      ],
      "excluded_terms": [],
      "total_all_years": 107,
      "total_in_window": 99,
      "name_only_total": 83,
      "synonym_contribution": 0.224,
      "applied_context_total": 48,
      "applied_context_share": 0.449,
      "first_year_in_window": 2000,
      "publications_2016_2020": 12,
      "publications_2021_2025": 14,
      "growth_ratio_5y": 1.17,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 3,
        "2001": 3,
        "2002": 8,
        "2003": 9,
        "2004": 2,
        "2005": 4,
        "2006": 4,
        "2007": 7,
        "2008": 7,
        "2009": 6,
        "2010": 3,
        "2011": 7,
        "2012": 3,
        "2013": 2,
        "2014": 4,
        "2015": 1,
        "2016": 2,
        "2017": 0,
        "2018": 4,
        "2019": 4,
        "2020": 2,
        "2021": 5,
        "2022": 2,
        "2023": 2,
        "2024": 2,
        "2025": 3,
        "2026": 0
      }
    },
    {
      "slug": "tesamorelin",
      "name": "Tesamorelin",
      "category": "muscle",
      "url": "https://peptahub.com/peptides/tesamorelin",
      "query": "\"Tesamorelin\"[tiab] OR \"Egrifta\"[tiab] OR \"TH9507\"[tiab]",
      "query_terms": [
        "Tesamorelin",
        "Egrifta",
        "TH9507"
      ],
      "excluded_terms": [],
      "total_all_years": 103,
      "total_in_window": 109,
      "name_only_total": 93,
      "synonym_contribution": 0.097,
      "applied_context_total": 75,
      "applied_context_share": 0.728,
      "first_year_in_window": 2004,
      "publications_2016_2020": 19,
      "publications_2021_2025": 21,
      "growth_ratio_5y": 1.11,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 3,
        "2005": 5,
        "2006": 1,
        "2007": 5,
        "2008": 3,
        "2009": 1,
        "2010": 7,
        "2011": 12,
        "2012": 8,
        "2013": 5,
        "2014": 2,
        "2015": 4,
        "2016": 5,
        "2017": 5,
        "2018": 1,
        "2019": 5,
        "2020": 3,
        "2021": 6,
        "2022": 5,
        "2023": 2,
        "2024": 4,
        "2025": 4,
        "2026": 13
      }
    },
    {
      "slug": "histrelin",
      "name": "Histrelin",
      "category": "other",
      "url": "https://peptahub.com/peptides/histrelin",
      "query": "\"Histrelin\"[tiab] OR \"Supprelin LA\"[tiab] OR \"Vantas\"[tiab] OR \"Histrelin acetate\"[tiab]",
      "query_terms": [
        "Histrelin",
        "Supprelin LA",
        "Vantas",
        "Histrelin acetate"
      ],
      "excluded_terms": [],
      "total_all_years": 99,
      "total_in_window": 100,
      "name_only_total": 95,
      "synonym_contribution": 0.04,
      "applied_context_total": 79,
      "applied_context_share": 0.798,
      "first_year_in_window": 2000,
      "publications_2016_2020": 19,
      "publications_2021_2025": 33,
      "growth_ratio_5y": 1.74,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 1,
        "2001": 2,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 5,
        "2006": 1,
        "2007": 1,
        "2008": 1,
        "2009": 6,
        "2010": 8,
        "2011": 3,
        "2012": 5,
        "2013": 6,
        "2014": 3,
        "2015": 5,
        "2016": 1,
        "2017": 1,
        "2018": 7,
        "2019": 7,
        "2020": 3,
        "2021": 10,
        "2022": 3,
        "2023": 5,
        "2024": 6,
        "2025": 9,
        "2026": 1
      }
    },
    {
      "slug": "zinc-thymulin",
      "name": "Zinc Thymulin",
      "category": "skin",
      "url": "https://peptahub.com/peptides/zinc-thymulin",
      "query": "\"Zinc Thymulin\"[tiab] OR \"Zn-Thymulin\"[tiab] OR \"FTS-Zn\"[tiab] OR \"Facteur Thymique Sérique\"[tiab] OR \"thymulin zinc complex\"[tiab]",
      "query_terms": [
        "Zinc Thymulin",
        "Zn-Thymulin",
        "FTS-Zn",
        "Facteur Thymique Sérique",
        "thymulin zinc complex"
      ],
      "excluded_terms": [],
      "total_all_years": 95,
      "total_in_window": 9,
      "name_only_total": 11,
      "synonym_contribution": 0.884,
      "applied_context_total": 34,
      "applied_context_share": 0.358,
      "first_year_in_window": 2000,
      "publications_2016_2020": 0,
      "publications_2021_2025": 0,
      "growth_ratio_5y": null,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 2,
        "2001": 1,
        "2002": 2,
        "2003": 2,
        "2004": 0,
        "2005": 0,
        "2006": 1,
        "2007": 1,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 0,
        "2021": 0,
        "2022": 0,
        "2023": 0,
        "2024": 0,
        "2025": 0,
        "2026": 0
      }
    },
    {
      "slug": "ghk-cu",
      "name": "GHK-Cu",
      "category": "skin",
      "url": "https://peptahub.com/peptides/ghk-cu",
      "query": "\"GHK-Cu\"[tiab] OR \"GHK Copper\"[tiab]",
      "query_terms": [
        "GHK-Cu",
        "GHK Copper"
      ],
      "excluded_terms": [
        {
          "term": "Copper Peptide",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 74,
      "total_in_window": 79,
      "name_only_total": 74,
      "synonym_contribution": 0,
      "applied_context_total": 25,
      "applied_context_share": 0.338,
      "first_year_in_window": 2000,
      "publications_2016_2020": 18,
      "publications_2021_2025": 32,
      "growth_ratio_5y": 1.78,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 1,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 1,
        "2006": 2,
        "2007": 2,
        "2008": 2,
        "2009": 0,
        "2010": 0,
        "2011": 1,
        "2012": 1,
        "2013": 1,
        "2014": 2,
        "2015": 2,
        "2016": 3,
        "2017": 1,
        "2018": 1,
        "2019": 5,
        "2020": 8,
        "2021": 3,
        "2022": 2,
        "2023": 12,
        "2024": 7,
        "2025": 8,
        "2026": 14
      }
    },
    {
      "slug": "survodutide",
      "name": "Survodutide",
      "category": "weight-loss",
      "url": "https://peptahub.com/peptides/survodutide",
      "query": "\"Survodutide\"[tiab] OR \"BI 456906\"[tiab] OR \"BI-456906\"[tiab]",
      "query_terms": [
        "Survodutide",
        "BI 456906",
        "BI-456906"
      ],
      "excluded_terms": [],
      "total_all_years": 71,
      "total_in_window": 85,
      "name_only_total": 67,
      "synonym_contribution": 0.056,
      "applied_context_total": 51,
      "applied_context_share": 0.718,
      "first_year_in_window": 2022,
      "publications_2016_2020": 0,
      "publications_2021_2025": 62,
      "growth_ratio_5y": null,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 0,
        "2021": 0,
        "2022": 1,
        "2023": 5,
        "2024": 21,
        "2025": 35,
        "2026": 23
      }
    },
    {
      "slug": "selank",
      "name": "Selank",
      "category": "cognitive",
      "url": "https://peptahub.com/peptides/selank",
      "query": "\"Selank\"[tiab]",
      "query_terms": [
        "Selank"
      ],
      "excluded_terms": [
        {
          "term": "TP-7",
          "reason": "too-short"
        }
      ],
      "total_all_years": 68,
      "total_in_window": 69,
      "name_only_total": 68,
      "synonym_contribution": 0,
      "applied_context_total": 30,
      "applied_context_share": 0.441,
      "first_year_in_window": 2001,
      "publications_2016_2020": 18,
      "publications_2021_2025": 3,
      "growth_ratio_5y": 0.17,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 0,
        "2001": 2,
        "2002": 3,
        "2003": 2,
        "2004": 2,
        "2005": 4,
        "2006": 4,
        "2007": 2,
        "2008": 8,
        "2009": 3,
        "2010": 3,
        "2011": 3,
        "2012": 2,
        "2013": 3,
        "2014": 5,
        "2015": 1,
        "2016": 3,
        "2017": 8,
        "2018": 1,
        "2019": 3,
        "2020": 3,
        "2021": 2,
        "2022": 1,
        "2023": 0,
        "2024": 0,
        "2025": 0,
        "2026": 1
      }
    },
    {
      "slug": "kpv",
      "name": "KPV",
      "category": "immune",
      "url": "https://peptahub.com/peptides/kpv",
      "query": "\"KPV\"[tiab] OR \"α-MSH C-terminal tripeptide\"[tiab]",
      "query_terms": [
        "KPV",
        "α-MSH C-terminal tripeptide"
      ],
      "excluded_terms": [
        {
          "term": "Lys-Pro-Val",
          "reason": "residue-sequence"
        }
      ],
      "total_all_years": 65,
      "total_in_window": 69,
      "name_only_total": 65,
      "synonym_contribution": 0,
      "applied_context_total": 42,
      "applied_context_share": 0.646,
      "first_year_in_window": 2000,
      "publications_2016_2020": 12,
      "publications_2021_2025": 20,
      "growth_ratio_5y": 1.67,
      "reliability": "low",
      "reliability_note": "The compound name is a short acronym or a family term, so title/abstract matching can capture unrelated records.",
      "by_year": {
        "2000": 4,
        "2001": 1,
        "2002": 2,
        "2003": 2,
        "2004": 1,
        "2005": 3,
        "2006": 3,
        "2007": 3,
        "2008": 3,
        "2009": 1,
        "2010": 3,
        "2011": 2,
        "2012": 3,
        "2013": 0,
        "2014": 1,
        "2015": 1,
        "2016": 3,
        "2017": 3,
        "2018": 2,
        "2019": 3,
        "2020": 1,
        "2021": 3,
        "2022": 3,
        "2023": 4,
        "2024": 5,
        "2025": 5,
        "2026": 4
      }
    },
    {
      "slug": "cagrisema",
      "name": "CagriSema",
      "category": "weight-loss",
      "url": "https://peptahub.com/peptides/cagrisema",
      "query": "\"CagriSema\"[tiab] OR \"Cagrilintide-Semaglutide\"[tiab] OR \"CagriSema 2.4/2.4\"[tiab]",
      "query_terms": [
        "CagriSema",
        "Cagrilintide-Semaglutide",
        "CagriSema 2.4/2.4"
      ],
      "excluded_terms": [
        {
          "term": "amylin-GLP-1 combination",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 59,
      "total_in_window": 66,
      "name_only_total": 45,
      "synonym_contribution": 0.237,
      "applied_context_total": 42,
      "applied_context_share": 0.712,
      "first_year_in_window": 2022,
      "publications_2016_2020": 0,
      "publications_2021_2025": 43,
      "growth_ratio_5y": null,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 0,
        "2021": 0,
        "2022": 1,
        "2023": 4,
        "2024": 12,
        "2025": 26,
        "2026": 23
      }
    },
    {
      "slug": "ipamorelin",
      "name": "Ipamorelin",
      "category": "muscle",
      "url": "https://peptahub.com/peptides/ipamorelin",
      "query": "\"Ipamorelin\"[tiab] OR \"NNC 26-0161\"[tiab]",
      "query_terms": [
        "Ipamorelin",
        "NNC 26-0161"
      ],
      "excluded_terms": [],
      "total_all_years": 49,
      "total_in_window": 46,
      "name_only_total": 49,
      "synonym_contribution": 0,
      "applied_context_total": 33,
      "applied_context_share": 0.673,
      "first_year_in_window": 2000,
      "publications_2016_2020": 13,
      "publications_2021_2025": 2,
      "growth_ratio_5y": 0.15,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 1,
        "2001": 4,
        "2002": 2,
        "2003": 1,
        "2004": 2,
        "2005": 0,
        "2006": 1,
        "2007": 0,
        "2008": 0,
        "2009": 2,
        "2010": 0,
        "2011": 1,
        "2012": 3,
        "2013": 1,
        "2014": 2,
        "2015": 3,
        "2016": 4,
        "2017": 2,
        "2018": 4,
        "2019": 1,
        "2020": 2,
        "2021": 0,
        "2022": 0,
        "2023": 0,
        "2024": 2,
        "2025": 0,
        "2026": 8
      }
    },
    {
      "slug": "mazdutide",
      "name": "Mazdutide",
      "category": "weight-loss",
      "url": "https://peptahub.com/peptides/mazdutide",
      "query": "\"Mazdutide\"[tiab] OR \"IBI362\"[tiab] OR \"LY3305677\"[tiab] OR \"OXM-3\"[tiab] OR \"Xinermei\"[tiab]",
      "query_terms": [
        "Mazdutide",
        "IBI362",
        "LY3305677",
        "OXM-3",
        "Xinermei"
      ],
      "excluded_terms": [],
      "total_all_years": 49,
      "total_in_window": 55,
      "name_only_total": 44,
      "synonym_contribution": 0.102,
      "applied_context_total": 36,
      "applied_context_share": 0.735,
      "first_year_in_window": 2003,
      "publications_2016_2020": 1,
      "publications_2021_2025": 32,
      "growth_ratio_5y": 32,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 1,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 1,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 1,
        "2020": 0,
        "2021": 1,
        "2022": 2,
        "2023": 1,
        "2024": 8,
        "2025": 20,
        "2026": 20
      }
    },
    {
      "slug": "fibronectin-peptides",
      "name": "Fibronectin Peptides",
      "category": "recovery",
      "url": "https://peptahub.com/peptides/fibronectin-peptides",
      "query": "\"Fibronectin Peptides\"[tiab]",
      "query_terms": [
        "Fibronectin Peptides"
      ],
      "excluded_terms": [
        {
          "term": "FN peptides",
          "reason": "class-descriptor"
        },
        {
          "term": "RGD-fibronectin fragments",
          "reason": "class-descriptor"
        },
        {
          "term": "PHSRN peptides",
          "reason": "class-descriptor"
        },
        {
          "term": "Fibronectin-derived peptides",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 46,
      "total_in_window": 22,
      "name_only_total": 46,
      "synonym_contribution": 0,
      "applied_context_total": 16,
      "applied_context_share": 0.348,
      "first_year_in_window": 2000,
      "publications_2016_2020": 1,
      "publications_2021_2025": 3,
      "growth_ratio_5y": 3,
      "reliability": "low",
      "reliability_note": "The compound name is a short acronym or a family term, so title/abstract matching can capture unrelated records.",
      "by_year": {
        "2000": 2,
        "2001": 1,
        "2002": 3,
        "2003": 0,
        "2004": 1,
        "2005": 1,
        "2006": 0,
        "2007": 1,
        "2008": 1,
        "2009": 1,
        "2010": 1,
        "2011": 0,
        "2012": 2,
        "2013": 1,
        "2014": 2,
        "2015": 1,
        "2016": 0,
        "2017": 0,
        "2018": 1,
        "2019": 0,
        "2020": 0,
        "2021": 0,
        "2022": 0,
        "2023": 0,
        "2024": 1,
        "2025": 2,
        "2026": 0
      }
    },
    {
      "slug": "argireline",
      "name": "Argireline",
      "category": "skin",
      "url": "https://peptahub.com/peptides/argireline",
      "query": "\"Argireline\"[tiab] OR \"Acetyl Hexapeptide-8\"[tiab] OR \"Acetyl Hexapeptide-3\"[tiab]",
      "query_terms": [
        "Argireline",
        "Acetyl Hexapeptide-8",
        "Acetyl Hexapeptide-3"
      ],
      "excluded_terms": [
        {
          "term": "Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2",
          "reason": "residue-sequence"
        }
      ],
      "total_all_years": 45,
      "total_in_window": 52,
      "name_only_total": 21,
      "synonym_contribution": 0.533,
      "applied_context_total": 23,
      "applied_context_share": 0.511,
      "first_year_in_window": 2002,
      "publications_2016_2020": 7,
      "publications_2021_2025": 24,
      "growth_ratio_5y": 3.43,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 1,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 1,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 1,
        "2013": 4,
        "2014": 6,
        "2015": 2,
        "2016": 0,
        "2017": 1,
        "2018": 1,
        "2019": 1,
        "2020": 4,
        "2021": 6,
        "2022": 1,
        "2023": 3,
        "2024": 5,
        "2025": 9,
        "2026": 6
      }
    },
    {
      "slug": "igf-1-des",
      "name": "IGF-1 DES",
      "category": "muscle",
      "url": "https://peptahub.com/peptides/igf-1-des",
      "query": "\"IGF-1 DES\"[tiab] OR \"Des(1-3)IGF-1\"[tiab] OR \"des IGF-1\"[tiab] OR \"truncated IGF-1\"[tiab] OR \"IGF-1 DES(1-3)\"[tiab]",
      "query_terms": [
        "IGF-1 DES",
        "Des(1-3)IGF-1",
        "des IGF-1",
        "truncated IGF-1",
        "IGF-1 DES(1-3)"
      ],
      "excluded_terms": [],
      "total_all_years": 40,
      "total_in_window": 19,
      "name_only_total": 6,
      "synonym_contribution": 0.85,
      "applied_context_total": 8,
      "applied_context_share": 0.2,
      "first_year_in_window": 2000,
      "publications_2016_2020": 1,
      "publications_2021_2025": 0,
      "growth_ratio_5y": 0,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 2,
        "2001": 2,
        "2002": 1,
        "2003": 2,
        "2004": 1,
        "2005": 1,
        "2006": 0,
        "2007": 1,
        "2008": 3,
        "2009": 0,
        "2010": 1,
        "2011": 1,
        "2012": 0,
        "2013": 2,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 1,
        "2021": 0,
        "2022": 0,
        "2023": 0,
        "2024": 0,
        "2025": 0,
        "2026": 1
      }
    },
    {
      "slug": "adamax",
      "name": "Adamax",
      "category": "cognitive",
      "url": "https://peptahub.com/peptides/adamax",
      "query": "\"Adamax\"[tiab] OR \"Ac-MEHFPGP-AG-NH2\"[tiab] OR \"Adamantyl Semax\"[tiab] OR \"N-Acetyl Semax Adamantyl\"[tiab]",
      "query_terms": [
        "Adamax",
        "Ac-MEHFPGP-AG-NH2",
        "Adamantyl Semax",
        "N-Acetyl Semax Adamantyl"
      ],
      "excluded_terms": [],
      "total_all_years": 39,
      "total_in_window": 42,
      "name_only_total": 39,
      "synonym_contribution": 0,
      "applied_context_total": 7,
      "applied_context_share": 0.179,
      "first_year_in_window": 2019,
      "publications_2016_2020": 4,
      "publications_2021_2025": 31,
      "growth_ratio_5y": 7.75,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 1,
        "2020": 3,
        "2021": 1,
        "2022": 4,
        "2023": 7,
        "2024": 7,
        "2025": 12,
        "2026": 7
      }
    },
    {
      "slug": "semax-4-7",
      "name": "Semax 4-7",
      "category": "cognitive",
      "url": "https://peptahub.com/peptides/semax-4-7",
      "query": "\"Semax 4-7\"[tiab] OR \"ACTH(4-7)\"[tiab] OR \"ACTH 4-7\"[tiab] OR \"ACTH fragment 4-7\"[tiab]",
      "query_terms": [
        "Semax 4-7",
        "ACTH(4-7)",
        "ACTH 4-7",
        "ACTH fragment 4-7"
      ],
      "excluded_terms": [
        {
          "term": "Met-Glu-His-Phe",
          "reason": "residue-sequence"
        }
      ],
      "total_all_years": 37,
      "total_in_window": 27,
      "name_only_total": 0,
      "synonym_contribution": 1,
      "applied_context_total": 28,
      "applied_context_share": 0.757,
      "first_year_in_window": 2000,
      "publications_2016_2020": 4,
      "publications_2021_2025": 13,
      "growth_ratio_5y": 3.25,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 1,
        "2001": 1,
        "2002": 0,
        "2003": 0,
        "2004": 1,
        "2005": 0,
        "2006": 1,
        "2007": 1,
        "2008": 1,
        "2009": 2,
        "2010": 1,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 1,
        "2016": 0,
        "2017": 1,
        "2018": 0,
        "2019": 0,
        "2020": 3,
        "2021": 5,
        "2022": 0,
        "2023": 2,
        "2024": 4,
        "2025": 2,
        "2026": 0
      }
    },
    {
      "slug": "cjc-1295",
      "name": "CJC-1295",
      "category": "muscle",
      "url": "https://peptahub.com/peptides/cjc-1295",
      "query": "\"CJC-1295\"[tiab] OR \"Modified GRF 1-29\"[tiab] OR \"Mod GRF\"[tiab] OR \"CJC-1295 no DAC\"[tiab]",
      "query_terms": [
        "CJC-1295",
        "Modified GRF 1-29",
        "Mod GRF",
        "CJC-1295 no DAC"
      ],
      "excluded_terms": [],
      "total_all_years": 33,
      "total_in_window": 39,
      "name_only_total": 32,
      "synonym_contribution": 0.03,
      "applied_context_total": 18,
      "applied_context_share": 0.545,
      "first_year_in_window": 2005,
      "publications_2016_2020": 9,
      "publications_2021_2025": 8,
      "growth_ratio_5y": 0.89,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 2,
        "2006": 3,
        "2007": 0,
        "2008": 0,
        "2009": 2,
        "2010": 1,
        "2011": 1,
        "2012": 1,
        "2013": 1,
        "2014": 1,
        "2015": 1,
        "2016": 3,
        "2017": 0,
        "2018": 2,
        "2019": 3,
        "2020": 1,
        "2021": 2,
        "2022": 3,
        "2023": 1,
        "2024": 1,
        "2025": 1,
        "2026": 9
      }
    },
    {
      "slug": "matrixyl",
      "name": "Matrixyl",
      "category": "skin",
      "url": "https://peptahub.com/peptides/matrixyl",
      "query": "\"Matrixyl\"[tiab] OR \"Palmitoyl Pentapeptide-4\"[tiab] OR \"Pal-KTTKS\"[tiab] OR \"Palmitoyl Pentapeptide-3\"[tiab]",
      "query_terms": [
        "Matrixyl",
        "Palmitoyl Pentapeptide-4",
        "Pal-KTTKS",
        "Palmitoyl Pentapeptide-3"
      ],
      "excluded_terms": [],
      "total_all_years": 30,
      "total_in_window": 32,
      "name_only_total": 12,
      "synonym_contribution": 0.6,
      "applied_context_total": 10,
      "applied_context_share": 0.333,
      "first_year_in_window": 2004,
      "publications_2016_2020": 8,
      "publications_2021_2025": 12,
      "growth_ratio_5y": 1.5,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 1,
        "2005": 1,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 3,
        "2010": 0,
        "2011": 0,
        "2012": 1,
        "2013": 2,
        "2014": 2,
        "2015": 0,
        "2016": 0,
        "2017": 1,
        "2018": 0,
        "2019": 6,
        "2020": 1,
        "2021": 2,
        "2022": 2,
        "2023": 1,
        "2024": 4,
        "2025": 3,
        "2026": 2
      }
    },
    {
      "slug": "leuphasyl",
      "name": "Leuphasyl",
      "category": "skin",
      "url": "https://peptahub.com/peptides/leuphasyl",
      "query": "\"Leuphasyl\"[tiab] OR \"Pentapeptide-18\"[tiab] OR \"YAGFL peptide\"[tiab] OR \"Tyr-D-Ala-Gly-Phe-Leu\"[tiab]",
      "query_terms": [
        "Leuphasyl",
        "Pentapeptide-18",
        "YAGFL peptide",
        "Tyr-D-Ala-Gly-Phe-Leu"
      ],
      "excluded_terms": [],
      "total_all_years": 29,
      "total_in_window": 12,
      "name_only_total": 3,
      "synonym_contribution": 0.897,
      "applied_context_total": 9,
      "applied_context_share": 0.31,
      "first_year_in_window": 2000,
      "publications_2016_2020": 2,
      "publications_2021_2025": 2,
      "growth_ratio_5y": 1,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 1,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 3,
        "2006": 1,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 1,
        "2020": 1,
        "2021": 0,
        "2022": 0,
        "2023": 0,
        "2024": 2,
        "2025": 0,
        "2026": 3
      }
    },
    {
      "slug": "palmitoyl-tetrapeptide-7",
      "name": "Palmitoyl Tetrapeptide-7",
      "category": "skin",
      "url": "https://peptahub.com/peptides/palmitoyl-tetrapeptide-7",
      "query": "\"Palmitoyl Tetrapeptide-7\"[tiab] OR \"Pal-GQPR\"[tiab] OR \"Rigin\"[tiab]",
      "query_terms": [
        "Palmitoyl Tetrapeptide-7",
        "Pal-GQPR",
        "Rigin"
      ],
      "excluded_terms": [
        {
          "term": "Palmitoyl-Gly-Gln-Pro-Arg",
          "reason": "residue-sequence"
        }
      ],
      "total_all_years": 29,
      "total_in_window": 20,
      "name_only_total": 0,
      "synonym_contribution": 1,
      "applied_context_total": 7,
      "applied_context_share": 0.241,
      "first_year_in_window": 2000,
      "publications_2016_2020": 5,
      "publications_2021_2025": 6,
      "growth_ratio_5y": 1.2,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 1,
        "2001": 1,
        "2002": 1,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 1,
        "2011": 0,
        "2012": 0,
        "2013": 2,
        "2014": 2,
        "2015": 1,
        "2016": 1,
        "2017": 2,
        "2018": 1,
        "2019": 0,
        "2020": 1,
        "2021": 0,
        "2022": 1,
        "2023": 2,
        "2024": 1,
        "2025": 2,
        "2026": 0
      }
    },
    {
      "slug": "follistatin-315",
      "name": "Follistatin-315",
      "category": "muscle",
      "url": "https://peptahub.com/peptides/follistatin-315",
      "query": "\"Follistatin-315\"[tiab] OR \"FST-315\"[tiab] OR \"FS-315\"[tiab] OR \"Follistatin isoform 315\"[tiab]",
      "query_terms": [
        "Follistatin-315",
        "FST-315",
        "FS-315",
        "Follistatin isoform 315"
      ],
      "excluded_terms": [],
      "total_all_years": 26,
      "total_in_window": 20,
      "name_only_total": 14,
      "synonym_contribution": 0.462,
      "applied_context_total": 7,
      "applied_context_share": 0.269,
      "first_year_in_window": 2000,
      "publications_2016_2020": 5,
      "publications_2021_2025": 1,
      "growth_ratio_5y": 0.2,
      "reliability": "high",
      "reliability_note": "Distinctive name; counts should closely match a manual PubMed search.",
      "by_year": {
        "2000": 2,
        "2001": 2,
        "2002": 0,
        "2003": 1,
        "2004": 0,
        "2005": 2,
        "2006": 0,
        "2007": 0,
        "2008": 1,
        "2009": 0,
        "2010": 1,
        "2011": 0,
        "2012": 1,
        "2013": 2,
        "2014": 0,
        "2015": 2,
        "2016": 1,
        "2017": 1,
        "2018": 1,
        "2019": 2,
        "2020": 0,
        "2021": 1,
        "2022": 0,
        "2023": 0,
        "2024": 0,
        "2025": 0,
        "2026": 0
      }
    },
    {
      "slug": "igf-1-lr3",
      "name": "IGF-1 LR3",
      "category": "muscle",
      "url": "https://peptahub.com/peptides/igf-1-lr3",
      "query": "\"IGF-1 LR3\"[tiab] OR \"Long R3 IGF-1\"[tiab] OR \"Insulin-like Growth Factor-1 LR3\"[tiab] OR \"IGF1-LR3\"[tiab] OR \"LR3-IGF-1\"[tiab]",
      "query_terms": [
        "IGF-1 LR3",
        "Long R3 IGF-1",
        "Insulin-like Growth Factor-1 LR3",
        "IGF1-LR3",
        "LR3-IGF-1"
      ],
      "excluded_terms": [],
      "total_all_years": 24,
      "total_in_window": 24,
      "name_only_total": 11,
      "synonym_contribution": 0.542,
      "applied_context_total": 16,
      "applied_context_share": 0.667,
      "first_year_in_window": 2002,
      "publications_2016_2020": 1,
      "publications_2021_2025": 12,
      "growth_ratio_5y": 12,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 1,
        "2003": 3,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 1,
        "2008": 0,
        "2009": 1,
        "2010": 0,
        "2011": 1,
        "2012": 1,
        "2013": 0,
        "2014": 1,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 1,
        "2021": 2,
        "2022": 2,
        "2023": 2,
        "2024": 2,
        "2025": 4,
        "2026": 2
      }
    },
    {
      "slug": "ovagen",
      "name": "Ovagen",
      "category": "longevity",
      "url": "https://peptahub.com/peptides/ovagen",
      "query": "\"Ovagen\"[tiab] OR \"EDL tripeptide\"[tiab]",
      "query_terms": [
        "Ovagen",
        "EDL tripeptide"
      ],
      "excluded_terms": [
        {
          "term": "Glu-Asp-Leu",
          "reason": "residue-sequence"
        },
        {
          "term": "liver bioregulator",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 22,
      "total_in_window": 19,
      "name_only_total": 22,
      "synonym_contribution": 0,
      "applied_context_total": 16,
      "applied_context_share": 0.727,
      "first_year_in_window": 2000,
      "publications_2016_2020": 0,
      "publications_2021_2025": 0,
      "growth_ratio_5y": null,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 1,
        "2001": 1,
        "2002": 3,
        "2003": 2,
        "2004": 1,
        "2005": 1,
        "2006": 3,
        "2007": 2,
        "2008": 2,
        "2009": 1,
        "2010": 2,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 0,
        "2021": 0,
        "2022": 0,
        "2023": 0,
        "2024": 0,
        "2025": 0,
        "2026": 0
      }
    },
    {
      "slug": "retinalamin",
      "name": "Retinalamin",
      "category": "other",
      "url": "https://peptahub.com/peptides/retinalamin",
      "query": "\"Retinalamin\"[tiab]",
      "query_terms": [
        "Retinalamin"
      ],
      "excluded_terms": [
        {
          "term": "retina polypeptide complex",
          "reason": "class-descriptor"
        },
        {
          "term": "retinal bioregulator",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 20,
      "total_in_window": 20,
      "name_only_total": 20,
      "synonym_contribution": 0,
      "applied_context_total": 16,
      "applied_context_share": 0.8,
      "first_year_in_window": 2002,
      "publications_2016_2020": 7,
      "publications_2021_2025": 6,
      "growth_ratio_5y": 0.86,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 1,
        "2003": 1,
        "2004": 0,
        "2005": 1,
        "2006": 1,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 1,
        "2012": 0,
        "2013": 1,
        "2014": 1,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 2,
        "2019": 3,
        "2020": 2,
        "2021": 3,
        "2022": 0,
        "2023": 0,
        "2024": 2,
        "2025": 1,
        "2026": 0
      }
    },
    {
      "slug": "foxo4-dri",
      "name": "FOXO4-DRI",
      "category": "longevity",
      "url": "https://peptahub.com/peptides/foxo4-dri",
      "query": "\"FOXO4-DRI\"[tiab] OR \"FOXO4-D-Retro-Inverso\"[tiab] OR \"FOXO4 DRI\"[tiab] OR \"Senolytic Peptide FOXO4\"[tiab]",
      "query_terms": [
        "FOXO4-DRI",
        "FOXO4-D-Retro-Inverso",
        "FOXO4 DRI",
        "Senolytic Peptide FOXO4"
      ],
      "excluded_terms": [],
      "total_all_years": 18,
      "total_in_window": 21,
      "name_only_total": 18,
      "synonym_contribution": 0,
      "applied_context_total": 10,
      "applied_context_share": 0.556,
      "first_year_in_window": 2017,
      "publications_2016_2020": 6,
      "publications_2021_2025": 12,
      "growth_ratio_5y": 2,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 3,
        "2018": 2,
        "2019": 0,
        "2020": 1,
        "2021": 2,
        "2022": 3,
        "2023": 2,
        "2024": 2,
        "2025": 3,
        "2026": 3
      }
    },
    {
      "slug": "dihexa",
      "name": "Dihexa",
      "category": "cognitive",
      "url": "https://peptahub.com/peptides/dihexa",
      "query": "\"Dihexa\"[tiab] OR \"N-hexanoic-Tyr-Ile-(6) aminohexanoic amide\"[tiab]",
      "query_terms": [
        "Dihexa",
        "N-hexanoic-Tyr-Ile-(6) aminohexanoic amide"
      ],
      "excluded_terms": [],
      "total_all_years": 17,
      "total_in_window": 18,
      "name_only_total": 17,
      "synonym_contribution": 0,
      "applied_context_total": 9,
      "applied_context_share": 0.529,
      "first_year_in_window": 2005,
      "publications_2016_2020": 2,
      "publications_2021_2025": 4,
      "growth_ratio_5y": 2,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 1,
        "2006": 0,
        "2007": 1,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 1,
        "2013": 1,
        "2014": 4,
        "2015": 3,
        "2016": 1,
        "2017": 0,
        "2018": 1,
        "2019": 0,
        "2020": 0,
        "2021": 2,
        "2022": 1,
        "2023": 0,
        "2024": 1,
        "2025": 0,
        "2026": 1
      }
    },
    {
      "slug": "alarelin",
      "name": "Alarelin",
      "category": "other",
      "url": "https://peptahub.com/peptides/alarelin",
      "query": "\"Alarelin\"[tiab] OR \"alarelin acetate\"[tiab]",
      "query_terms": [
        "Alarelin",
        "alarelin acetate"
      ],
      "excluded_terms": [
        {
          "term": "GnRH agonist alarelin",
          "reason": "class-descriptor"
        },
        {
          "term": "LH-RH agonist",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 16,
      "total_in_window": 16,
      "name_only_total": 16,
      "synonym_contribution": 0,
      "applied_context_total": 8,
      "applied_context_share": 0.5,
      "first_year_in_window": 2004,
      "publications_2016_2020": 4,
      "publications_2021_2025": 3,
      "growth_ratio_5y": 0.75,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 1,
        "2005": 1,
        "2006": 1,
        "2007": 0,
        "2008": 1,
        "2009": 2,
        "2010": 1,
        "2011": 0,
        "2012": 0,
        "2013": 1,
        "2014": 1,
        "2015": 0,
        "2016": 1,
        "2017": 0,
        "2018": 0,
        "2019": 1,
        "2020": 2,
        "2021": 1,
        "2022": 0,
        "2023": 0,
        "2024": 1,
        "2025": 1,
        "2026": 0
      }
    },
    {
      "slug": "pinealon",
      "name": "Pinealon",
      "category": "cognitive",
      "url": "https://peptahub.com/peptides/pinealon",
      "query": "\"Pinealon\"[tiab] OR \"EDR tripeptide\"[tiab] OR \"Epithalamin peptide fragment\"[tiab]",
      "query_terms": [
        "Pinealon",
        "EDR tripeptide",
        "Epithalamin peptide fragment"
      ],
      "excluded_terms": [
        {
          "term": "Glu-Asp-Arg",
          "reason": "residue-sequence"
        }
      ],
      "total_all_years": 15,
      "total_in_window": 15,
      "name_only_total": 15,
      "synonym_contribution": 0,
      "applied_context_total": 3,
      "applied_context_share": 0.2,
      "first_year_in_window": 2008,
      "publications_2016_2020": 1,
      "publications_2021_2025": 0,
      "growth_ratio_5y": 0,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 2,
        "2009": 0,
        "2010": 0,
        "2011": 3,
        "2012": 3,
        "2013": 2,
        "2014": 1,
        "2015": 2,
        "2016": 1,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 0,
        "2021": 0,
        "2022": 0,
        "2023": 0,
        "2024": 0,
        "2025": 0,
        "2026": 1
      }
    },
    {
      "slug": "cortagen",
      "name": "Cortagen",
      "category": "cognitive",
      "url": "https://peptahub.com/peptides/cortagen",
      "query": "\"Cortagen\"[tiab] OR \"AEDP tetrapeptide\"[tiab] OR \"Cortagen bioregulator\"[tiab]",
      "query_terms": [
        "Cortagen",
        "AEDP tetrapeptide",
        "Cortagen bioregulator"
      ],
      "excluded_terms": [
        {
          "term": "Ala-Glu-Asp-Pro",
          "reason": "residue-sequence"
        }
      ],
      "total_all_years": 13,
      "total_in_window": 13,
      "name_only_total": 13,
      "synonym_contribution": 0,
      "applied_context_total": 6,
      "applied_context_share": 0.462,
      "first_year_in_window": 2000,
      "publications_2016_2020": 0,
      "publications_2021_2025": 1,
      "growth_ratio_5y": null,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 1,
        "2001": 1,
        "2002": 4,
        "2003": 0,
        "2004": 2,
        "2005": 1,
        "2006": 1,
        "2007": 1,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 1,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 0,
        "2021": 0,
        "2022": 0,
        "2023": 1,
        "2024": 0,
        "2025": 0,
        "2026": 0
      }
    },
    {
      "slug": "follistatin-344",
      "name": "Follistatin-344",
      "category": "muscle",
      "url": "https://peptahub.com/peptides/follistatin-344",
      "query": "\"Follistatin-344\"[tiab] OR \"FST-344\"[tiab] OR \"FS-344\"[tiab] OR \"Follistatin 344\"[tiab] OR \"FST344\"[tiab]",
      "query_terms": [
        "Follistatin-344",
        "FST-344",
        "FS-344",
        "Follistatin 344",
        "FST344"
      ],
      "excluded_terms": [],
      "total_all_years": 12,
      "total_in_window": 9,
      "name_only_total": 5,
      "synonym_contribution": 0.583,
      "applied_context_total": 4,
      "applied_context_share": 0.333,
      "first_year_in_window": 2016,
      "publications_2016_2020": 7,
      "publications_2021_2025": 0,
      "growth_ratio_5y": 0,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 1,
        "2017": 1,
        "2018": 0,
        "2019": 1,
        "2020": 4,
        "2021": 0,
        "2022": 0,
        "2023": 0,
        "2024": 0,
        "2025": 0,
        "2026": 2
      }
    },
    {
      "slug": "aod-9604",
      "name": "AOD-9604",
      "category": "weight-loss",
      "url": "https://peptahub.com/peptides/aod-9604",
      "query": "\"AOD-9604\"[tiab] OR \"Anti-Obesity Drug 9604\"[tiab] OR \"hGH Fragment 177-191\"[tiab]",
      "query_terms": [
        "AOD-9604",
        "Anti-Obesity Drug 9604",
        "hGH Fragment 177-191"
      ],
      "excluded_terms": [],
      "total_all_years": 11,
      "total_in_window": 12,
      "name_only_total": 11,
      "synonym_contribution": 0,
      "applied_context_total": 2,
      "applied_context_share": 0.182,
      "first_year_in_window": 2003,
      "publications_2016_2020": 1,
      "publications_2021_2025": 0,
      "growth_ratio_5y": 0,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 2,
        "2004": 1,
        "2005": 1,
        "2006": 1,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 1,
        "2014": 2,
        "2015": 1,
        "2016": 1,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 0,
        "2021": 0,
        "2022": 0,
        "2023": 0,
        "2024": 0,
        "2025": 0,
        "2026": 2
      }
    },
    {
      "slug": "palmitoyl-tripeptide-38",
      "name": "Palmitoyl Tripeptide-38",
      "category": "skin",
      "url": "https://peptahub.com/peptides/palmitoyl-tripeptide-38",
      "query": "\"Palmitoyl Tripeptide-38\"[tiab] OR \"MATRIXYL synthe'6\"[tiab] OR \"Pal-KMO2K\"[tiab] OR \"Volulip\"[tiab] OR \"PT-38\"[tiab]",
      "query_terms": [
        "Palmitoyl Tripeptide-38",
        "MATRIXYL synthe'6",
        "Pal-KMO2K",
        "Volulip",
        "PT-38"
      ],
      "excluded_terms": [],
      "total_all_years": 8,
      "total_in_window": 9,
      "name_only_total": 3,
      "synonym_contribution": 0.625,
      "applied_context_total": 3,
      "applied_context_share": 0.375,
      "first_year_in_window": 2015,
      "publications_2016_2020": 5,
      "publications_2021_2025": 2,
      "growth_ratio_5y": 0.4,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 2,
        "2016": 2,
        "2017": 0,
        "2018": 1,
        "2019": 0,
        "2020": 2,
        "2021": 0,
        "2022": 1,
        "2023": 1,
        "2024": 0,
        "2025": 0,
        "2026": 0
      }
    },
    {
      "slug": "palmitoyl-tripeptide-5",
      "name": "Palmitoyl Tripeptide-5",
      "category": "skin",
      "url": "https://peptahub.com/peptides/palmitoyl-tripeptide-5",
      "query": "\"Palmitoyl Tripeptide-5\"[tiab] OR \"SYN-COLL\"[tiab] OR \"Pal-KVK\"[tiab] OR \"SYR tripeptide\"[tiab]",
      "query_terms": [
        "Palmitoyl Tripeptide-5",
        "SYN-COLL",
        "Pal-KVK",
        "SYR tripeptide"
      ],
      "excluded_terms": [
        {
          "term": "Pal-Lys-Val-Lys",
          "reason": "residue-sequence"
        }
      ],
      "total_all_years": 5,
      "total_in_window": 8,
      "name_only_total": 4,
      "synonym_contribution": 0.2,
      "applied_context_total": 1,
      "applied_context_share": 0.2,
      "first_year_in_window": 2019,
      "publications_2016_2020": 2,
      "publications_2021_2025": 5,
      "growth_ratio_5y": 2.5,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 1,
        "2020": 1,
        "2021": 1,
        "2022": 0,
        "2023": 1,
        "2024": 1,
        "2025": 2,
        "2026": 1
      }
    },
    {
      "slug": "epitide",
      "name": "Epitide",
      "category": "skin",
      "url": "https://peptahub.com/peptides/epitide",
      "query": "\"Epitide\"[tiab] OR \"Palmitoyl Tripeptide-38\"[tiab] OR \"MATRIXYL synthe'6\"[tiab] OR \"Volulip\"[tiab] OR \"Pal-KMO2K\"[tiab]",
      "query_terms": [
        "Epitide",
        "Palmitoyl Tripeptide-38",
        "MATRIXYL synthe'6",
        "Volulip",
        "Pal-KMO2K"
      ],
      "excluded_terms": [],
      "total_all_years": 4,
      "total_in_window": 5,
      "name_only_total": 1,
      "synonym_contribution": 0.75,
      "applied_context_total": 2,
      "applied_context_share": 0.5,
      "first_year_in_window": 2015,
      "publications_2016_2020": 2,
      "publications_2021_2025": 1,
      "growth_ratio_5y": 0.5,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 2,
        "2016": 1,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 1,
        "2021": 0,
        "2022": 0,
        "2023": 0,
        "2024": 1,
        "2025": 0,
        "2026": 0
      }
    },
    {
      "slug": "palmitoyl-tripeptide-1",
      "name": "Palmitoyl Tripeptide-1",
      "category": "skin",
      "url": "https://peptahub.com/peptides/palmitoyl-tripeptide-1",
      "query": "\"Palmitoyl Tripeptide-1\"[tiab] OR \"Pal-GHK\"[tiab] OR \"Biopeptide CL\"[tiab]",
      "query_terms": [
        "Palmitoyl Tripeptide-1",
        "Pal-GHK",
        "Biopeptide CL"
      ],
      "excluded_terms": [
        {
          "term": "Palmitoyl-Gly-His-Lys",
          "reason": "residue-sequence"
        },
        {
          "term": "Palmitoyl Oligopeptide",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 4,
      "total_in_window": 6,
      "name_only_total": 1,
      "synonym_contribution": 0.75,
      "applied_context_total": 1,
      "applied_context_share": 0.25,
      "first_year_in_window": 2009,
      "publications_2016_2020": 0,
      "publications_2021_2025": 4,
      "growth_ratio_5y": null,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 1,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 0,
        "2021": 0,
        "2022": 0,
        "2023": 0,
        "2024": 2,
        "2025": 2,
        "2026": 1
      }
    },
    {
      "slug": "ptd-dbm",
      "name": "PTD-DBM",
      "category": "skin",
      "url": "https://peptahub.com/peptides/ptd-dbm",
      "query": "\"PTD-DBM\"[tiab] OR \"PTD-DBM peptide\"[tiab] OR \"CXXC5-Dvl inhibitor peptide\"[tiab]",
      "query_terms": [
        "PTD-DBM",
        "PTD-DBM peptide",
        "CXXC5-Dvl inhibitor peptide"
      ],
      "excluded_terms": [],
      "total_all_years": 4,
      "total_in_window": 4,
      "name_only_total": 4,
      "synonym_contribution": 0,
      "applied_context_total": 4,
      "applied_context_share": 1,
      "first_year_in_window": 2015,
      "publications_2016_2020": 0,
      "publications_2021_2025": 3,
      "growth_ratio_5y": null,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 1,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 0,
        "2021": 0,
        "2022": 0,
        "2023": 2,
        "2024": 0,
        "2025": 1,
        "2026": 0
      }
    },
    {
      "slug": "thymosin-beta-4-sulfoxide",
      "name": "Thymosin Beta-4 Sulfoxide",
      "category": "recovery",
      "url": "https://peptahub.com/peptides/thymosin-beta-4-sulfoxide",
      "query": "\"Thymosin Beta-4 Sulfoxide\"[tiab] OR \"TB-4 Sulfoxide\"[tiab] OR \"Tβ4-SO\"[tiab] OR \"Tβ4-sulfoxide\"[tiab] OR \"oxidized TB-500\"[tiab]",
      "query_terms": [
        "Thymosin Beta-4 Sulfoxide",
        "TB-4 Sulfoxide",
        "Tβ4-SO",
        "Tβ4-sulfoxide",
        "oxidized TB-500"
      ],
      "excluded_terms": [],
      "total_all_years": 4,
      "total_in_window": 2,
      "name_only_total": 3,
      "synonym_contribution": 0.25,
      "applied_context_total": 1,
      "applied_context_share": 0.25,
      "first_year_in_window": 2007,
      "publications_2016_2020": 1,
      "publications_2021_2025": 0,
      "growth_ratio_5y": 0,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 1,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 1,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 0,
        "2021": 0,
        "2022": 0,
        "2023": 0,
        "2024": 0,
        "2025": 0,
        "2026": 0
      }
    },
    {
      "slug": "testagen",
      "name": "Testagen",
      "category": "sexual-health",
      "url": "https://peptahub.com/peptides/testagen",
      "query": "\"Testagen\"[tiab] OR \"KEDG tetrapeptide\"[tiab]",
      "query_terms": [
        "Testagen",
        "KEDG tetrapeptide"
      ],
      "excluded_terms": [
        {
          "term": "Lys-Glu-Asp-Gly",
          "reason": "residue-sequence"
        },
        {
          "term": "testes bioregulator",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 2,
      "total_in_window": 2,
      "name_only_total": 2,
      "synonym_contribution": 0,
      "applied_context_total": 0,
      "applied_context_share": 0,
      "first_year_in_window": 2011,
      "publications_2016_2020": 0,
      "publications_2021_2025": 1,
      "growth_ratio_5y": null,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 1,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 0,
        "2021": 0,
        "2022": 0,
        "2023": 0,
        "2024": 0,
        "2025": 1,
        "2026": 0
      }
    },
    {
      "slug": "chonluten",
      "name": "Chonluten",
      "category": "immune",
      "url": "https://peptahub.com/peptides/chonluten",
      "query": "\"Chonluten\"[tiab] OR \"KED tripeptide\"[tiab]",
      "query_terms": [
        "Chonluten",
        "KED tripeptide"
      ],
      "excluded_terms": [
        {
          "term": "Glu-Asp-Gly",
          "reason": "residue-sequence"
        },
        {
          "term": "lung bioregulator",
          "reason": "class-descriptor"
        },
        {
          "term": "bronchi peptide",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 1,
      "total_in_window": 1,
      "name_only_total": 1,
      "synonym_contribution": 0,
      "applied_context_total": 0,
      "applied_context_share": 0,
      "first_year_in_window": 2022,
      "publications_2016_2020": 0,
      "publications_2021_2025": 1,
      "growth_ratio_5y": null,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 0,
        "2021": 0,
        "2022": 1,
        "2023": 0,
        "2024": 0,
        "2025": 0,
        "2026": 0
      }
    },
    {
      "slug": "heptapeptide-7",
      "name": "Heptapeptide-7",
      "category": "skin",
      "url": "https://peptahub.com/peptides/heptapeptide-7",
      "query": "\"Heptapeptide-7\"[tiab] OR \"Gransome Heptapeptide-7\"[tiab] OR \"Acetyl Tetrapeptide-2 related\"[tiab]",
      "query_terms": [
        "Heptapeptide-7",
        "Gransome Heptapeptide-7",
        "Acetyl Tetrapeptide-2 related"
      ],
      "excluded_terms": [
        {
          "term": "HP-7",
          "reason": "too-short"
        }
      ],
      "total_all_years": 1,
      "total_in_window": 1,
      "name_only_total": 1,
      "synonym_contribution": 0,
      "applied_context_total": 0,
      "applied_context_share": 0,
      "first_year_in_window": 2010,
      "publications_2016_2020": 0,
      "publications_2021_2025": 0,
      "growth_ratio_5y": null,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 1,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 0,
        "2021": 0,
        "2022": 0,
        "2023": 0,
        "2024": 0,
        "2025": 0,
        "2026": 0
      }
    },
    {
      "slug": "mod-grf-1-29",
      "name": "Mod GRF 1-29",
      "category": "muscle",
      "url": "https://peptahub.com/peptides/mod-grf-1-29",
      "query": "\"Mod GRF 1-29\"[tiab] OR \"Modified GRF 1-29\"[tiab] OR \"CJC-1295 without DAC\"[tiab] OR \"CJC-1295 no DAC\"[tiab] OR \"Tetrasubstituted GRF 1-29\"[tiab]",
      "query_terms": [
        "Mod GRF 1-29",
        "Modified GRF 1-29",
        "CJC-1295 without DAC",
        "CJC-1295 no DAC",
        "Tetrasubstituted GRF 1-29"
      ],
      "excluded_terms": [],
      "total_all_years": 1,
      "total_in_window": 2,
      "name_only_total": 0,
      "synonym_contribution": 1,
      "applied_context_total": 0,
      "applied_context_share": 0,
      "first_year_in_window": 2018,
      "publications_2016_2020": 2,
      "publications_2021_2025": 0,
      "growth_ratio_5y": 0,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 1,
        "2019": 1,
        "2020": 0,
        "2021": 0,
        "2022": 0,
        "2023": 0,
        "2024": 0,
        "2025": 0,
        "2026": 0
      }
    },
    {
      "slug": "palmitoyl-hexapeptide-12",
      "name": "Palmitoyl Hexapeptide-12",
      "category": "skin",
      "url": "https://peptahub.com/peptides/palmitoyl-hexapeptide-12",
      "query": "\"Palmitoyl Hexapeptide-12\"[tiab] OR \"Biopeptide EL\"[tiab] OR \"Pal-VGVAPG\"[tiab]",
      "query_terms": [
        "Palmitoyl Hexapeptide-12",
        "Biopeptide EL",
        "Pal-VGVAPG"
      ],
      "excluded_terms": [
        {
          "term": "Palmitoyl-Val-Gly-Val-Ala-Pro-Gly",
          "reason": "residue-sequence"
        }
      ],
      "total_all_years": 1,
      "total_in_window": 1,
      "name_only_total": 1,
      "synonym_contribution": 0,
      "applied_context_total": 0,
      "applied_context_share": 0,
      "first_year_in_window": 2025,
      "publications_2016_2020": 0,
      "publications_2021_2025": 1,
      "growth_ratio_5y": null,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 0,
        "2021": 0,
        "2022": 0,
        "2023": 0,
        "2024": 0,
        "2025": 1,
        "2026": 0
      }
    },
    {
      "slug": "peg-mgf",
      "name": "PEG-MGF",
      "category": "muscle",
      "url": "https://peptahub.com/peptides/peg-mgf",
      "query": "\"PEG-MGF\"[tiab] OR \"PEGylated MGF\"[tiab] OR \"PEGylated Mechano Growth Factor\"[tiab] OR \"IGF-1 Ec PEGylated\"[tiab]",
      "query_terms": [
        "PEG-MGF",
        "PEGylated MGF",
        "PEGylated Mechano Growth Factor",
        "IGF-1 Ec PEGylated"
      ],
      "excluded_terms": [],
      "total_all_years": 1,
      "total_in_window": 1,
      "name_only_total": 1,
      "synonym_contribution": 0,
      "applied_context_total": 1,
      "applied_context_share": 1,
      "first_year_in_window": 2026,
      "publications_2016_2020": 0,
      "publications_2021_2025": 0,
      "growth_ratio_5y": null,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 0,
        "2021": 0,
        "2022": 0,
        "2023": 0,
        "2024": 0,
        "2025": 0,
        "2026": 1
      }
    },
    {
      "slug": "syn-ake",
      "name": "SYN-AKE",
      "category": "skin",
      "url": "https://peptahub.com/peptides/syn-ake",
      "query": "\"SYN-AKE\"[tiab] OR \"Dipeptide Diaminobutyroyl Benzylamide Diacetate\"[tiab] OR \"Waglerin-1 analog\"[tiab]",
      "query_terms": [
        "SYN-AKE",
        "Dipeptide Diaminobutyroyl Benzylamide Diacetate",
        "Waglerin-1 analog"
      ],
      "excluded_terms": [],
      "total_all_years": 1,
      "total_in_window": 2,
      "name_only_total": 1,
      "synonym_contribution": 0,
      "applied_context_total": 0,
      "applied_context_share": 0,
      "first_year_in_window": 2023,
      "publications_2016_2020": 0,
      "publications_2021_2025": 2,
      "growth_ratio_5y": null,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 0,
        "2021": 0,
        "2022": 0,
        "2023": 1,
        "2024": 1,
        "2025": 0,
        "2026": 0
      }
    },
    {
      "slug": "vk2735",
      "name": "VK2735",
      "category": "weight-loss",
      "url": "https://peptahub.com/peptides/vk2735",
      "query": "\"VK2735\"[tiab] OR \"VK-2735\"[tiab]",
      "query_terms": [
        "VK2735",
        "VK-2735"
      ],
      "excluded_terms": [],
      "total_all_years": 1,
      "total_in_window": 1,
      "name_only_total": 1,
      "synonym_contribution": 0,
      "applied_context_total": 1,
      "applied_context_share": 1,
      "first_year_in_window": 2026,
      "publications_2016_2020": 0,
      "publications_2021_2025": 0,
      "growth_ratio_5y": null,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 0,
        "2021": 0,
        "2022": 0,
        "2023": 0,
        "2024": 0,
        "2025": 0,
        "2026": 1
      }
    },
    {
      "slug": "n-acetyl-semax",
      "name": "N-Acetyl Semax",
      "category": "cognitive",
      "url": "https://peptahub.com/peptides/n-acetyl-semax",
      "query": "\"N-Acetyl Semax\"[tiab] OR \"NA-Semax\"[tiab] OR \"Acetyl-Semax\"[tiab] OR \"Ac-MEHFPGP-NH2\"[tiab]",
      "query_terms": [
        "N-Acetyl Semax",
        "NA-Semax",
        "Acetyl-Semax",
        "Ac-MEHFPGP-NH2"
      ],
      "excluded_terms": [],
      "total_all_years": 0,
      "total_in_window": 0,
      "name_only_total": 0,
      "synonym_contribution": 0,
      "applied_context_total": 0,
      "applied_context_share": 0,
      "first_year_in_window": null,
      "publications_2016_2020": 0,
      "publications_2021_2025": 0,
      "growth_ratio_5y": null,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 0,
        "2021": 0,
        "2022": 0,
        "2023": 0,
        "2024": 0,
        "2025": 0,
        "2026": 0
      }
    },
    {
      "slug": "n-acetyl-semax-amidate",
      "name": "N-Acetyl Semax Amidate",
      "category": "cognitive",
      "url": "https://peptahub.com/peptides/n-acetyl-semax-amidate",
      "query": "\"N-Acetyl Semax Amidate\"[tiab] OR \"NA Semax Amidate\"[tiab] OR \"Ac-MEHFPGP-NH2\"[tiab] OR \"Acetylated Semax Amide\"[tiab]",
      "query_terms": [
        "N-Acetyl Semax Amidate",
        "NA Semax Amidate",
        "Ac-MEHFPGP-NH2",
        "Acetylated Semax Amide"
      ],
      "excluded_terms": [],
      "total_all_years": 0,
      "total_in_window": 0,
      "name_only_total": 0,
      "synonym_contribution": 0,
      "applied_context_total": 0,
      "applied_context_share": 0,
      "first_year_in_window": null,
      "publications_2016_2020": 0,
      "publications_2021_2025": 0,
      "growth_ratio_5y": null,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 0,
        "2021": 0,
        "2022": 0,
        "2023": 0,
        "2024": 0,
        "2025": 0,
        "2026": 0
      }
    },
    {
      "slug": "palmitoyl-oligopeptide",
      "name": "Palmitoyl Oligopeptide",
      "category": "skin",
      "url": "https://peptahub.com/peptides/palmitoyl-oligopeptide",
      "query": "\"Palmitoyl Oligopeptide\"[tiab] OR \"Palmitoyl Oligopeptide-3\"[tiab]",
      "query_terms": [
        "Palmitoyl Oligopeptide",
        "Palmitoyl Oligopeptide-3"
      ],
      "excluded_terms": [
        {
          "term": "Pal-Oligopeptide",
          "reason": "class-descriptor"
        },
        {
          "term": "Palm-Oligopeptide",
          "reason": "class-descriptor"
        }
      ],
      "total_all_years": 0,
      "total_in_window": 0,
      "name_only_total": 0,
      "synonym_contribution": 0,
      "applied_context_total": 0,
      "applied_context_share": 0,
      "first_year_in_window": null,
      "publications_2016_2020": 0,
      "publications_2021_2025": 0,
      "growth_ratio_5y": null,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 0,
        "2021": 0,
        "2022": 0,
        "2023": 0,
        "2024": 0,
        "2025": 0,
        "2026": 0
      }
    },
    {
      "slug": "snap-8",
      "name": "SNAP-8",
      "category": "skin",
      "url": "https://peptahub.com/peptides/snap-8",
      "query": "\"SNAP-8\"[tiab] OR \"Acetyl Octapeptide-3\"[tiab] OR \"Acetyl Glutamyl Heptapeptide-3\"[tiab] OR \"Octapeptide-2\"[tiab]",
      "query_terms": [
        "SNAP-8",
        "Acetyl Octapeptide-3",
        "Acetyl Glutamyl Heptapeptide-3",
        "Octapeptide-2"
      ],
      "excluded_terms": [],
      "total_all_years": 0,
      "total_in_window": 0,
      "name_only_total": 0,
      "synonym_contribution": 0,
      "applied_context_total": 0,
      "applied_context_share": 0,
      "first_year_in_window": null,
      "publications_2016_2020": 0,
      "publications_2021_2025": 0,
      "growth_ratio_5y": null,
      "reliability": "sparse",
      "reliability_note": "Fewer than 25 indexed records. Year-to-year movement at this scale is noise, not trend.",
      "by_year": {
        "2000": 0,
        "2001": 0,
        "2002": 0,
        "2003": 0,
        "2004": 0,
        "2005": 0,
        "2006": 0,
        "2007": 0,
        "2008": 0,
        "2009": 0,
        "2010": 0,
        "2011": 0,
        "2012": 0,
        "2013": 0,
        "2014": 0,
        "2015": 0,
        "2016": 0,
        "2017": 0,
        "2018": 0,
        "2019": 0,
        "2020": 0,
        "2021": 0,
        "2022": 0,
        "2023": 0,
        "2024": 0,
        "2025": 0,
        "2026": 0
      }
    }
  ]
}